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Cefprozil Prescription
Generic Name: Cefprozil Tablets (sef PROE zil)
Easy-to-read patient leaflet for Cefprozil Tablets. Includes indications, proper use, special instructions, precautions, and possible side effects.

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Cefprozil Drug Information:

This medicine may interact with other drugs or health problems. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (cefprozil tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use this medicine (cefprozil tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

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Cefprozil Side Effects

In Summary

More frequently reported side effects include: oral candidiasis, vulvovaginal candidiasis, abdominal pain, diarrhea, nausea, vaginitis, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cefprozil: oral powder for suspension, oral tablet

Along with its needed effects, cefprozil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cefprozil:

Less common

  • Black, tarry stools
  • chest pain
  • cough or hoarseness
  • diarrhea
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • shortness of breath
  • sore throat sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness


  • Abdominal or stomach cramps, pain, or tenderness
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloating
  • blood in the urine or stools
  • clay-colored stools
  • dark urine
  • diarrhea, watery and severe, which may also be bloody
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • feeling of discomfort
  • headache
  • hives
  • increased thirst
  • inflammation of the joints
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • muscle aches
  • nausea or vomiting
  • pain
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • shortness of breath
  • swollen lymph glands
  • tightness in the chest
  • unpleasant breath odor
  • unusual weight loss
  • vomiting of blood
  • watery or bloody diarrhea
  • wheezing
  • yellow eyes or skin

Incidence not known

  • Back, leg, or stomach pains
  • bleeding gums
  • bloody or cloudy urine
  • bloody, black, or tarry stools
  • decrease in urine output or decrease in urine-concentrating ability
  • difficulty with breathing
  • fever with or without chills
  • general body swelling
  • general feeling of tiredness or weakness
  • high fever
  • nosebleeds
  • pale skin
  • sudden decrease in the amount of urine
  • swollen or painful glands

Some side effects of cefprozil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Itching or pain of the vagina or genital area
  • pain during sexual intercourse
  • thick, white vaginal discharge with no odor or with a mild odor


  • Confusion
  • hives or welts
  • nervousness
  • redness of the skin
  • restlessness
  • sleepiness or unusual drowsiness
  • sleeplessness
  • trouble sitting still
  • trouble with sleeping
  • unable to sleep

For Healthcare Professionals

Applies to cefprozil: oral powder for reconstitution, oral tablet


Cefprozil is generally well-tolerated.


Up to 20% of patients with penicillin allergy may demonstrate allergy to cefprozil.

Hypersensitivity reactions have included rash (0.9%), urticaria (0.1%), anaphylaxis, angioedema, bronchospasm, eosinophilia, erythema multiforme, fever, serum-sickness-like reactions, and Stevens-Johnson syndrome.


Pseudomembranous colitis has been reported in patients treated with cephalosporin antibiotics. If diarrhea occurs and is unresponsive to discontinuation of the drug and/or standard therapy, pseudomembranous colitis should be considered.

Gastrointestinal side effects have included nausea (3.5%), diarrhea (2.9%), vomiting (1%), and abdominal pain (1%). Rare cases of Clostridium difficile colitis have been reported with some cephalosporins.


Hematologic side effects have included eosinophilia (2.3%), decreased leukocyte count (0.2%), and thrombocytopenia. Cephalosporins as a class have been associated with aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs' test, pancytopenia, neutropenia, and agranulocytosis.


Renal side effects have included elevated serum creatinine (0.1%) and BUN (0.1%). Some other cephalosporins have included interstitial nephritis. (Reversible fever, azotemia, pyuria, and eosinophiluria are the hallmarks of cephalosporin-induced interstitial nephritis.) Cephalosporins as a class have been associated with toxic nephropathy and renal dysfunction.


Genitourinary side effects have included vaginitis and genital pruritus in 1.6% of patients.


Hepatic side effects have included increased AST (2%), ALT (2%), alkaline phosphatase (0.2%), and bilirubin ([Ref]

Nervous system

Nervous system side effects have included dizziness in 1% of patients, and hyperactivity, headache, nervousness, insomnia, confusion, and somnolence in [Ref]


Other side effects have included superinfection and diaper rash in 1.5% of patients.


Dermatologic side effects have included rash (0.9%), urticaria (0.1%), and erythema multiforme. Cefprozil has been associated with rash in a patients with infectious mononucleosis.

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Cefprozil (www.drugs.com/cefprozil.html).