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Captopril

Captopril Prescription
Generic Name: captopril (KAP toe pril)
Brand Names: Capoten
Captopril is used to treat hypertension, heart failure and to improve survival after a heart attack. Learn about side effects, interactions and indications.

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Captopril Drug Information:

Captopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Captopril is used to treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by Diabetes, and to improve survival after a heart attack. Captopril may also be used for purposes not listed in this medication guide. Do not use captopril if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. If you have Diabetes, do not use captopril together with any medication that contains Aliskiren (Amturnide, Tekturna, Tekamlo). Learn more

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Captopril Side Effects

In Summary

More frequently reported side effects include: cough and skin rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to captopril: oral tablet

Warning

Oral route (Tablet)

When pregnancy is detected, discontinue captopril as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Along with its needed effects, captopril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking captopril:

Less common

  • Chest pain
  • cloudy urine
  • fast, pounding, or irregular heartbeat or pulse

Rare

  • Arm, back, or jaw pain
  • bloody urine
  • chest discomfort
  • chest tightness or heaviness
  • decreased blood pressure
  • decreased or increased frequency or amount of urine
  • dilated neck veins
  • increased thirst
  • irregular breathing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • low blood pressure
  • lower back or side pain
  • nausea
  • paleness or cold feeling in the fingertips and toes
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • tingling or pain in the fingers or toes when exposed to cold temperatures
  • troubled breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain

Incidence not known

  • Bleeding gums
  • bloody, black, or tarry stools
  • blurred vision
  • chills
  • confusion
  • cough
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • high fever
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • unusual bleeding or bruising

Some side effects of captopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Change in taste
  • feeling of warmth
  • itching skin
  • loss of taste
  • rash
  • redness of the face, neck, arms, and occasionally, upper chest

For Healthcare Professionals

Applies to captopril: compounding powder, oral tablet

General

The most common side effect is rash.

Dermatologic

Very common (10% or more): Rash (up to 13.1%)

Common (1% to 10%): Pruritus, alopecia

Uncommon (0.1% to 1%): Angioedema

Very rare (less than 0.01%): Urticaria, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, erythroderma, pemphigoid reactions, exfoliative dermatitis

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, abdominal pain, dry mouth, diarrhea, constipation, gastric irritation

Rare (0.01% to 0.1%): Stomatitis/aphthous ulceration, mouth ulcers, intestinal angioedema

Very rare (less than 0.01%): Glossitis, peptic ulcer, pancreatitis

Nervous system

Common (1% to 10%): Dizziness, taste impairment, loss of taste

Rare (0.01% to 0.1%): Paresthesia, headache, drowsiness

Very rare (less than 0.01%): Cerebrovascular incidents

Frequency not reported: Syncope, ataxia, somnolence

Respiratory

Common (1% to 10%): Cough, dyspnea

Rare (0.01% to 0.1%): Bronchospasm

Very rare (less than 0.01%): Rhinitis, allergic alveolitis/eosinophilic pneumonia

Cardiovascular

Common (1% to 10%): Hypotension

Uncommon (0.1% to 1%): Tachycardia or tachyarrhythmia, angina pectoris, palpitations, Raynaud's syndrome, flushing, pallor, myocardial infarction, congestive heart failure

Very rare (less than 0.01%): Cardiac arrest, cardiogenic shock

Frequency not reported: Rhythm disturbances, orthostatic hypotension

Genitourinary

Common (1% to 10%): Proteinuria

Uncommon (0.1% to 1%): Polyuria, oliguria, urinary frequency

Rare (less than 0.1%): Impotence

Psychiatric

Common (1% to 10%): Sleep disorder

Rare (0.01% to 0.1%): Loss of libido

Very rare (less than 0.01%): Confusion, depression

Frequency not reported: Nervousness

Other

Uncommon (0.1% to 1%): Chest pain, fatigue, malaise

Very rare (less than 0.01%): Gynecomastia, fever

Frequency not reported: Asthenia, alkaline phosphatase elevated

Renal

Uncommon (0.1% to 1%): Renal insufficiency, acute renal failure, nephrotic syndrome

Very rare (less than 0.01%): BUN elevated, serum creatinine elevated

Frequency not reported: Glomerulopathy

Metabolic

Rare (0.01% to 0.1%): Anorexia, weight loss, loss of appetite

Very rare (less than 0.01%): Hyperkalemia, hypoglycemia, serum potassium increased, serum sodium decreased

Frequency not reported: Hyponatremia

Ocular

Rare (0.01% to 0.1%): Disturbed vision, dry eye, itchy eye

Very rare (less than 0.01%): Blurred vision

Hematologic

Very rare (less than 0.01%): Neutropenia/agranulocytosis, pancytopenia, anemia, thrombocytopenia, lymphadenopathy, eosinophilia, hemoglobin decreased, hematocrit decreased, leukocytes decreased, thrombocytes decreased, erythrocyte sedimentation rate elevated

Hepatic

Very rare (less than 0.01%): Liver enzymes elevated, bilirubin elevated, impaired hepatic function, cholestasis, hepatitis

Frequency not reported: Jaundice

Immunologic

Very rare (less than 0.01%): Autoimmune disease, positive antinuclear antibody titer

Frequency not reported: Serum sickness-like syndrome, anaphylactoid reactions

Musculoskeletal

Very rare (less than 0.01%): Myalgia, arthralgia

Frequency not reported: Myasthenia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Captopril (www.drugs.com/captopril.html).

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