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Cefaclor

Generic Name: Cefaclor Capsules (SEFF uh klor)
Easy-to-read patient leaflet for Cefaclor Capsules. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This medicine may interact with other drugs or health problems. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (cefaclor capsules) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use this medicine (cefaclor capsules) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

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Cefaclor Side Effects

For the Consumer

Applies to cefaclor: oral capsules, oral extended-release tablets, oral for suspension

Side effects include:

Diarrhea, genital pruritus or vaginitis, headache, nausea, vomiting, rash.

For Healthcare Professionals

Applies to cefaclor: oral capsule, oral powder for reconstitution, oral tablet chewable, oral tablet extended release

General

ER TABLETS: The most commonly reported side effects included headache, rhinitis, diarrhea, and nausea.

IR CAPSULES: The most commonly reported side effects included abdominal pain, diarrhea, morbilliform eruptions, and hypersensitivity reactions.

CR/MR TABLETS: The most commonly reported side effects included headache, diarrhea, nausea, and vaginal moniliasis.

ORAL SUSPENSION: The most commonly reported side effects included diarrhea and hypersensitivity reactions.

Gastrointestinal

ER TABLETS:

Common (1% to 10%): Abdominal pain, diarrhea, nausea

Uncommon (0.1% to 1%): Constipation, dyspepsia, flatulence, gastritis, nausea and vomiting, vomiting

Postmarketing reports: Pseudomembranous colitis symptoms

IR CAPSULES:

Common (1% to 10%): Diarrhea

Rare (0.01% to 0.1%): Nausea, vomiting

Frequency not reported: Abdominal pain, colitis, pseudomembranous colitis

CR/MR TABLETS:

Common (1% to 10%): Abdominal pain, diarrhea, nausea

Frequency not reported: Colitis, dyspepsia, pseudomembranous colitis, vomiting

ORAL SUSPENSION:

Common (1% to 10%): Diarrhea, gastrointestinal symptoms

Rare (0.01% to 0.1%): Colitis, pseudomembranous colitis, nausea, vomiting

Frequency not reported: Abdominal pain

Dermatologic

ER TABLETS:

Common (1% to 10%): Pruritus

Uncommon (0.1% to 1%): Maculopapular rash, rash, sweating, urticaria

Frequency not reported: Erythema multiforme

Postmarketing reports: Face edema, Stevens-Johnson syndrome, toxic epidermal necrolysis

IR CAPSULES:

Common (1% to 10%): Morbilliform eruption

Very rare (less than 0.01%): Pruritus, urticaria

Frequency not reported: Erythema multiforme, face edema, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis

CR/MR TABLETS:

Common (1% to 10%): Pruritus, rash, urticaria

Frequency not reported: Erythema multiforme, erythema multiforme minor, face edema, morbilliform eruptions, Stevens-Johnson syndrome, toxic epidermal necrolysis

ORAL SUSPENSION:

Common (1% to 10%): Morbilliform eruptions

Uncommon (0.1% to 1%): Erythema multiforme, pruritus, rash, urticaria

Rare (0.01% to 0.1%): Erythema multiforme major, Stevens-Johnson syndrome, toxic epidermal necrolysis

Frequency not reported: Erythema multiforme minor, face edema

Genitourinary

ER TABLETS:

Common (1% to 10%): Vaginal moniliasis, vaginitis

Uncommon (0.1% to 1%): Dysmenorrhea, dysuria, leukorrhea, menstrual disorder, nocturia

Postmarketing reports: Abnormal urinalysis, genital pruritus

IR CAPSULES:

Frequency not reported: Abnormal urinalysis, false positive test for urinary glucose, genital pruritus, vaginal moniliasis, vaginitis

CR/MR TABLETS:

Common (1% to 10%): Vaginal moniliasis, vaginitis

Frequency not reported: Abnormal urinalysis, genital pruritus, hematuria, proteinuria, pyuria

ORAL SUSPENSION:

Frequency not reported: Abnormal urinalysis, false positive test for urinary glucose, genital pruritus, hematuria, proteinuria, pyuria, vaginal moniliasis, vaginitis

Respiratory

ER TABLETS:

Common (1% to 10%): Cough increased, pharyngitis, rhinitis

Uncommon (0.1% to 1%): Asthma, bronchitis, lung disorder, respiratory disorder, sinusitis

IR CAPSULES:

Frequency not reported: Dyspnea

CR/MR TABLETS:

