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More frequently reported side effects include: oral candidiasis, vulvovaginal candidiasis, abdominal pain, diarrhea, nausea, vaginitis, and vomiting. See below for a comprehensive list of adverse effects.For the Consumer
Applies to cefprozil: oral powder for suspension, oral tablet
Along with its needed effects, cefprozil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking cefprozil:
Incidence not known
Some side effects of cefprozil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For Healthcare Professionals
Applies to cefprozil: oral powder for reconstitution, oral tabletGeneral
Cefprozil is generally well-tolerated.Hypersensitivity
Up to 20% of patients with penicillin allergy may demonstrate allergy to cefprozil.
Hypersensitivity reactions have included rash (0.9%), urticaria (0.1%), anaphylaxis, angioedema, bronchospasm, eosinophilia, erythema multiforme, fever, serum-sickness-like reactions, and Stevens-Johnson syndrome.Gastrointestinal
Pseudomembranous colitis has been reported in patients treated with cephalosporin antibiotics. If diarrhea occurs and is unresponsive to discontinuation of the drug and/or standard therapy, pseudomembranous colitis should be considered.
Gastrointestinal side effects have included nausea (3.5%), diarrhea (2.9%), vomiting (1%), and abdominal pain (1%). Rare cases of Clostridium difficile colitis have been reported with some cephalosporins.Hematologic
Hematologic side effects have included eosinophilia (2.3%), decreased leukocyte count (0.2%), and thrombocytopenia. Cephalosporins as a class have been associated with aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs' test, pancytopenia, neutropenia, and agranulocytosis.Renal
Renal side effects have included elevated serum creatinine (0.1%) and BUN (0.1%). Some other cephalosporins have included interstitial nephritis. (Reversible fever, azotemia, pyuria, and eosinophiluria are the hallmarks of cephalosporin-induced interstitial nephritis.) Cephalosporins as a class have been associated with toxic nephropathy and renal dysfunction.Genitourinary
Genitourinary side effects have included vaginitis and genital pruritus in 1.6% of patients.Hepatic
Hepatic side effects have included increased AST (2%), ALT (2%), alkaline phosphatase (0.2%), and bilirubin ([Ref]Nervous system
Nervous system side effects have included dizziness in 1% of patients, and hyperactivity, headache, nervousness, insomnia, confusion, and somnolence in [Ref]Other
Other side effects have included superinfection and diaper rash in 1.5% of patients.Dermatologic
Dermatologic side effects have included rash (0.9%), urticaria (0.1%), and erythema multiforme. Cefprozil has been associated with rash in a patients with infectious mononucleosis.
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