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Cisplatin

Cisplatin Prescription
Generic Name: cisplatin (sis PLA tin)
Brand Name: Platinol, Platinol-AQ, Platinol (Restricted Access)
Physician reviewed cisplatin patient information - includes cisplatin description, dosage and directions.
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Cisplatin Drug Information:

Cisplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. Cisplatin is used together with other medications to treat bladder cancer, testicular cancer, or ovarian cancer. Cisplatin may also be used for purposes not listed in this medication guide. You should not receive cisplatin if you have kidney disease, bone marrow suppression, or hearing loss. Cisplatin can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before you receive cisplatin, tell your doctor about all other medications you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys. Call your doctor if you have little or no urinating, swelling or rapid weight gain, or shortness of breath. Learn more

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Cisplatin Side Effects

In Summary

Commonly reported side effects of cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cisplatin: intravenous powder for solution, intravenous solution

Warning

Intravenous route (Powder for Solution)

Administer under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. Cumulative renal toxicity associated with cisplatin is severe and other major dose-related toxicities include myelosuppression, nausea, and vomiting. Ototoxicity, which may be more pronounced in children, is significant. Anaphylactic-like reactions to cisplatin such as facial edema, bronchoconstriction, tachycardia, and hypotension have been reported and may occur within minutes of cisplatin administration. Exercise caution to prevent inadvertent cisplatin overdose as doses greater than 100 mg/m(2)/cycle once every 3 to 4 weeks are rarely used. Avoid inadvertent cisplatin overdose due to confusion with carboplatin or prescribing practices that fail to differentiate daily doses from total dose per cycle.

Side effects requiring immediate medical attention

Along with its needed effects, cisplatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way cancer medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Check with your doctor immediately if any of the following side effects occur while taking cisplatin:

Less common

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness accompanied by fever or chills
  • dizziness or faintness (during or shortly after a dose)
  • fast heartbeat (during or shortly after a dose)
  • fever or chills
  • lower back or side pain accompanied by fever or chills
  • painful or difficult urination accompanied by fever or chills
  • pain or redness at place of injection
  • pinpoint red spots on skin
  • swelling of face (during or shortly after a dose)
  • unusual bleeding or bruising
  • wheezing (during or shortly after a dose)

Check with your doctor as soon as possible if any of the following side effects occur while taking cisplatin:

More common

  • Joint pain
  • loss of balance
  • ringing in ears
  • swelling of feet or lower legs
  • trouble in hearing
  • unusual tiredness or weakness

Less common

  • Convulsions (seizures)
  • loss of reflexes
  • loss of taste
  • numbness or tingling in fingers or toes
  • trouble in walking

Rare

  • Agitation or confusion
  • blurred vision
  • change in ability to see colors (especially blue or yellow)
  • muscle cramps
  • sores in mouth and on lips

Side effects not requiring immediate medical attention

Some side effects of cisplatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Nausea and vomiting (severe)

Less common

  • Loss of appetite

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, Check with your doctor immediately if you notice the following side effects:

  • Black, tarry stools
  • blood in urine or stools
  • convulsions (seizures)
  • cough or hoarseness
  • decrease in urination
  • fever or chills
  • loss of balance
  • loss of reflexes
  • loss of taste
  • lower back or side pain
  • numbness or tingling in fingers or toes
  • painful or difficult urination
  • pinpoint red spots on skin
  • ringing in ears
  • swelling of feet or lower legs
  • trouble in hearing
  • trouble in walking
  • unusual bleeding or bruising

For Healthcare Professionals

Applies to cisplatin: compounding powder, intravenous powder for injection, intravenous solution

Renal

Very common (10% or more): Renal toxicity (36%)

Frequency not reported: Renal failure acute, renal tubular disorder

Gastrointestinal

Very common (10% or more): Nausea, vomiting, diarrhea

Rare (less than 0.1%): Stomatitis

Frequency not reported: Anorexia, hiccups

Nervous system

Rare (less than 0.1%): Convulsion, neuropathy peripheral, leukoencephalopathy, reversible posterior leukoencephalopathy syndrome

Frequency not reported: Cerebrovascular accident, hemorrhagic stroke, ischemic stroke ageusia, cerebral arteritis, Lhermitte's sign, myelopathy, autonomic neuropathy

Hematologic

Very common (10% or more): Leukopenia, thrombocytopenia, anemia

Frequency not reported: Coombs positive hemolytic anemia

Ocular

Frequency not reported: Vision blurred, color blindness acquired, blindness cortical, optic neuritis, papilledema, retinal pigmentation

Hypersensitivity

Uncommon (0.1% to 1%): Anaphylactoid reaction

Hepatic

Very rare (less than 0.01%): Hepatic enzymes increased, blood bilirubin increased

Local

Common (1% to 10%): Local soft tissue toxicity (e.g., cellulitis, fibrosis, necrosis, pain, edema, erythema) as the result of extravasation

Cardiovascular

Very rare (less than 0.01%): Cardiac arrest

Frequency not reported: Cardiac disorder, arrhythmia, bradycardia, tachycardia, thrombotic microangiopathy (hemolytic uremic syndrome), Raynaud's phenomenon

Endocrine

Uncommon (0.1% to 1%): Abnormal spermatogenesis

Frequency not reported: Blood amylase increased, inappropriate antidiuretic hormone secretion

Dermatologic

Frequency not reported: Rash, alopecia

Metabolic

Very common (10% or more): Anorexia, hyponatremia

Uncommon (0.1% to 1%): Hypomagnesemia

Frequency not reported: Dehydration, hypokalemia, hypophosphatemia, hyperuricemia, hypocalcemia, tetany

Immunologic

Common (1% to 10%): Sepsis

Frequency not reported: Infection

Musculoskeletal

Frequency not reported: Muscle spasms

Oncologic

Rare (less than 0.1%): Acute leukemia

Respiratory

Frequency not reported: Pulmonary embolism, wheezing

Other

Very common (10% or more): Tinnitus and/or high frequency hearing loss (31%), pyrexia

Frequency not reported: Tinnitus, deafness

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Cisplatin (www.drugs.com/mtm/cisplatin.html).