Common (1% to 10%): Epistaxis

Frequency not reported: Dyspnea

ORAL SUSPENSION:

Frequency not reported: Dyspnea

Hypersensitivity

ER TABLETS:

Uncommon (0.1% to 1%): Serum sickness-like reaction

Frequency not reported: Hypersensitivity reactions, severe hypersensitivity reactions

Postmarketing reports: Allergic reaction, anaphylactoid events, anaphylaxis, angioedema

IR CAPSULES:

Common (1% to 10%): Hypersensitivity reactions

Uncommon (0.1% to 1%): Serum sickness-like reaction

Frequency not reported: Anaphylactoid events, anaphylaxis, angioedema, severe hypersensitivity reactions

CR/MR TABLETS:

Rare (0.01% to 0.1%): Serum sickness-like reaction

Frequency not reported: Allergic reactions, anaphylactoid events, anaphylaxis, angioedema, severe hypersensitivity reactions

ORAL SUSPENSION:

Common (1% to 10%): Hypersensitivity reactions

Uncommon (0.1% to 1%): Serum sickness-like reactions

Rare (0.01% to 0.1%): Anaphylaxis, angioedema

Frequency not reported: Anaphylactoid events

Anaphylaxis may occur more frequently in patients with a history of penicillin allergy.

Hypersensitivity reaction symptoms may persist for several months.

Serum-sickness-like reactions were more frequently reported in pediatric patients and after a second/subsequent course of treatment; reactions have been characterized by arthritis/arthralgia, erythema multiforme, and rash with or without fever.

Musculoskeletal

ER TABLETS:

Common (1% to 10%): Back pain

Uncommon (0.1% to 1%): Arthralgia, creatine phosphokinase increased, myalgia, neck pain, somnolence

Frequency not reported: Arthritis

IR CAPSULES:

Frequency not reported: Arthralgia, arthritis

CR/MR TABLETS:

Frequency not reported: Arthralgia, arthritis

ORAL SUSPENSION:

Frequency not reported: Arthralgia, arthritis

Nervous system

ER TABLETS:

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Dizziness, somnolence, tremor

Postmarketing reports: Hypertonia, paresthesia, reversible hyperactivity, syncope, vertigo

IR CAPSULES:

Rare (0.01% to 0.1%): Dizziness, hypertonia, reversible hyperactivity, somnolence

Frequency not reported: Paresthesia, seizures, syncope

CR/MR TABLETS:

Common (1% to 10%): Headache

Frequency not reported: Dizziness, hypertonia, paresthesia, reversible hyperactivity, seizures, somnolence, syncope

ORAL SUSPENSION:

Rare (0.01% to 0.1%): Dizziness, hypertonia, reversible hyperactivity, somnolence

Frequency not reported: Paresthesia, seizures, syncope

Hematologic

ER TABLETS:

Uncommon (0.1% to 1%): Eosinophils increased, erythrocyte count decreased, hemoglobin decreased, lymphocytes decreased, mean cell volume (MCV) increased, neutrophils segmented decreased, platelet count decreased

Postmarketing reports: Eosinophilia, hemolytic anemia, leukopenia, neutropenia, positive direct Coombs test, transient thrombocytopenia

IR CAPSULES:

Rare (0.01% to 0.1%): Agranulocytosis, aplastic anemia, hemolytic anemia, reversible neutropenia (may be of clinical significance), thrombocytopenia

Very rare (less than 0.01%): Positive Coombs test

Frequency not reported: Eosinophilia, pancytopenia, transient leukopenia, transient lymphocytosis

Postmarketing reports: Increased prothrombin time with/without clinical bleeding

CR/MR TABLETS:

Frequency not reported: Agranulocytosis, aplastic anemia, eosinophilia, hemolytic anemia, increased prothrombin time with/without clinical bleeding, leukopenia, lymphadenopathy, lymphocytosis, neutropenia (may be of clinical significance), positive direct Coombs test, transient fluctuations in leukocyte count, transient thrombocytopenia

ORAL SUSPENSION:

Uncommon (0.1% to 1%): Positive Coombs test

Rare (0.01% to 0.1%): Agranulocytosis, aplastic anemia, hemolytic anemia, reversible neutropenia (may be of clinical significance), thrombocytosis, thrombocytopenia

Frequency not reported: Eosinophilia, leukopenia, lymphadenopathy, pancytopenia, transient fluctuations in leukocyte count, transient lymphocytosis

Postmarketing reports: Increased prothrombin time with/without clinical bleeding

Increased prothrombin time with/without clinical bleeding was reported in patients given IR capsules and warfarin concurrently.

