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Carboplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.
Carboplatin is used together with other cancer medications to treat ovarian cancer.
Carboplatin may also be used for purposes not listed in this medication guide.
Carboplatin is a cancer medication used in chemotherapy combinations to treat ovarian cancer.
You should not receive carboplatin if you have severe bleeding or bone marrow suppression.
Carboplatin can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before you receive carboplatin, tell your doctor about all other medications you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys.
Carboplatin can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).
You should not receive this medication if you are allergic to carboplatin or similar medications such as oxaliplatin (Eloxatin) or cisplatin (Platinol). You should not receive carboplatin if you have severe bleeding or bone marrow suppression.
To make sure carboplatin is safe for you, tell your doctor if you have:
liver disease;
kidney disease;
a weak immune system; or
if you have received carboplatin in the past.
Do not use carboplatin if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.
It is not known whether carboplatin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while being treated with carboplatin.
Carboplatin is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.
Carboplatin is usually given once every 4 weeks. Follow your doctor's instructions.
You may be given other medications to prevent nausea or vomiting while you are receiving carboplatin.
Carboplatin can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Your kidney and liver function may also need to be tested.
You may need to receive blood transfusions while you are being treated with carboplatin.
Call your doctor if you miss an appointment for your carboplatin injection.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Carboplatin can cause side effects that may impair your vision. Be careful if you drive or do anything that requires you to be able to see clearly.
carboplatin can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
fever, chills, body aches, flu symptoms, sores in your mouth and throat;
severe or ongoing vomiting;
stomach pain, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
numbness or tingly feeling in your hands or feet;
hearing or vision problems;
skin changes where the medicine was injected; or
low magnesium (confusion, uneven heart rate, jerking muscle movements, muscle weakness or limp feeling).
Common side effects may include:
nausea, vomiting, loss of appetite;
tired feeling;
temporary hair loss; or
pain, swelling or redness where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Carboplatin can harm your kidneys. This effect is increased when you also use certain other medicines, including: antivirals, chemotherapy, injected antibiotics, medicine for bowel disorders, medicine to prevent organ transplant rejection, and some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).
This list is not complete. Other drugs may interact with carboplatin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Carboplatin (www.drugs.com/mtm/carboplatin.html).
Commonly reported side effects of carboplatin include: hypersensitivity reaction, nausea and vomiting, anemia, vomiting, and genitourinary signs and symptoms. See below for a comprehensive list of adverse effects.
Applies to carboplatin: intravenous powder for solution, intravenous solution
Intravenous route (Solution; Powder for Solution)
Bone marrow suppression with carboplatin is dose-related and may be severe, resulting in infection and/or bleeding. Anemia may be cumulative and may require transfusion support. Vomiting is another frequent drug-related side effect. Anaphylactic-like reactions to carboplatin have been reported and may occur within minutes of carboplatin administration.
Along with its needed effects, carboplatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.
Check with your doctor as soon as possible if any of the following side effects occur while taking carboplatin:
More common
Less common
Rare
Some side effects of carboplatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
This medicine may cause a temporary loss of hair in some people. After treatment with carboplatin has ended, normal hair growth should return.
Applies to carboplatin: intravenous powder for injection, intravenous solution
Very common (10% or more): Leukopenia (98%), neutropenia (97%), anemia (91%), thrombocytopenia (70%), bleeding (10%)
Rare (less than 0.1%): Febrile neutropenia
Frequency not reported: Bone marrow failure, hemolytic-uremic syndrome
Very common (10% or more): Nausea (93%), vomiting (84%), adverse GI effects (50%), abdominal pain
Common (1% to 10%): Mucositis, diarrhea, constipation
Frequency not reported: Stomatitis, pancreatitis
Very common (10% or more): Central neurotoxicity (26%), peripheral neuropathy (15%)
Common (1% to 10%): Other sensory side effects, paresthesia, decrease of osteotendinous reflexes, sensory disturbance, dysgeusia
Frequency not reported: Cerebrovascular accident, reversible posterior leukoencephalopathy syndrome (RPLS)
Very common (10% or more): Alkaline phosphatase elevations (29%), SGOT elevations (20%), aspartate aminotransferase increased, liver function test abnormal
Common (1% to 10%): Bilirubin elevations
Very common (10% or more): Blood urea elevations (17%), creatinine renal clearance decreased
Very common (10% or more): Pain (44%), asthenia (41%), ototoxicity (12%)
Common (1% to 10%): Asthenia
Frequency not reported: Malaise
Common (1% to 10%): Hypersensitivity, anaphylactoid type reaction
Very common (10% or more): Magnesium loss (61%), potassium loss (16%), calcium loss (16%), sodium loss (10%)
Rare (less than 0.1%): Hyponatremia
Frequency not reported: Dehydration, anorexia, tumor lysis syndrome
Rare (less than 0.1%): Visual disturbance (including rare cases of loss of vision)
Very common (10% or more): Infection (14%)
Frequency not reported: Injection site necrosis, injection site reaction, injection site extravasation, injection site erythema
Common (1% to 10%): Musculoskeletal disorder
Common (1% to 10%): Urogenital disorder
Frequency not reported: Neoplasms (e.g., benign, malignant, unspecified) including cysts and polyps
Common (1% to 10%): Respiratory disorder, interstitial lung disease, bronchospasm
Frequency not reported: Pneumonia
Common (1% to 10%): Cardiovascular disorder
Frequency not reported: Cardiac failure, embolism, hypertension, hypotension
Very common (10% or more): Alopecia (49%), skin disorder
Frequency not reported: Urticaria, rash, erythema, pruritus
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Carboplatin (www.drugs.com/mtm/carboplatin.html).
March 28, 2020
March 28, 2020
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