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Ceftazidime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body.
Ceftazidime injection is used to treat many kinds of bacterial infections, including severe or life-threatening forms.
Ceftazidime may also be used for purposes not listed in this medication guide.
You should not use ceftazidime injection if you have ever had a severe allergic reaction to any cephalosporin antibiotic, or to a penicillin antibiotic.
You should not use this medicine if you have ever had a severe allergic reaction to ceftazidime or any other cephalosporin antibiotic, such as:
cefaclor (Raniclor);
cefadroxil (Duricef);
cefdinir (Omnicef);
cefazolin (Ancef);
cefditoren (Spectracef);
cefpodoxime (Vantin);
cefprozil (Cefzil);
ceftibuten (Cedax);
cefuroxime (Ceftin);
cephalexin (Keflex); or
cephradine (Velosef).
Before using ceftazidime, tell your doctor if you are allergic to any type of penicillin antibiotic, such as:
amoxicillin (Amoxil, Augmentin, Moxatag);
ampicillin (Principen, Unasyn);
dicloxacillin (Dycill, Dynapen);
oxacillin (Bactocill);
ticarcillin (Ticar, Timentin).
To make sure cefazolin is safe for you, tell your doctor if you have ever had:
kidney disease;
liver disease;
a stomach or intestinal disorder such as colitis;
seizures or epilepsy;
diabetes;
congestive heart failure; or
if you are malnourished.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Ceftazidime can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.
Ceftazidime can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Follow all directions on your prescription label. Do not use ceftazidime injection in larger or smaller amounts or for longer than recommended.
Ceftazidime is injected into a vein through an IV. You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.
You may need to mix ceftazidime with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.
Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ceftazidime will not treat a viral infection such as the flu or a common cold.
This medication can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using ceftazidime.
Store at room temperature away from moisture and heat.
If your medicine was provided in a frozen form or was frozen after mixing, thaw it in a refrigerator or at room temperature. Do not warm in a microwave or boiling water. Use the medicine as soon as possible after thawing it. Do not refreeze.
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
If you are receiving this medication at a clinic, call your doctor if you miss an appointment for your injection.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include muscle stiffness, restless feeling, confusion, uncontrolled movement of the hands, seizure, and coma.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe stomach pain, diarrhea that is watery or bloody; o
confusion, problems with speech or memory;
seizure (black-out or convulsions); or
a cold feeling, discoloration, or skin changes in your fingers.
Common side effects may include:
pain, swelling, burning, or irritation around the IV needle;
nausea, vomiting, diarrhea, stomach pain; or
vaginal itching or discharge.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Other drugs may interact with ceftazidime, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Further informationRemember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Ceftazidime (www.drugs.com/mtm/ceftazidime-injection.html).
Applies to ceftazidime: injection powder for solution
Along with its needed effects, ceftazidime may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking ceftazidime:
Less common
Rare
Incidence not known
Some side effects of ceftazidime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
For Healthcare Professionals
Applies to ceftazidime: injectable powder for injection, intravenous powder for injection, intravenous solution
HepaticCommon (1% to 10%): Transient elevations in 1 or more liver enzymes (alkaline dehydrogenase, ALT, AST, GGT)
Very rare (less than 0.01%): Jaundice
Postmarketing reports: Cholestasis, hyperbilirubinemia, liver dysfunction
LocalCommon (1% to 10%): Inflammation, pain, phlebitis, thrombophlebitis
Frequency not reported: Superficial desquamation around injection site
Inflammation and pain occurred after IM administration.
Phlebitis and thrombophlebitis occurred with IV administration.
HematologicApproximately 5% of patients developed a positive Coombs test.
Common (1% to 10%): Eosinophilia, positive Coombs test, thrombocytosis
Uncommon (0.1% to 1%): Leukopenia, neutropenia, thrombocytopenia
Frequency not reported: Agranulocytosis, hemolytic anemia, lymphocytosis, positive Coombs test without hemolysis
Postmarketing reports: Aplastic anemia, pancytopenia, prothrombin time prolonged
DermatologicCommon (1% to 10%): Maculopapular rash, rash, urticarial rash
Uncommon (0.1% to 1%): Pruritus
Very rare (less than 0.01%): Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis
Frequency not reported: Drug reaction with eosinophilia and systemic symptoms (DRESS)
Postmarketing reports: Urticaria
GastrointestinalPseudomembranous colitis may have been presented as diarrhea or colitis.
Common (1% to 10%): Diarrhea
Uncommon (0.1% to 1%): Abdominal pain, antibacterial agent-associated colitis/diarrhea, colitis, nausea, vomiting
Frequency not reported: Pseudomembranous colitis
MetabolicCommon (1% to 10%): Transient elevations in LDH
Postmarketing reports: False-positive test for urinary glucose
RenalUncommon (0.1% to 1%): Transient elevations of blood urea/blood urea nitrogen (BUN)/serum creatinine
Very rare (less than 0.01%): Acute renal failure, interstitial nephritis
Postmarketing reports: Renal dysfunction, toxic nephropathy
Nervous systemNeurological sequelae occurred in patients with renal dysfunction who did not receive appropriate dose adjustments and included coma, convulsions, encephalopathy, myoclonia, and tremor.
Uncommon (0.1% to 1%): Dizziness, headache
Very rare (less than 0.01%): Bad taste, paresthesia,
Frequency not reported: Asterixis, coma, convulsions, encephalopathy, myoclonia, neurological sequelae, neuromuscular excitability, seizures, tremor
ImmunologicUncommon (0.1% to 1%): Candidiasis, oral thrush
GenitourinaryUncommon (0.1% to 1%): Vaginitis
OtherUncommon (0.1% to 1%): Fever
HypersensitivityVery rare (less than 0.01%): Anaphylaxis, angioedema
Postmarketing reports: Allergic reactions
Anaphylaxis included bronchospasm, cardiopulmonary arrest, and/or hypotension.
CardiovascularVery rare (less than 0.01%): Hypotension
Frequency not reported: Hot flushes
Postmarketing reports: Cardiopulmonary arrest, hemorrhage
RespiratoryVery rare (less than 0.01%): Bronchospasm
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Ceftazidime (www.drugs.com/mtm/ceftazidime-injection.html).
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