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Clenpiq is a combination medicine that causes diarrhea for the purpose of cleaning your colon before a colonoscopy. Cleaning the colon allows the inside of your colon to be seen more clearly on the colonoscopy.
Clenpiq is for use in adults and children at least 9 years old.
Clenpiq may also be used for purposes not listed in this medication guide.
This medicine can cause severe dehydration, which can lead to a serious electrolyte imbalance, seizures, kidney failure, or abnormal heartbeats that can cause death.
The risk of dehydration is highest in people with heart problems or kidney disease, or if you take certain other medicines. Tell your doctor about all your current medicines and any you start or stop using.
Call your doctor if you are sick with vomiting and cannot drink enough water for your bowel prep, or if you have a headache, dizziness, or decreased urination.
You should not use Clenpiq if you are allergic to citric acid, magnesium oxide, or sodium picosulfate, or if you have:
kidney disease;
a bowel obstruction, ileus, colitis or toxic megacolon;
a dilated intestine;
a perforation (a hole or tear) of your intestines; or
slow digestion.
Tell your doctor if you have ever had:
dehydration and an electrolyte imbalance (such as low levels of potassium, magnesium, or sodium in your blood);
a stomach or intestinal disorder, including ulcerative colitis;
gastroesophageal reflux disease (GERD);
kidney problems;
heart problems;
a seizure;
alcohol withdrawal; or
if you have recently used a sedative like Valium or Xanax (diazepam, alprazolam, lorazepam, and others).
Tell your doctor if you are pregnant or breastfeeding.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
It is especially important to follow all instructions about what to eat or drink in the days before your colon prep.
You must dilute the powder form of this medicine with 5 ounces of cold water before taking it.
The oral solution (liquid) may be taken without adding water.
Do not eat solid food once you start taking this medicine. Stop drinking all fluids at least 2 hours before the colonoscopy.
You will need to drink extra water once you start your colon prep. Drink only clear liquids and avoid alcohol, milk, or any drink that is red or purple.
This medicine can cause severe dehydration, which can lead to a serious electrolyte imbalance, seizures, kidney failure, or abnormal heartbeats that can cause death.
Call your doctor if you are sick with vomiting and cannot drink enough water for your bowel prep, or if you have a headache, dizziness, or decreased urination.
Store at room temperature, away from moisture and heat.
Call your doctor if you cannot drink the entire amount of medicine and liquids as instructed in time for your colonoscopy.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose can cause severe dehydration (severe headache or dizziness, vomiting, being unable to urinate). An overdose is unlikely to occur if you take Clenpiq exactly as directed.
Do not take other laxatives during your colon prep.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor right away if you have:
a light-headed feeling, like you might pass out;
confusion;
irregular heartbeats;
a seizure;
little or no urination;
severe nausea or vomiting;
painful bloating, severe stomach cramps;
rectal bleeding; or
trouble swallowing, trouble drinking liquids.
Common side effects may include:
stomach pain;
nausea, vomiting; or
headache.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Clenpiq can make it harder for your body to absorb other medicines you take by mouth within 1 hour before your colon prep.
If you take any of the following medicines, take them at least 2 hours before or not less than 6 hours after you take Clenpiq:
chlorpromazine;
digoxin;
iron;
penicillamine; o
certain antibiotics, such as ciprofloxacin, doxycycline, levofloxacin, minocycline, moxifloxacin, norfloxacin, or tetracycline.
Tell your doctor about all your other medicines, especially:
a laxative;
a diuretic or "water pill";
heart or blood pressure medication;
medicine to treat a kidney problem;
medicine to treat depression or mental illness;
seizure medication; or
NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may affect Clenpiq, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Further informationRemember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Clenpiq (www.drugs.com/mtm/clenpiq.html).
Note: This document contains side effect information about citric acid / magnesium oxide / sodium picosulfate. Some of the dosage forms listed on this page may not apply to the brand name Clenpiq.
For the ConsumerApplies to citric acid/magnesium oxide/sodium picosulfate: oral powder for solution, oral solution
Along with its needed effects, citric acid / magnesium oxide / sodium picosulfate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking citric acid / magnesium oxide / sodium picosulfate:
Incidence not known
Some side effects of citric acid / magnesium oxide / sodium picosulfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
For Healthcare Professionals
Applies to citric acid / magnesium oxide / sodium picosulfate: oral powder for reconstitution, oral solution
GeneralThe most commonly reported side effects included headache, nausea, vomiting, and proctalgia.
RenalVery common (10% or more): Low glomerular filtration rate (up to 28.5%)
Common (1% to 10%): High creatinine
Low GFR occurred in 28.5% of patients using the day-before regimen compared to 25.1% of patients using the split-dose regimen at 24 to 48 hours after the colonoscopy.
CardiovascularOrthostatic changes included changes in blood pressure and heart rate.
In a study, approximately 20% of pediatric patients 9 to 16 years of age given this drug had orthostatic changes for up to 5 days compared to 7% of patients given the comparator drug regimen (polyethylene glycol and electrolytes solution plus bisacodyl).
Very common (10% or more): Orthostatic changes (up to 20%)
Uncommon (0.1% to 1%): Orthostatic hypotension
Frequency not reported: Cardiac arrhythmias
MetabolicVery common (10% or more): Hypermagnesemia (up to 11.6%)
Common (1% to 10%): Electrolyte abnormalities, hypochloremia, hypokalemia, hyponatremia, thirst
Uncommon (0.1% to 1%): Hypocalcemia
Frequency not reported: Abnormally low glucose levels (40 to 47 mg/dL), serious fluid and electrolyte abnormalities
Hypermagnesemia occurred in 11.6% of patients using the split-dose regimen compared to 8.7% of patients using the day-before regimen the day of the colonoscopy.
Abnormally low glucose levels were reported in asymptomatic pediatric patients, with one occurring at the colonoscopy, and one at the 5-day follow-up visit.
Hyponatremia has occurred with/without convulsions.
GastrointestinalCommon (1% to 10%): Abdominal distention, abdominal fullness, abdominal pain, anal discomfort, bloating, dry mouth, nausea, proctalgia, vomiting
Uncommon (0.1% to 1%): Abdominal cramps, anal irritation, aphthoid ileal ulcers/mild reversible aphthoid ileal ulcers, fecal incontinence
Frequency not reported: Abdominal bloating, colonic mucosal ulceration, diarrhea, flatulence, ischemic colitis, ulcerative colitis, watery diarrhea
Postmarketing reports: Severe diarrhea
Since abdominal bloating, distention, pain/cramping, and watery diarrhea were predicted to occur as part of the colon cleansing regimen, these side effects were included only if patients required medical attention or the condition significantly worsened during the study and was not in the frame of the usual clinical course.
Nervous systemGeneralized tonic-clonic seizures occurred with and without hyponatremia in patients with epilepsy.
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Convulsions, dizziness, epilepsy, grand mal convulsion
Frequency not reported: Generalized tonic-clonic seizures, seizures
PsychiatricCommon (1% to 10%): Sleep disorder
Uncommon (0.1% to 1%): Confusional state
OtherCommon (1% to 10%): Fatigue
Frequency not reported: Pain
DermatologicUncommon (0.1% to 1%): Erythematous rash, maculopapular rash, purpura, rash, urticaria
Frequency not reported: Pruritus
HypersensitivityUncommon (0.1% to 1%): Anaphylactic reaction, hypersensitivity
Frequency not reported: Anaphylactoid reaction, anaphylaxis
RespiratoryFrequency not reported: Aspiration
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Clenpiq (www.drugs.com/mtm/clenpiq.html).
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March 31, 2021
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