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Cefepime

Generic Name: cefepime (injection) (SEF e peem)
Brand Name: Maxipime, Maxipime ADD-Vantage
Physician reviewed cefepime (injection) (injection) patient information - includes cefepime (injection) description, dosage and directions.
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Drug Information:
Cefepime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. Cefepime injection is used to treat many kinds of bacterial infections, including severe or life-threatening forms. Cefepime may also be used for purposes not listed in this medication guide. You should not use cefepime if you are allergic to certain antibiotics, including cefepime and similar medicines (Keflex, Omnicef, and others), or penicillin antibiotics (Amoxicillin, Ampicillin, piperacillin, ticarcillin, Augmentin, and others). Learn more

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Cefepime Side Effects

For the Consumer

Applies to cefepime: injection powder for solution

Along with its needed effects, cefepime may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cefepime:

More common

  • Abdominal or stomach cramps
  • back, leg, or stomach pains
  • bleeding gums, nosebleeds
  • confusion
  • convulsions
  • dark urine
  • difficulty with breathing
  • fever, chills
  • general body swelling
  • headache
  • irregular heartbeats
  • loss of appetite
  • mood or mental changes
  • muscle cramps in the hands, arms, feet, legs, or face
  • nausea or vomiting
  • numbness and tingling around the mouth, fingertips, or feet
  • tremor
  • yellowing of the eyes or skin

Less common

  • Bluish color
  • pain, tenderness
  • swelling of the foot or leg

Rare

  • Diarrhea
  • inflammation or swelling
  • watery or bloody diarrhea

Incidence not known

  • Agitation
  • blistering, peeling, or loosening of the skin
  • bloody or cloudy urine
  • bloody, black, or tarry stools
  • blurred vision
  • change in consciousness
  • chest pain
  • cough or hoarseness
  • difficult or painful urination
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • general feeling of tiredness or weakness
  • itching, hives
  • muscle twitching or jerking
  • paralysis
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • rhythmic movement of the muscles
  • seeing, hearing, or feeling things that are not there
  • seizures
  • severe sleepiness
  • stiff neck
  • sudden decrease in the amount of urine
  • swollen or painful glands
  • unpleasant breath odor
  • unusual bleeding or bruising
  • vomiting of blood

Some side effects of cefepime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Red streaks on the skin
  • swelling, tenderness, or pain at the injection site

Rare

  • Itching of the vagina or genital area
  • pain during sexual intercourse
  • redness of the skin
  • sore mouth or tongue
  • thick, white vaginal discharge with no odor or with a mild odor
  • white patches in the mouth, tongue, or throat

For Healthcare Professionals

Applies to cefepime: injectable powder for injection, intravenous powder for injection, intravenous solution

General

The most commonly reported side effects included positive Coombs' Test (without hemolysis), localized reactions, increased ALT, and diarrhea.

Hematologic

Agranulocytosis, aplastic anemia, hemolytic anemia, neutropenia, pancytopenia, thrombocytopenia, and transient leukopenia were reported with cephalosporin use.

Very common (10% or more): Positive Coombs' Test without hemolysis (up to 18.7%)

Common (1% to 10%): Abnormal partial thromboplastin time (PTT), abnormal prothrombin time (PT), anemia, eosinophilia, PT prolonged, PTT prolonged

Uncommon (0.1% to 1%): Decreased hematocrit, decreased neutrophils/neutropenia, decreased platelets/thrombocytopenia/transient thrombocytopenia, decreased white blood cell counts/leukopenia/transient leukopenia

Rare (0.01% to 0.1%): Transient neutropenia

Frequency not reported: Agranulocytosis, aplastic anemia, hemolytic anemia

Postmarketing reports: Pancytopenia

Hepatic

Common (1% to 10%): Alkaline phosphatase increased, blood bilirubin increased, increased ALT, increased AST, increased total bilirubin

Postmarketing reports: Cholestasis, liver dysfunction

Liver dysfunction and cholestasis were reported with cephalosporin use.

