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Clindesse

Generic Name: Clindamycin Vaginal Cream (One-Dose) (klin-da-MYE-sin)
Brand Names: Clindesse Cream
Clindesse (clindamycin) is used to treat vaginal infections caused by certain bacteria. Includes Clindesse side effects, interactions and indications.
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Drug Information:
Clindesse is a single-dose Therapy used to treat vaginal infections (bacterial vaginosis) caused by certain bacteria in non-pregnant women. Clindesse Cream is a topical lincomycin antibiotic. It works by slowing the growth of certain bacteria. The recommended dose is a single applicatorful at any time of the day. Clindesse may also be used for purposes other than those listed in this medication guide. Contact your doctor or health care prOvider right away if any of these apply to you. Some medical conditions may interact with Clindesse. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: Learn more

Clindesse Side Effects

Clindesse Side Effects

Note: This document contains side effect information about clindamycin topical. Some of the dosage forms listed on this page may not apply to the brand name Clindesse.

In Summary

Common side effects of Clindesse include: vulvovaginal candidiasis. Other side effects include: vaginal disease and vulvovaginitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to clindamycin topical: vaginal cream, vaginal suppository

Other dosage forms:

  • topical foam, topical gel/jelly, topical lotion, topical pad, topical solution

Along with its needed effects, clindamycin topical (the active ingredient contained in Clindesse) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking clindamycin topical:

More common

  • Itching of the vagina or genital area
  • pain during sexual intercourse
  • thick, white vaginal discharge with no odor or with mild odor

Less common

  • Diarrhea
  • dizziness
  • headache
  • nausea or vomiting
  • stomach pain or cramps

Rare

  • Burning, itching, rash, redness, swelling or other signs of skin problems not present before use of this medicine

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Itching of the vagina or genital area
  • pain during sexual intercourse
  • thick, white vaginal discharge with no odor or with mild odor

For Healthcare Professionals

Applies to clindamycin topical: topical foam, topical gel, topical kit, topical lotion, topical solution, topical swab, vaginal cream, vaginal suppository

Dermatologic

Lotion:

Very common (10% or more): Dryness (Up to 18%), erythema (Up to 14%), itching (Up to 11%), oiliness/oily skin (Up to 10%)

Common (1% to 10%): Seborrhea, skin problems, peeling, skin irritation, urticaria

Frequency not reported: Gram-negative folliculitis/folliculitis, contact dermatitis

Postmarketing reports: Rash, pruritus, blisters, papular pruritic skin rash, hair loss, skin inflammation, scaling, skin discoloration

Topical Gel:

Very common (10% or more): Dryness (Up to 23%), oiliness/oily skin (Up to 18%), itching (Up to 10%)

Common (1% to 10%): Erythema

Frequency not reported: Acne aggravated, erythema, scaly rash, skin disorder, gram-negative folliculitis, contact dermatitis

Topical Solution:

Very common (10% or more): Skin dryness (Up to 19%), erythema (Up to 16%), peeling (Up to 11%)

Common (1% to 10%): Skin oiliness/oily skin, skin problems, itching, irritation, urticaria

Frequency not reported: Gram-negative folliculitis, contact dermatitis

Vaginal Cream:

Frequency not reported: Rash, exanthema, urticaria, skin candida, pruritus (non-application site), rash macular, erythema, maculopapular rash

Genitourinary

Lotion:

Common (1% to 10%): Urinary tract infection

Postmarketing reports: Fertility disorders, bladder infection

Topical Solution:

Common (1% to 10%): Vaginitis

Vaginal Cream:

Very common (10% or more): Cervicitis/vaginitis (Up to 14%), vulvovaginal moniliasis/candidiasis (Up to 13.3%)

Common (1% to 10%): Vulvovaginal irritation/disorder/pain, vulvovaginitis trichomonal, Candida infection

Frequency not reported: Urinary tract/vaginal infection, menstrual disorder, metrorrhagia, vaginal discharge, endometriosis, proteinuria, dysuria

Postmarketing reports: Pelvic pain

Vaginal Suppository:

Common (1% to 10%): Vulvovaginal disorder, vaginal pain, vaginal moniliasis

Frequency not reported: Menstrual disorder, dysuria, vaginal discharge, vaginitis/vaginal infection

Vulvovaginal candidiasis, fungal infection, dysuria, and proteinuria occurred more frequently in pregnant patients given this drug compared to placebo for 7 days.

