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Cilostazol is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). Cilostazol dilates arteries that supply blood to your legs. Cilostazol also improves circulation by keeping platelets in the blood from sticking together and clotting.
Cilostazol is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. Cilostazol improves your ability to walk longer distances without pain.
Cilostazol may also be used for purposes not listed in this medication guide.
Do not take cilostazol if you have congestive heart failure.
Do not take cilostazol if you have congestive heart failure. Cilostazol can make this condition worse.
To make sure cilostazol is safe for you, tell your doctor if you have:
liver or kidney disease;
heart disease; or
if you smoke.
It is not known whether cilostazol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether cilostazol passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Cilostazol is usually taken twice a day on an empty stomach, at least 30 minutes before or 2 hours after breakfast or dinner.
Take the medicine at the same time each day.
It may take up to 12 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.
Store at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Grapefruit and grapefruit juice may interact with cilostazol and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
chest pain, pounding heartbeats or fluttering in your chest;
a light-headed feeling, like you might pass out;
fever, chills, body aches, flu symptoms;
bloody urine, painful urination;
shortness of breath, even with mild exertion; or
swelling of your ankles or feet.
Common side effects may include:
headache, dizziness;
diarrhea, abnormal bowel movements;
upset stomach; or
runny nose.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Intermittent Claudication:
100 mg orally twice a day at least 30 minutes before or 2 hours after breakfast and dinner
Comments:
-Patients may respond as early as 2 to 4 weeks after initiation of therapy, but treatment for up to 12 weeks may be required before a beneficial effect is experienced.
-If symptoms remain unimproved after 3 months, discontinue this drug.
Use: Reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can interact with cilostazol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Cilostazol (www.drugs.com/mtm/cilostazol.html).
Commonly reported side effects of cilostazol include: infection, change in stool, diarrhea, dizziness, headache, palpitations, and pharyngitis. Other side effects include: abdominal pain, peripheral edema, rhinitis, and tachycardia. See below for a comprehensive list of adverse effects.
Applies to cilostazol: oral tablet
Oral route (Tablet)
Cilostazol is contraindicated in congestive heart failure of any severity. Cilostazol and many of its metabolites inhibit phosphodiesterase III. Several drugs with this pharmacologic effect have resulted in decreased survival compared with placebo in patients with class III to IV congestive heart failure.
Along with its needed effects, cilostazol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking cilostazol:
More common
Less common
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking cilostazol:
Symptoms of overdose
Some side effects of cilostazol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Incidence not known
Applies to cilostazol: oral tablet
The most frequent adverse reactions resulting in discontinuation of therapy were headache, palpitation, and diarrhea.
Very common (10% or more): Headache (up to 34%), dizziness (up to 10%)
Frequency not reported: Tinnitus
Postmarketing reports: Intracranial hemorrhage, cerebral hemorrhage, cerebrovascular accident, extradural hematoma, subdural hematoma
Very common (10% or more): Diarrhea (up to 19%), abnormal stools (up to 15%)
Common (1% to 10%): Dyspepsia, abdominal pain
Frequency not reported: Melena
Postmarketing reports: Gastrointestinal hemorrhage, vomiting, flatulence, nausea
Very common (10% or more): Infection (up to 14%)
Postmarketing reports: Anaphylaxis, angioedema, hypersensitivity
Very common (10% or more): Rhinitis (up to 12%), pharyngitis (up to 10%)
Frequency not reported: Epistaxis
Postmarketing reports: Pulmonary hemorrhage, interstitial pneumonia
Very common (10% or more): Palpitation (up to 10%)
Common (1% to 10%): Tachycardia
Frequency not reported: Atrial fibrillation, heart failure, myocardial infarction, nodal arrhythmia, supraventricular tachycardia, ventricular extrasystoles, ventricular tachycardia, left ventricular outflow obstruction
Postmarketing reports: Torsade de pointes, QTc prolongation, angina pectoris, hot flushes, blood pressure increased, subacute stent thrombosis, hypertension
Common (1% to 10%): Peripheral edema
Frequency not reported: Fever, generalized edema, malaise
Postmarketing reports: Pain, chest pain
Frequency not reported: Anorexia, hyperuricemia
Postmarketing reports: Blood glucose increased, blood uric acid increased
Frequency not reported: Conjunctivitis, retinal hemorrhage
Frequency not reported: Urticaria
Postmarketing reports: Subcutaneous hemorrhage, pruritus, skin eruptions, Stevens-Johnson syndrome, skin drug eruption, rash
Frequency not reported: Anemia
Postmarketing reports: Aplastic anemia, granulocytopenia, pancytopenia, bleeding tendency
Frequency not reported: Urinary frequency
Postmarketing reports: Hematuria
Frequency not reported: Creatinine increased
Postmarketing reports: BUN increased
Frequency not reported: Insomnia
Postmarketing reports: Hepatic dysfunction, abnormal liver function tests, jaundice
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Cilostazol (www.drugs.com/mtm/cilostazol.html).
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