Local

Common (1% to 10%): Infusion site reactions/local reactions, injection site inflammation, injection site pain

Uncommon (0.1% to 1%): Infusion site inflammation

Local reactions included inflammation, pain, phlebitis, and rash, and occurred irrespective to this drug in patients who received IV infusion.

Gastrointestinal

Higher doses (2 grams every 8 hours) have been associated with a higher incidence of side effects, including diarrhea, nausea, and vomiting.

Common (1% to 10%): Diarrhea, nausea, vomiting

Uncommon (0.1% to 1%): Colitis, oral candidiasis, oral moniliasis, pseudomembranous colitis

Rare (0.01% to 0.1%): Abdominal pain, constipation

Frequency not reported: Clostridium difficile-associated diarrhea, gastrointestinal disorder

Dermatologic

Common (1% to 10%): Pruritus, rash/skin rash

Uncommon (0.1% to 1%): Erythema, urticaria

Frequency not reported: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis

Higher doses (2 grams every 8 hours) have been associated with a higher incidence of side effects, including rash and pruritus.

The most frequently reported side effect in pediatric patient was rash.

Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis were reported with cephalosporin use.

Other

Common (1% to 10%): Fever/pyrexia

Uncommon (0.1% to 1%): Inflammation, pain

Rare (0.01% to 0.1%): Chills

Higher doses (2 grams every 8 hours) have been associated with a higher incidence of side effects, including fever.

Cardiovascular

Hemorrhage was reported with cephalosporin use.

Common (1% to 10%): Phlebitis/infusion site phlebitis

Rare (0.01% to 0.1%): Vasodilation

Frequency not reported: Hemorrhage

Metabolic

Hypocalcemia occurred more frequently in older patients.

False positive glycosuria was reported with cephalosporin use.

Common (1% to 10%): Decreased phosphorus

Uncommon (0.1% to 1%): Decreased calcium, hypocalcemia, increased calcium, increased phosphorus, increased potassium

Frequency not reported: False positive glycosuria

Nervous system

Higher doses (2 grams every 8 hours) have been associated with a higher incidence of side effects, including headache.

Encephalopathy included coma, confusion, consciousness disorder, hallucinations, and stupor.

Coma, consciousness disorder, convulsions, encephalopathy, myoclonus, and stupor were reported with cephalosporin use.

Common (1% to 10%): Headache

Rare (0.01% to 0.1%): Convulsions, dizziness, dysgeusia, paresthesia, taste perversion

Very rare (less than 0.01%): Seizures

Frequency not reported: Altered state of consciousness/consciousness disorder, coma, encephalopathy, myoclonus, neurotoxicity, stupor

Postmarketing reports: Aphasia, nonconvulsive status epilepticus

Respiratory

Rare (0.01% to 0.1%): Dyspnea

Renal

Renal failure and toxic nephropathy were reported with cephalosporin use.

Uncommon (0.1% to 1%): Blood creatinine increased/increased creatinine, blood urea increased/increased blood urea nitrogen (BUN), transient increase in serum creatinine, transient increase in serum urea, transient uremia

Frequency not reported: Renal dysfunction, renal failure, toxic nephropathy

Genitourinary

Uncommon (0.1% to 1%): Vaginal infection, vaginitis

Rare (0.01% to 0.1%): Genital pruritus

Hypersensitivity

Rare (0.01% to 0.1%): Anaphylactic reaction, angioedema

Frequency not reported: Anaphylactic shock, anaphylaxis, hypersensitivity reactions

Anaphylactic shock and anaphylaxis were reported with cephalosporin use.

Immunologic

Rare (0.01% to 0.1%): Candidiasis, unspecified moniliasis

Psychiatric

Confusion and hallucinations were reported with cephalosporin use.

Frequency not reported: Confusion/state of confusion, hallucinations

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Cefepime (www.drugs.com/mtm/cefepime-injection.html).