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Note: This document contains side effect information about citric acid / magnesium oxide / sodium picosulfate. Some of the dosage forms listed on this page may not apply to the brand name Clenpiq.For the Consumer
Applies to citric acid/magnesium oxide/sodium picosulfate: oral powder for solution, oral solution
Along with its needed effects, citric acid / magnesium oxide / sodium picosulfate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking citric acid / magnesium oxide / sodium picosulfate:
Incidence not known
Some side effects of citric acid / magnesium oxide / sodium picosulfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
For Healthcare Professionals
Applies to citric acid / magnesium oxide / sodium picosulfate: oral powder for reconstitution, oral solutionGeneral
The most commonly reported side effects included headache, nausea, vomiting, and proctalgia.Renal
Very common (10% or more): Low glomerular filtration rate (up to 28.5%)
Common (1% to 10%): High creatinine
Low GFR occurred in 28.5% of patients using the day-before regimen compared to 25.1% of patients using the split-dose regimen at 24 to 48 hours after the colonoscopy.Cardiovascular
Orthostatic changes included changes in blood pressure and heart rate.
In a study, approximately 20% of pediatric patients 9 to 16 years of age given this drug had orthostatic changes for up to 5 days compared to 7% of patients given the comparator drug regimen (polyethylene glycol and electrolytes solution plus bisacodyl).
Very common (10% or more): Orthostatic changes (up to 20%)
Uncommon (0.1% to 1%): Orthostatic hypotension
Frequency not reported: Cardiac arrhythmiasMetabolic
Very common (10% or more): Hypermagnesemia (up to 11.6%)
Common (1% to 10%): Electrolyte abnormalities, hypochloremia, hypokalemia, hyponatremia, thirst
Uncommon (0.1% to 1%): Hypocalcemia
Frequency not reported: Abnormally low glucose levels (40 to 47 mg/dL), serious fluid and electrolyte abnormalities
Hypermagnesemia occurred in 11.6% of patients using the split-dose regimen compared to 8.7% of patients using the day-before regimen the day of the colonoscopy.
Abnormally low glucose levels were reported in asymptomatic pediatric patients, with one occurring at the colonoscopy, and one at the 5-day follow-up visit.
Hyponatremia has occurred with/without convulsions.Gastrointestinal
Common (1% to 10%): Abdominal distention, abdominal fullness, abdominal pain, anal discomfort, bloating, dry mouth, nausea, proctalgia, vomiting
Uncommon (0.1% to 1%): Abdominal cramps, anal irritation, aphthoid ileal ulcers/mild reversible aphthoid ileal ulcers, fecal incontinence
Frequency not reported: Abdominal bloating, colonic mucosal ulceration, diarrhea, flatulence, ischemic colitis, ulcerative colitis, watery diarrhea
Postmarketing reports: Severe diarrhea
Since abdominal bloating, distention, pain/cramping, and watery diarrhea were predicted to occur as part of the colon cleansing regimen, these side effects were included only if patients required medical attention or the condition significantly worsened during the study and was not in the frame of the usual clinical course.Nervous system
Generalized tonic-clonic seizures occurred with and without hyponatremia in patients with epilepsy.
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Convulsions, dizziness, epilepsy, grand mal convulsion
Frequency not reported: Generalized tonic-clonic seizures, seizuresPsychiatric
Common (1% to 10%): Sleep disorder
Uncommon (0.1% to 1%): Confusional stateOther
Common (1% to 10%): Fatigue
Frequency not reported: PainDermatologic
Uncommon (0.1% to 1%): Erythematous rash, maculopapular rash, purpura, rash, urticaria
Frequency not reported: PruritusHypersensitivity
Uncommon (0.1% to 1%): Anaphylactic reaction, hypersensitivity
Frequency not reported: Anaphylactoid reaction, anaphylaxisRespiratory
Frequency not reported: Aspiration
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