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Colazal

Generic Name: balsalazide (bal SAL a zide)
Brand Name: Colazal, Giazo
Physician reviewed Colazal patient information - includes Colazal description, dosage and directions.
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Drug Information:
Colazal affects a substance in the body that causes inflammation, tissue damage, and diarrhea. The Colazal brand of balsalazide is used to treat mild to moderate active ulcerative colitis in adults and children who are at least 5 years old. The Giazo brand of balsalazide is used to treat mild to moderate active ulcerative colitis in men who are at least 18 years old. Colazal may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. Learn more

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Colazal Side Effects

Note: This document contains side effect information about balsalazide. Some of the dosage forms listed on this page may not apply to the brand name Colazal.

For the Consumer

Applies to balsalazide: oral capsule

Along with its needed effects, balsalazide (the active ingredient contained in Colazal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking balsalazide:

More common

  • Bloody diarrhea
  • fever
  • skin rash

Less common

  • Bladder pain
  • bloody or cloudy urine
  • bloody stools
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • heavy bleeding
  • lower back or side pain

Rare

  • Difficult or labored breathing
  • shortness of breath
  • tightness in the chest
  • wheezing

Incidence not known

  • Abdominal or stomach pain or tenderness
  • chills
  • clay colored stools
  • dark urine
  • decreased appetite
  • decreased frequency or amount of urine
  • dizziness
  • general feeling of tiredness or weakness
  • headache
  • increased blood pressure
  • increased thirst
  • itching
  • joint pain
  • light-colored stools
  • loss of appetite
  • nausea and vomiting
  • stomach pain, continuing
  • swelling of the face, fingers, feet, or lower legs
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood
  • weight gain
  • yellow eyes or skin

Some side effects of balsalazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • mild headache
  • muscle aches
  • sore throat
  • stuffy or runny nose

Less common

  • Acid or sour stomach
  • belching
  • bloated or full feeling
  • body aches or pain
  • bone pain
  • congestion
  • constipation
  • coughing
  • cramps
  • difficulty with moving
  • dry mouth
  • dryness of the throat
  • excess air or gas in the stomach or intestines
  • general feeling of discomfort or illness
  • heartburn
  • hoarseness
  • indigestion
  • muscle pain or stiffness
  • pale skin
  • passing of gas
  • shivering
  • sleeplessness
  • sneezing
  • stomach discomfort or upset
  • sweating
  • swelling or inflammation of the mouth
  • swollen joints
  • tender, swollen glands in the neck
  • trouble with sleeping
  • trouble with swallowing
  • troubled breathing with exertion
  • unable to sleep
  • unusual bleeding or bruising
  • voice changes
  • weight loss

Rare

  • Back pain
  • ear congestion
  • loss of appetite
  • loss of voice
  • pain in the ankles or knees
  • painful, red lumps under the skin, mostly on the legs
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Incidence not known

  • Hair loss or thinning of the hair

For Healthcare Professionals

Applies to balsalazide: oral capsule, oral tablet

Gastrointestinal

Very common (10% or more): Abdominal pain upper (17%), vomiting (17%), abdominal pain (12%), diarrhea (11%)

Common (1% to 10%): Flatulence, dyspepsia, dry mouth, constipation, colitis ulcerative, hematochezia, nausea, stomatitis

Frequency not reported: Defecation urgency, hard feces, gastroesophageal reflux disease, gastroenteritis

Postmarketing reports: Pancreatitis

Nervous system

Very common (10% or more): Headache (15%)

Frequency not reported: Dizziness, lethargy

Other

Very common (10% or more): Pyrexia (11%)

Common (1% to 10%): Fatigue, fever, flu-like disorder, pyrexia

Frequency not reported: Malaise, pain, pyrexia

Musculoskeletal

Common (1% to 10%): Arthralgia, musculoskeletal pain, myalgia, cramps

Frequency not reported: Back pain

Respiratory

Common (1% to 10%): Pharyngolaryngeal pain, coughing

Postmarketing reports: Alveolitis, pleural effusion

Hepatic

Frequency not reported: Increased aspartate aminotransferase

Postmarketing reports: Elevated liver enzymes (AST, ALT, GGT, LDH, alkaline phosphatase), elevated bilirubin, jaundice, cholestatic jaundice, cirrhosis, hepatocellular damage including liver necrosis and liver failure, Kawasaki-like syndrome including hepatic dysfunction

Hematologic

Common (1% to 10%): Anemia

Cardiovascular

Frequency not reported: Increased blood pressure, increased heart rate

Postmarketing reports: Myocarditis, pericarditis, vasculitis

Renal

Postmarketing reports: Renal failure, interstitial nephritis

Dermatologic

Frequency not reported: Erythema nodosum, rash, face edema

Postmarketing reports: Alopecia, pruritus

Immunologic

Common (1% to 10%): Nasopharyngitis, rhinitis, pharyngitis, urinary tract infection, influenza

Frequency not reported: Upper respiratory infection

Postmarketing reports: Pneumonia (with and without eosinophilia)

Metabolic

Common (1% to 10%): Anorexia

Psychiatric

Common (1% to 10%): Insomnia

Genitourinary

Common (1% to 10%): Dysmenorrhea

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Colazal (www.drugs.com/mtm/colazal.html).