Transient fluctuations in leukocyte count most commonly occurred in infants and young children.

Other

ER TABLETS:

Uncommon (0.1% to 1%): Accidental injury, chills, ear pain, fever, malaise, otitis media, pain, surgical procedure

IR CAPSULES:

Frequency not reported: Asthenia, fever

CR/MR TABLETS:

Common (1% to 10%): Asthenia, pain

Frequency not reported: Fever

ORAL SUSPENSION:

Rare (0.01% to 0.1%): Fever

Frequency not reported: Asthenia

Metabolic

ER TABLETS:

Uncommon (0.1% to 1%): Albumin decreased, anorexia, calcium increased, phosphorus increased, potassium increased, sodium decreased/increased

Hepatic

ER TABLETS:

Uncommon (0.1% to 1%): Alkaline phosphatase increased, ALT increased, GGT increased, total bilirubin increased

Postmarketing reports: Cholestasis, liver dysfunction, transient AST elevation

IR CAPSULES:

Rare (0.01% to 0.1%): Cholestatic jaundice, transient hepatitis

Frequency not reported: Elevated bilirubin, elevated LDH, slight alkaline phosphatase elevations, slight ALT elevations, slight AST elevations

CR/MR TABLETS:

Frequency not reported: Cholestasis, cholestatic jaundice, liver dysfunction, transient alkaline phosphatase elevations, transient ALT elevations, transient AST elevations, transient hepatitis

ORAL SUSPENSION:

Rare (0.01% to 0.1%): Cholestatic jaundice, liver dysfunction, transient hepatitis

Frequency not reported: Elevated bilirubin, elevated LDH, slight alkaline phosphatase elevations, slight ALT elevations, slight AST elevations

Cardiovascular

EXTENDED RELEASE (ER) TABLETS:

Uncommon (0.1% to 1%): Chest pain, congestive heart failure, edema, palpitation, peripheral edema

Postmarketing reports: Hypotension, limb edema, vasodilation

IMMEDIATE RELEASE (IR) CAPSULES:

Frequency not reported: Hemorrhage, hypotension, limb edema, vasodilation

MODIFIED RELEASE (CR/MR) TABLETS:

Frequency not reported: Limb edema, vasodilation

ORAL SUSPENSION:

Frequency not reported: Hemorrhage, hypotension, limb edema, vasodilation

Psychiatric

ER TABLETS:

Uncommon (0.1% to 1%): Anxiety, insomnia, nervousness

Postmarketing reports: Confusion

IR CAPSULES:

Rare (0.01% to 0.1%): Agitation, confusion, hallucinations, insomnia, nervousness

CR/MR TABLETS:

Frequency not reported: Agitation, confusion, hallucinations, insomnia, nervousness

ORAL SUSPENSION:

Rare (0.01% to 0.1%): Agitation, confusion, hallucinations, insomnia, nervousness

Renal

ER TABLETS:

Uncommon (0.1% to 1%): Blood urea nitrogen (BUN) increased, creatinine increased

Postmarketing reports: Reversible interstitial nephritis

IR CAPSULES:

Rare (0.01% to 0.1%): Reversible interstitial nephritis

Frequency not reported: Renal dysfunction, slight BUN elevations, slight serum creatinine elevations, toxic nephropathy

CR/MR TABLETS:

Frequency not reported: Renal dysfunction, reversible interstitial nephritis, toxic nephropathy, transient serum creatinine increase, transient serum urea/BUN increase

ORAL SUSPENSION:

Rare (0.01% to 0.1%): Reversible interstitial nephritis

Frequency not reported: Renal dysfunction, slight elevation in serum creatinine, slight elevation in serum urea/BUN, toxic nephropathy

Ocular

ER TABLETS:

Uncommon (0.1% to 1%): Conjunctivitis

Immunologic

ER TABLETS:

Uncommon (0.1% to 1%): Flu syndrome, infection

IR CAPSULES:

Frequency not reported: Moniliasis, superinfection

CR/MR TABLETS:

Frequency not reported: Moniliasis

ORAL SUSPENSION:

Frequency not reported: Moniliasis, superinfection

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Cefaclor (www.drugs.com/cefaclor.html).

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