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Cefixime Prescription
Generic Name: cefixime (sef IX eem)
Brand Name: Suprax
Physician reviewed cefixime patient information - includes cefixime description, dosage and directions.
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Cefixime Drug Information:

Cefixime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. Cefixime is used to treat many different types of infections caused by bacteria. Cefixime may also be used for purposes not listed in this medication guide. You should not take cefixime if you are allergic to cefixime, or to similar antibiotics, such as Ceftin, Cefzil, Keflex, Omnicef, and others. Tell your doctor if you are allergic to penicillins. You should not take this medicine if you are allergic to cefixime or to other cephalosporin antibiotics, such as: Learn more

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Cefixime Side Effects

For the Consumer

Applies to cefixime: oral capsule, oral powder for suspension, oral tablet, oral tablet chewable

Along with its needed effects, cefixime may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cefixime:

More common

  • Diarrhea
  • loose or frequent stools

Less common

  • Abdominal or stomach pain
  • agitation
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • blood in the urine or stools
  • chest pain
  • chills
  • clay-colored stools
  • coma
  • confusion
  • cough
  • dark urine
  • decreased urine output
  • depression
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • feeling of discomfort
  • fever
  • general tiredness and weakness
  • headache
  • hives, itching, or skin rash
  • hostility
  • inflammation of the joints
  • irritability
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lethargy
  • light-colored stools
  • loss of appetite
  • lower back or side pain
  • muscle aches
  • muscle twitching
  • nausea and vomiting
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seizures
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stupor
  • swelling of the face, ankles, or hands
  • swollen glands
  • swollen lymph glands
  • tightness in the chest
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • vomiting of blood
  • yellow eyes or skin

Incidence not known

  • Abdominal or stomach cramps or tenderness
  • back, leg, or stomach pains
  • cough or hoarseness
  • coughing up blood
  • diarrhea, watery and severe, which may also be bloody
  • general body swelling
  • increased menstrual flow or vaginal bleeding
  • increased thirst
  • nosebleeds
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • sudden decrease in the amount of urine
  • unpleasant breath odor
  • unusual weight loss

Some side effects of cefixime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Acid or sour stomach
  • belching
  • bloated
  • excess air or gas in the stomach or intestines
  • full feeling
  • heartburn
  • hives or welts
  • indigestion
  • itching of the vagina or genital area itching or pain of the genital area
  • pain during sexual intercourse
  • passing gas
  • redness of the skin
  • stomach discomfort, upset, or pain
  • thick, white vaginal discharge with no odor or with a mild odor
  • white patches in the mouth or throat or on the tongue
  • white patches with diaper rash

For Healthcare Professionals

Applies to cefixime: oral capsule, oral powder for reconstitution, oral tablet, oral tablet chewable


The most commonly reported side effects included gastrointestinal effects, diarrhea, nausea, and/or frequent/loose stools.


Very common (10% or more): Gastrointestinal effects (up to 30%), diarrhea (up to 16%)

Common (1% to 10%): abdominal pain, dyspepsia, flatulence, frequent stools, loose stools, nausea

Uncommon (0.1% to 1%): Vomiting

Very rare (less than 0.01%): Antibiotic-associated colitis

Frequency not reported: Marked diarrhea, moderate diarrhea, severe diarrhea, pseudomembranous colitis

Postmarketing reports: Colitis

Diarrhea more commonly occurred with higher doses. Treatment cessation was occasionally warranted in patients who developed moderate to severe diarrhea. Patients who develop marked diarrhea should discontinue treatment.


Uncommon (0.1% to 1%): Alkaline phosphatase increased, ALT increased, AST increased, liver enzyme increased

Very rare (less than 0.01%): Cholestatic jaundice, hepatitis

Frequency not reported: Blood bilirubin increased, jaundice

Postmarketing reports: Cholestasis, hyperbilirubinemia, liver dysfunction


Uncommon (0.1% to 1%): Rash/skin rash

Rare (0.01% to 0.1%): Pruritus

Very rare (less than 0.01%): Drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome, toxic epidermal necrolysis

Frequency not reported: Erythema multiforme, face edema, urticaria

Nervous system

Encephalopathy included confusion, convulsions, impaired consciousness, and/or movement disorders; beta-lactams predispose patients to the risk of this side effect, especially in cases of overdose or renal dysfunction.

Convulsions occurred with cephalosporins.

Uncommon (0.1% to 1%): Headache

Rare (0.01% to 0.1%): Vertigo

Very rare (less than 0.01%): Psychomotor hyperactivity

Frequency not reported: Convulsions, consciousness impaired, dizziness, encephalopathy, movement disorders

Postmarketing reports: Seizures


Rare (0.01% to 0.1%): Bacterial superinfection, fungal superinfection

Very rare (less than 0.01%): Serum sickness-like reaction/serum sickness

Postmarketing reports: Candidiasis, superinfection


Rare (0.01% to 0.1%): Angioneurotic edema, hypersensitivity

Very rare (less than 0.01%): Anaphylactic shock

Frequency not reported: Anaphylactic reaction/anaphylactoid reaction, angioedema

Postmarketing reports: Allergic reactions, anaphylactic shock, fatal anaphylactic reaction


Rare (0.01% to 0.1%): Mucosal inflammation, pyrexia

Very rare (less than 0.01%): Drug fever


Rare (0.01% to 0.1%): Eosinophilia

Very rare (less than 0.01%): Agranulocytosis, hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia

Frequency not reported: Direct positive Coombs test, granulocytopenia, hypereosinophilia, indirect positive Coombs test, neutropenia, thrombocytosis

Postmarketing reports: Aplastic anemia, prothrombin time prolongation


Rare (0.01% to 0.1%): Blood urea increased

Very rare (less than 0.01%): Acute renal failure, blood creatinine increased, interstitial nephritis, tubulointerstitial nephritis

Postmarketing reports: Renal dysfunction, toxic nephropathy, transient blood urea nitrogen elevation (BUN)

Tubulointerstitial nephritis was an underlying pathological condition of acute renal failure.


Rare (0.01% to 0.1%): Anorexia


Frequency not reported: Dyspnea


Frequency not reported: Arthralgia


Frequency not reported: Genital pruritus, vaginitis


Postmarketing reports: Hemorrhage


Postmarketing reports: Elevated lactate dehydrogenase (LDH)


Frequency not reported: Confusion

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Cefixime (www.drugs.com/mtm/cefixime.html).