Local

Lotion:

Very common (10% or more): Application site burning/itching (Up to 11%)

Topical Gel:

Frequency not reported: Application site burning/dryness/erythema

Vaginal Cream:

Frequency not reported: Pruritus (topical application site)

Gastrointestinal

Lotion:

Common (1% to 10%): Diarrhea

Uncommon (0.1% to 1%): Vomiting

Frequency not reported: Abdominal pain, gastrointestinal disturbances

Postmarketing reports: Nausea, acute colitis, bloating, constipation, colored tongue, dyspepsia, flatulence, gastrointestinal distress/reflux, heartburn, pseudomembranous colitis, rectal bleeding

Topical Gel:

Frequency not reported: Abdominal pain, gastrointestinal disturbances, diarrhea, bloody diarrhea (including pseudomembranous colitis)

Topical Solution:

Common (1% to 10%): Diarrhea, vomiting, nausea, abdominal cramps/pain

Uncommon (0.1% to 1%): Gastrointestinal disturbances

Frequency not reported: Bloody diarrhea (including pseudomembranous colitis)

Vaginal Cream:

Frequency not reported: Heartburn, nausea, vomiting, diarrhea, constipation, localized/generalized abdominal pain, abdominal cramps, breath odor/halitosis, dyspepsia, flatulence, gastrointestinal disorder

Postmarketing reports: Pseudomembranous colitis, abdominal distension

Vaginal Suppository:

Frequency not reported: Abdominal cramps, localized/general abdominal pain

Nervous system

Lotion:

Very common (10% or more): Burning sensation (Up to 11%)

Postmarketing reports: Headache, dizziness, facial numbness, metallic taste, voice loss

Topical Gel:

Very common (10% or more): Burning sensation (up to 10%)

Topical Solution:

Very common (10% or more): Burning sensation (Up to 11%)

Vaginal Cream:

Frequency not reported: Dizziness, headache, vertigo, taste perversion

Other

Abnormal labor occurred in 1.1% of pregnant patients (in their second trimester) compared to 0% of patients given placebo for 7 days.

Fungal infections occurred in 1.7% of pregnant patients (in their second trimester) compared to 0% of patients given placebo for 7 days.

Lotion:

Common (1% to 10%): Dental procedure

Postmarketing reports: Facial swelling, fungal infection

Topical Gel:

Frequency not reported: Smarting

Topical Solution:

Common (1% to 10%): Dental procedure

Vaginal Cream:

Common (1% to 10%): Abnormal labor, fungal infection

Frequency not reported: Bacterial infection, inflammation, microbiology test abnormal, candida infection/moniliasis (body), inflammatory swelling

Postmarketing reports: Pain

Vaginal Suppository:

Common (1% to 10%): Fungal infection

Respiratory

Lotion:

Common (1% to 10%): Sore throat/tonsillitis/laryngitis

Uncommon (0.1% to 1%): Upper respiratory tract infection/cough/tracheitis

Postmarketing reports: Epistaxis

Topical Solution:

Common (1% to 10%): Sinusitis/congestion

Vaginal Cream:

Frequency not reported: Epistaxis, upper respiratory tract infection

Musculoskeletal

Lotion:

Uncommon (0.1% to 1%): Fracture

Topical Solution:

Common (1% to 10%): Fracture

Vaginal Cream:

Postmarketing reports: Back pain

Vaginal Suppository:

Frequency not reported: Flank pain

Immunologic

Lotion:

Common (1% to 10%): Cold/flu

Vaginal Cream:

Frequency not reported: Hypersensitivity

Ocular

Lotion:

Frequency not reported: Stinging of the eye, eye pain

Postmarketing reports: Eye irritation

Topical Gel:

Frequency not reported: Eye pain

Topical Solution:

Frequency not reported: Stinging of the eye, eye pain

Cardiovascular

Lotion:

Postmarketing reports: Edema, rapid heartbeat, chest tightness

Topical Solution:

Frequency not reported: Sensation of warmth

Renal

Vaginal Cream:

Frequency not reported: Glycosuria

Vaginal Suppository:

Frequency not reported: Pyelonephritis

Hypersensitivity

Lotion:

Postmarketing reports: Allergic reaction

Vaginal Cream:

Frequency not reported: Allergic reaction

Metabolic

Lotion:

Postmarketing reports: Weight loss

Vaginal Cream:

Frequency not reported: Hyperthyroidism

Hematologic

Lotion:

Postmarketing reports: Leukopenia

Hepatic

Topical Gel:

Postmarketing reports: Elevated liver enzymes

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Clindesse (www.drugs.com/clindesse.html).