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Carboplatin

Generic Name: carboplatin (KAR boe PLA tin)
Brand Name: Paraplatin, CARBOplatin Novaplus
Physician reviewed carboplatin patient information - includes carboplatin description, dosage and directions.
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Drug Information:
Carboplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. Carboplatin is used together with other cancer medications to treat ovarian cancer. Carboplatin may also be used for purposes not listed in this medication guide. Carboplatin is a cancer medication used in chemoTherapy combinations to treat ovarian cancer. You should not receive carboplatin if you have severe bleeding or bone marrow suppression. Carboplatin can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before you receive carboplatin, tell your doctor about all other medications you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys. Learn more

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Carboplatin Side Effects

In Summary

Commonly reported side effects of carboplatin include: hypersensitivity reaction, nausea and vomiting, anemia, vomiting, and genitourinary signs and symptoms. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to carboplatin: intravenous powder for solution, intravenous solution

Warning

Intravenous route (Solution; Powder for Solution)

Bone marrow suppression with carboplatin is dose-related and may be severe, resulting in infection and/or bleeding. Anemia may be cumulative and may require transfusion support. Vomiting is another frequent drug-related side effect. Anaphylactic-like reactions to carboplatin have been reported and may occur within minutes of carboplatin administration.

Along with its needed effects, carboplatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Check with your doctor as soon as possible if any of the following side effects occur while taking carboplatin:

More common

  • Pain at place of injection

Less common

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness, accompanied by fever or chills
  • fever or chills
  • lower back or side pain, accompanied by fever or chills
  • numbness or tingling in fingers or toes
  • painful or difficult urination, accompanied by fever or chills
  • pinpoint red spots on skin
  • skin rash or itching
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Rare

  • Blurred vision
  • ringing in ears
  • sores in mouth and on lips
  • wheezing

Some side effects of carboplatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Nausea and vomiting
  • unusual tiredness or weakness

Less common

  • Constipation or diarrhea
  • loss of appetite

This medicine may cause a temporary loss of hair in some people. After treatment with carboplatin has ended, normal hair growth should return.

For Healthcare Professionals

Applies to carboplatin: intravenous powder for injection, intravenous solution

Hematologic

Very common (10% or more): Leukopenia (98%), neutropenia (97%), anemia (91%), thrombocytopenia (70%), bleeding (10%)

Rare (less than 0.1%): Febrile neutropenia

Frequency not reported: Bone marrow failure, hemolytic-uremic syndrome

Gastrointestinal

Very common (10% or more): Nausea (93%), vomiting (84%), adverse GI effects (50%), abdominal pain

Common (1% to 10%): Mucositis, diarrhea, constipation

Frequency not reported: Stomatitis, pancreatitis

Nervous system

Very common (10% or more): Central neurotoxicity (26%), peripheral neuropathy (15%)

Common (1% to 10%): Other sensory side effects, paresthesia, decrease of osteotendinous reflexes, sensory disturbance, dysgeusia

Frequency not reported: Cerebrovascular accident, reversible posterior leukoencephalopathy syndrome (RPLS)

Hepatic

Very common (10% or more): Alkaline phosphatase elevations (29%), SGOT elevations (20%), aspartate aminotransferase increased, liver function test abnormal

Common (1% to 10%): Bilirubin elevations

Renal

Very common (10% or more): Blood urea elevations (17%), creatinine renal clearance decreased

Other

Very common (10% or more): Pain (44%), asthenia (41%), ototoxicity (12%)

Common (1% to 10%): Asthenia

Frequency not reported: Malaise

Hypersensitivity

Common (1% to 10%): Hypersensitivity, anaphylactoid type reaction

Metabolic

Very common (10% or more): Magnesium loss (61%), potassium loss (16%), calcium loss (16%), sodium loss (10%)

Rare (less than 0.1%): Hyponatremia

Frequency not reported: Dehydration, anorexia, tumor lysis syndrome

Ocular

Rare (less than 0.1%): Visual disturbance (including rare cases of loss of vision)

Immunologic

Very common (10% or more): Infection (14%)

Local

Frequency not reported: Injection site necrosis, injection site reaction, injection site extravasation, injection site erythema

Musculoskeletal

Common (1% to 10%): Musculoskeletal disorder

Genitourinary

Common (1% to 10%): Urogenital disorder

Oncologic

Frequency not reported: Neoplasms (e.g., benign, malignant, unspecified) including cysts and polyps

Respiratory

Common (1% to 10%): Respiratory disorder, interstitial lung disease, bronchospasm

Frequency not reported: Pneumonia

Cardiovascular

Common (1% to 10%): Cardiovascular disorder

Frequency not reported: Cardiac failure, embolism, hypertension, hypotension

Dermatologic

Very common (10% or more): Alopecia (49%), skin disorder

Frequency not reported: Urticaria, rash, erythema, pruritus

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Carboplatin (www.drugs.com/mtm/carboplatin.html).