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Cilostazol

Generic Name: cilostazol (sye LOE sta zol)
Brand Name: Pletal
Physician reviewed cilostazol patient information - includes cilostazol description, dosage and directions.

Average Savings for cilostazol (generic): 48.09%
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Drug Information:
Cilostazol is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). Cilostazol dilates arteries that supply blood to your legs. Cilostazol also improves circulation by keeping platelets in the blood from sticking together and clotting. Cilostazol is used to treat the symptoms of intermittent Claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. Cilostazol improves your ability to walk longer distances without pain. Learn more

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Cilostazol Side Effects

In Summary

Commonly reported side effects of cilostazol include: infection, change in stool, diarrhea, dizziness, headache, palpitations, and pharyngitis. Other side effects include: abdominal pain, peripheral edema, rhinitis, and tachycardia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cilostazol: oral tablet

Warning

Oral route (Tablet)

Cilostazol is contraindicated in congestive heart failure of any severity. Cilostazol and many of its metabolites inhibit phosphodiesterase III. Several drugs with this pharmacologic effect have resulted in decreased survival compared with placebo in patients with class III to IV congestive heart failure.

Along with its needed effects, cilostazol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cilostazol:

More common

  • Fast or irregular heartbeat
  • fever

Less common

  • Abnormal bleeding
  • bloody or black tarry stools
  • bruises or red spots on the skin
  • fainting
  • nausea, heartburn, or indigestion (severe or continuing)
  • nosebleeds
  • stiff neck
  • stomach pain, cramping, or burning (severe)
  • swelling of the tongue
  • vomiting of blood or material that looks like coffee grounds

Incidence not known

  • Bleeding gums
  • bleeding tendency
  • blistering, peeling, loosening of the skin
  • blood in the urine or stools
  • blurred vision
  • chest pain
  • chills
  • clay-colored stools
  • confusion
  • cough or hoarseness
  • coughing up blood
  • dark urine
  • diarrhea
  • difficulty with breathing
  • drowsiness
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache, sudden and severe
  • inability to speak
  • itching of the eyes
  • itching of the skin
  • joint or muscle pain
  • light-colored stools
  • loss of appetite
  • loss of consciousness
  • lower back or side pain
  • nausea and vomiting
  • painful or difficult urination
  • pinpoint red spots on the skin
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seizures
  • skin rash
  • slurred speech
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach pain
  • swollen glands
  • temporary blindness
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness in the arm or leg on one side of the body, sudden and severe
  • weakness of part of the body
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking cilostazol:

Symptoms of overdose

  • Dizziness or lightheadedness when getting up suddenly from a lying or sitting position

Some side effects of cilostazol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • dizziness
  • gas
  • headache
  • increased cough
  • pain or stiffness in the muscles
  • pounding heartbeat
  • runny or stuffy nose
  • sore throat
  • swelling of the arms or legs

Less common

  • Bone pain
  • burning feeling in the throat or chest
  • difficulty with swallowing
  • hives
  • pain or stiffness in the joints
  • ringing or buzzing in the ears
  • swelling of the face, fingers, or lower legs

Incidence not known

  • Bruising
  • feeling of warmth
  • pain
  • redness of the face, neck, arms and occasionally, upper chest

For Healthcare Professionals

Applies to cilostazol: oral tablet

General

The most frequent adverse reactions resulting in discontinuation of therapy were headache, palpitation, and diarrhea.

Nervous system

Very common (10% or more): Headache (up to 34%), dizziness (up to 10%)

Frequency not reported: Tinnitus

Postmarketing reports: Intracranial hemorrhage, cerebral hemorrhage, cerebrovascular accident, extradural hematoma, subdural hematoma

Gastrointestinal

Very common (10% or more): Diarrhea (up to 19%), abnormal stools (up to 15%)

Common (1% to 10%): Dyspepsia, abdominal pain

Frequency not reported: Melena

Postmarketing reports: Gastrointestinal hemorrhage, vomiting, flatulence, nausea

Immunologic

Very common (10% or more): Infection (up to 14%)

Postmarketing reports: Anaphylaxis, angioedema, hypersensitivity

Respiratory

Very common (10% or more): Rhinitis (up to 12%), pharyngitis (up to 10%)

Frequency not reported: Epistaxis

Postmarketing reports: Pulmonary hemorrhage, interstitial pneumonia

Cardiovascular

Very common (10% or more): Palpitation (up to 10%)

Common (1% to 10%): Tachycardia

Frequency not reported: Atrial fibrillation, heart failure, myocardial infarction, nodal arrhythmia, supraventricular tachycardia, ventricular extrasystoles, ventricular tachycardia, left ventricular outflow obstruction

Postmarketing reports: Torsade de pointes, QTc prolongation, angina pectoris, hot flushes, blood pressure increased, subacute stent thrombosis, hypertension

Other

Common (1% to 10%): Peripheral edema

Frequency not reported: Fever, generalized edema, malaise

Postmarketing reports: Pain, chest pain

Metabolic

Frequency not reported: Anorexia, hyperuricemia

Postmarketing reports: Blood glucose increased, blood uric acid increased

Ocular

Frequency not reported: Conjunctivitis, retinal hemorrhage

Dermatologic

Frequency not reported: Urticaria

Postmarketing reports: Subcutaneous hemorrhage, pruritus, skin eruptions, Stevens-Johnson syndrome, skin drug eruption, rash

Hematologic

Frequency not reported: Anemia

Postmarketing reports: Aplastic anemia, granulocytopenia, pancytopenia, bleeding tendency

Genitourinary

Frequency not reported: Urinary frequency

Postmarketing reports: Hematuria

Renal

Frequency not reported: Creatinine increased

Postmarketing reports: BUN increased

Psychiatric

Frequency not reported: Insomnia

Hepatic

Postmarketing reports: Hepatic dysfunction, abnormal liver function tests, jaundice

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Cilostazol (www.drugs.com/mtm/cilostazol.html).