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Carbidopa

Generic Name: carbidopa (kar bi DOE pa)
Brand Name: Lodosyn
Physician reviewed carbidopa patient information - includes carbidopa description, dosage and directions.
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Drug Information:
Carbidopa is used with another medicine called Levodopa to treat the symptoms of Parkinson's disease (stiffness, tremors, spasms, poor muscle control). Symptoms of Parkinson's disease may be caused by low levels of a chemical called dopamine (DOE pa meen) in the brain. Levodopa is converted to dopamine in the brain. Carbidopa helps prevent the breakdown of Levodopa before it can reach the brain and take effect. Carbidopa is only used in combination with Levodopa. Carbidopa has no effect when used alone. Learn more

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Carbidopa Side Effects

For the Consumer

Applies to carbidopa: oral tablet

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
  • Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Change in the way you act.
  • Hallucinations (seeing or hearing things that are not there).
  • Feeling confused.
  • Strong urges that are hard to control (such as eating, gambling, sex, or spending money).
  • Throwing up blood or throw up that looks like coffee grounds.
  • Black, tarry, or bloody stools.
  • Belly pain.
  • A burning, numbness, or tingling feeling that is not normal.
  • Any unexplained bruising or bleeding.
  • Chest pain or pressure.
  • A heartbeat that does not feel normal.
  • Fever or chills.
  • Sore throat.
  • A skin lump or growth.
  • Change in color or size of a mole.
  • Change in eyesight, eye pain, or very bad eye irritation.
  • Trouble controlling body movements that is new or worse.
  • Grinding of teeth.
  • Shortness of breath.
  • Feeling very tired or weak.
  • Swelling in the arms or legs.
  • A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Headache.
  • Dry mouth.
  • Feeling sleepy.
  • Not able to sleep.
  • Upset stomach or throwing up.
  • Change in taste.
  • Constipation.
  • Diarrhea.
  • Not hungry.
  • Strange or odd dreams.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to carbidopa: compounding powder, oral tablet

General

In general, side effects have not been observed when carbidopa is administered alone. All side effects listed have been reported during concomitant use with levodopa or with carbidopa-levodopa therapy. The most common side effects included dyskinesias and nausea.

Nervous system

Symptoms related to neuroleptic malignant syndrome are characterized by fever or hyperthermia. Other findings include neurological symptoms such as muscle rigidity, involuntary movements, altered consciousness, mental status changes, other disturbances such as autonomic dysfunction, tachycardia, tachypnea, sweating, hyper- or hypotension, and laboratory findings such as elevated creatine phosphokinase, leukocytosis, myoglobinuria, and increased serum myoglobin.

A causal relationship with concomitant carbidopa and levodopa and the reported side effect of convulsions has not been established.

Frequency not reported: Bradykinetic episodes ("on-off" phenomenon), convulsions, dizziness, dyskinesias such as choreiform, dystonic and other involuntary movements, headache, neuroleptic malignant syndrome, oculogyric crises, paresthesia, peripheral neuropathy, somnolence, syncope, taste alterations

Psychiatric

Frequency not reported: Agitation, bruxism, confusion, dementia, depression with or without development of suicidal tendencies, dream abnormalities (including nightmares), impulse control symptoms, increased libido (including hypersexuality), insomnia, pathological gambling, psychotic episodes (including delusions, hallucinations and paranoid ideation)

Psychiatric side effects were reported with concomitant administration of levodopa or carbidopa-levodopa.

Cardiovascular

Frequency not reported: Cardiac irregularities, chest pain, hot flashes, hypertension, hypotension (including orthostatic hypotension), myocardial infarction, palpitation, phlebitis

Gastrointestinal

Frequency not reported: Abdominal pain and distress, burning sensation of the tongue, constipation, dark saliva, development of duodenal ulcer, diarrhea, dry mouth, dyspepsia, dysphagia, flatulence, gastrointestinal bleeding, gastrointestinal pain, heartburn, hiccups, nausea, sialorrhea, vomiting

Hematologic

Frequency not reported: Abnormal Coombs test, agranulocytosis, decreased hemoglobin and hematocrit, decreased white blood cell count, hemolytic and nonhemolytic anemia, leukopenia, thrombocytopenia

Metabolic

Frequency not reported: Abnormal lactic dehydrogenase, anorexia, edema, elevated serum glucose, elevated serum potassium, weight gain, weight loss

Musculoskeletal

Frequency not reported: Back pain, leg pain, muscle cramps, shoulder pain

Respiratory

Frequency not reported: Bizarre breathing patterns, cough, dyspnea, pharyngeal pain, upper respiratory infection

Dermatologic

Frequency not reported: Alopecia, angioedema, bullous lesions (including pemphigus-like reactions), dark sweat, flushing, Henoch-Schonlein purpura, increased sweating, malignant melanoma, pruritus, rash, urticaria

Ocular

Frequency not reported: Blurred vision, dilated pupils, diplopia

Genitourinary

Frequency not reported: Dark urine, priapism, urinary frequency, urinary incontinence, urinary retention, urinary tract infection

Other

Frequency not reported: Asthenia, faintness, fatigue, hoarseness, malaise, sense of stimulation

Hepatic

Frequency not reported: Abnormalities in alkaline phosphatase, SGOT (AST), SGPT (ALT), and bilirubin.

Renal

Frequency not reported: Abnormal blood urea nitrogen (BUN), increased serum creatinine and uric acid, protein and glucose in the urine, white blood cells, bacteria and blood in the urine,

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Carbidopa (www.drugs.com/mtm/carbidopa.html).