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Note: This document contains side effect information about clonidine. Some of the dosage forms listed on this page may not apply to the brand name Catapres.
For the ConsumerApplies to clonidine: oral tablet, oral tablet extended release
Other dosage forms:
Along with its needed effects, clonidine (the active ingredient contained in Catapres) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking clonidine:
Less common
Rare
Get emergency help immediately if any of the following symptoms of overdose occur while taking clonidine:
Symptoms of overdose
Some side effects of clonidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Rare
For Healthcare Professionals
Applies to clonidine: compounding powder, injectable solution, oral suspension extended release, oral tablet, oral tablet extended release, transdermal film extended release
CardiovascularVery common (10% or more): Hypotension (45%), orthostatic hypotension (32%)
Common (1% to 10%): Chest pain, tachycardia
Uncommon (0.1% to 1%): Sinus bradycardia, Raynaud's phenomenon, palpitations
Rare (0.01% to 0.1%): Atrioventricular block, palpitations, bradycardia, syncope, congestive heart failure, electrocardiographic abnormalities (i.e., sinus node arrest, high degree AV block), cerebrovascular accident
Frequency not reported: Bradyarrhythmia, hypertension, rebound hypertension
DermatologicVery common (10% or more): Contact dermatitis with the patch formulation (19%)
Common (1% to 10%): Sweating
Uncommon (0.1% to 1%): Pruritus, rash (localized or generalized), urticaria, erythema
Rare (0.01% to 0.1%): Alopecia, excoriation, burning
Very rare (less than 0.01%): Papules, throbbing, blanching, generalized macular rash, facial/tongue angioedema
Frequency not reported: Hives, localized hypo or hyper pigmentation
EndocrineRare (0.01% to 0.1%): Gynecomastia
GastrointestinalVery common (10% or more): Dry mouth (40%), upper abdominal pain (15%), nausea (13%), vomiting (10%)
Common (1% to 10%): Constipation, parotid gland pain
Uncommon (0.1% to 1%): Colonic pseudo-obstruction
Very rare (less than 0.01%): Parotitis
GenitourinaryCommon (1% to 10%): Erectile dysfunction
Frequency not reported: Micturition difficulty, loss of libido, decreased sexual activity, nocturia, urinary retention
GeneralMost adverse effects are mild and diminish with continued therapy. The most frequent (which appear to be dose-related) are dry mouth (40%), drowsiness (33%), dizziness (16%), constipation (10%), and sedation (10%).
HematologicRare (0.01% to 0.1%): Peripheral blood flow disturbance, thrombocytopenia
HepaticFrequency not reported: Mild transient abnormalities of liver function tests, hepatitis
MetabolicRare (0.01% to 0.1%): Blood glucose increased, serum creatine phosphokinase increased
Frequency not reported: Weight gain, anorexia
MusculoskeletalFrequency not reported: Muscle pain, joint pain, leg cramps
Nervous systemVery common (10% or more): Drowsiness (33%), dizziness (16%), somnolence (13%), sedation (10%)
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Paresthesia
Frequency not reported: Headache, localized numbness
OcularRare (0.01% to 0.1%): Lacrimation decreased (dry eyes)
Frequency not reported: Accommodation disorder, ocular burning, vision blurred
OtherCommon (1% to 10%): Fatigue, tinnitus
Uncommon (0.1% to 1%): Malaise
Frequency not reported: Fever, pallor, weakness, positive Coombs' test, increased sensitivity to alcohol
PsychiatricVery common (10% or more): Confusion (13%)
Common (1% to 10%): Depression, tearfulness, sleep disorder, hallucinations (both visual and auditory), nervousness, agitation
Uncommon (0.1% to 1%):
Rare (0.01% to 0.1%): Delusional perception, nightmare
Frequency not reported: Libido decreased, restlessness, anxiety, irritability, behavior changes
RespiratoryCommon (1% to 10%): Hypoventilation
Rare (0.01% to 0.1%): Nasal dryness
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Catapres-tts-3 (www.drugs.com/catapres.html).
August 4, 2022
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