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Applies to cefepime: injection powder for solution
Along with its needed effects, cefepime may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking cefepime:
Incidence not known
Some side effects of cefepime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For Healthcare Professionals
Applies to cefepime: injectable powder for injection, intravenous powder for injection, intravenous solutionGeneral
The most commonly reported side effects included positive Coombs' Test (without hemolysis), localized reactions, increased ALT, and diarrhea.Hematologic
Agranulocytosis, aplastic anemia, hemolytic anemia, neutropenia, pancytopenia, thrombocytopenia, and transient leukopenia were reported with cephalosporin use.
Very common (10% or more): Positive Coombs' Test without hemolysis (up to 18.7%)
Common (1% to 10%): Abnormal partial thromboplastin time (PTT), abnormal prothrombin time (PT), anemia, eosinophilia, PT prolonged, PTT prolonged
Uncommon (0.1% to 1%): Decreased hematocrit, decreased neutrophils/neutropenia, decreased platelets/thrombocytopenia/transient thrombocytopenia, decreased white blood cell counts/leukopenia/transient leukopenia
Rare (0.01% to 0.1%): Transient neutropenia
Frequency not reported: Agranulocytosis, aplastic anemia, hemolytic anemia
Postmarketing reports: PancytopeniaHepatic
Common (1% to 10%): Alkaline phosphatase increased, blood bilirubin increased, increased ALT, increased AST, increased total bilirubin
Postmarketing reports: Cholestasis, liver dysfunction
Liver dysfunction and cholestasis were reported with cephalosporin use.Local
Common (1% to 10%): Infusion site reactions/local reactions, injection site inflammation, injection site pain
Uncommon (0.1% to 1%): Infusion site inflammation
Local reactions included inflammation, pain, phlebitis, and rash, and occurred irrespective to this drug in patients who received IV infusion.Gastrointestinal
Higher doses (2 grams every 8 hours) have been associated with a higher incidence of side effects, including diarrhea, nausea, and vomiting.
Common (1% to 10%): Diarrhea, nausea, vomiting
Uncommon (0.1% to 1%): Colitis, oral candidiasis, oral moniliasis, pseudomembranous colitis
Rare (0.01% to 0.1%): Abdominal pain, constipation
Frequency not reported: Clostridium difficile-associated diarrhea, gastrointestinal disorderDermatologic
Common (1% to 10%): Pruritus, rash/skin rash
Uncommon (0.1% to 1%): Erythema, urticaria
Frequency not reported: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis
Higher doses (2 grams every 8 hours) have been associated with a higher incidence of side effects, including rash and pruritus.
The most frequently reported side effect in pediatric patient was rash.
Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis were reported with cephalosporin use.Other
Common (1% to 10%): Fever/pyrexia
Uncommon (0.1% to 1%): Inflammation, pain
Rare (0.01% to 0.1%): Chills
Higher doses (2 grams every 8 hours) have been associated with a higher incidence of side effects, including fever.Cardiovascular
Hemorrhage was reported with cephalosporin use.
Common (1% to 10%): Phlebitis/infusion site phlebitis
Rare (0.01% to 0.1%): Vasodilation
Frequency not reported: HemorrhageMetabolic
Hypocalcemia occurred more frequently in older patients.
False positive glycosuria was reported with cephalosporin use.
Common (1% to 10%): Decreased phosphorus
Uncommon (0.1% to 1%): Decreased calcium, hypocalcemia, increased calcium, increased phosphorus, increased potassium
Frequency not reported: False positive glycosuriaNervous system
Higher doses (2 grams every 8 hours) have been associated with a higher incidence of side effects, including headache.
Encephalopathy included coma, confusion, consciousness disorder, hallucinations, and stupor.
Coma, consciousness disorder, convulsions, encephalopathy, myoclonus, and stupor were reported with cephalosporin use.
Common (1% to 10%): Headache
Rare (0.01% to 0.1%): Convulsions, dizziness, dysgeusia, paresthesia, taste perversion
Very rare (less than 0.01%): Seizures
Frequency not reported: Altered state of consciousness/consciousness disorder, coma, encephalopathy, myoclonus, neurotoxicity, stupor
Postmarketing reports: Aphasia, nonconvulsive status epilepticusRespiratory
Rare (0.01% to 0.1%): DyspneaRenal
Renal failure and toxic nephropathy were reported with cephalosporin use.
Uncommon (0.1% to 1%): Blood creatinine increased/increased creatinine, blood urea increased/increased blood urea nitrogen (BUN), transient increase in serum creatinine, transient increase in serum urea, transient uremia
Frequency not reported: Renal dysfunction, renal failure, toxic nephropathyGenitourinary
Uncommon (0.1% to 1%): Vaginal infection, vaginitis
Rare (0.01% to 0.1%): Genital pruritusHypersensitivity
Rare (0.01% to 0.1%): Anaphylactic reaction, angioedema
Frequency not reported: Anaphylactic shock, anaphylaxis, hypersensitivity reactions
Anaphylactic shock and anaphylaxis were reported with cephalosporin use.Immunologic
Rare (0.01% to 0.1%): Candidiasis, unspecified moniliasisPsychiatric
Confusion and hallucinations were reported with cephalosporin use.
Frequency not reported: Confusion/state of confusion, hallucinations
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