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Cinacalcet Hydrochloride

Cinacalcet hydrochloride Prescription
Generic Name: cinacalcet (sin ah CAL set)
Brand Name: Sensipar
Physician reviewed cinacalcet patient information - includes cinacalcet description, dosage and directions.
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Cinacalcet Hydrochloride Drug Information:

Cinacalcet decreases levels of paraThyroid hormone (PTH), calcium, and phosphorous in the body. Cinacalcet is used to treat hyperparaThyroidism (overactive functioning of the paraThyroid glands) in people who are on long-term dialysis for kidney disease. Cinacalcet is also used to treat hypercalcemia (high levels of calcium in the blood) in people with cancer of the paraThyroid gland, and in people with overactive paraThyroid glands that cannot be treated surgically. Cinacalcet may also be used for purposes not listed in this medication guide. Learn more

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Cinacalcet Hydrochloride Side Effects

In Summary

Commonly reported side effects of cinacalcet include: decreased plasma testosterone, diarrhea, dizziness, myalgia, nausea, vomiting, and hypoparathyroidism. Other side effects include: dialysis access infection, asthenia, chest pain, hypertension, hypotension, and anorexia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cinacalcet: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, cinacalcet may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cinacalcet:

More common

  • Blurred vision
  • chest pain
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat

Less common

  • Convulsions
  • cough or hoarseness
  • fever or chills
  • loss of bladder control
  • lower back or side pain
  • muscle spasm or jerking of all extremities
  • painful or difficult urination
  • sudden loss of consciousness

Incidence not known

  • Abdominal or stomach cramps
  • confusion
  • decreased urine output
  • difficulty with breathing
  • difficulty with moving
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fainting
  • irregular breathing
  • irregular heartbeats
  • joint pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • low bone turnover
  • mood or mental changes
  • muscle aching or cramping
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pains or stiffness
  • numbness and tingling around the mouth, fingertips, or feet
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • swollen joints
  • tightness in the chest
  • tremor
  • troubled breathing
  • unusual tiredness or weakness
  • weight gain
Side effects not requiring immediate medical attention

Some side effects of cinacalcet may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • lack or loss of strength
  • loss of appetite
  • nausea
  • vomiting
  • weight loss

Incidence not known

  • Hives or welts, itching, rash
  • redness of the skin

For Healthcare Professionals

Applies to cinacalcet: oral tablet


Very common (10% or more): Hypotension (11.6%)

Common (1% to 10%): Hypertension

Frequency not reported: Worsening heart failure, QT prolongation and ventricular arrhythmia secondary to hypocalcemia


Very common (10% or more): Nausea (31%), vomiting (27%), diarrhea (21%), dyspepsia (13%), abdominal pain (10.9%)

Common (1% to 10%): Upper abdominal pain, dyspepsia, anorexia, constipation


Common (1% to 10%): Hypersensitivity reactions

Postmarketing reports: Rash, angioedema, urticaria


Common (1% to 10%): Access site infection


Very common (10% or more): Paresthesia (14 to 29%)

Very rare (less than 0.01%): Leukocytoclastic vasculitis with palpable purpura on both upper and lower extremities


Common (1% to 10%): Anemia


Very common (10% or more): Hypocalcemia (11.2%)

Common (1% to 10%): Hyperkalemia, dehydration


Very common (10% or more): Cough (11.7%), upper respiratory infection (11%)

Common (1% to 10%): Dyspnea


Common (1% to 10%): Reduced testosterone levels


Very common (10% or more): Myalgia (15%), muscle spasms (11%)

Common (1% to 10%): Limb pain, back pain, fracture, arthralgia, noncardiac chest pain

Nervous system

Very common (10% or more): Paresthesia (up to 29%), headache (11.5%), dizziness (10%)

Common (1% to 10%): Fatigue, seizures


Common (1% to 10%): Asthenia


Common (1% to 10%): Dialysis access site infection

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Cinacalcet Hydrochloride (www.drugs.com/mtm/cinacalcet.html).