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Capastat sulfate

Generic Name: capreomycin (KAP ree oh MYE sin)
Brand Name: Capastat Sulfate
Physician reviewed Capastat Sulfate patient information - includes Capastat Sulfate description, dosage and directions.
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Drug Information:
Capastat Sulfate is an antibiotic that fights bacteria in the body. Capastat Sulfate is used in combination with other medicines to treat Mycobacterium tuberculosis. Capastat Sulfate is usually given after other tuberculosis medications have been tried without success. Capastat Sulfate may also be used for purposes not listed in this medication guide. Capastat Sulfate can harm your kidneys or damage the nerve that controls your hearing. These effects are increased if you already have kidney disease or hearing problems, or when you also use certain other medicines, including injected antibiotics. Before you use this medicine, tell your doctor about all your medical conditions and any medicines you are using. Learn more

Capastat sulfate Side Effects

Capastat Sulfate Side Effects

Note: This document contains side effect information about capreomycin. Some of the dosage forms listed on this page may not apply to the brand name Capastat Sulfate.

For the Consumer

Applies to capreomycin: injection powder for solution

Warning

Injection route (Powder for Solution)

Use capreomycin in patients with renal insufficiency or preexisting auditory impairment with great caution, and the risk of additional auditory impairment or renal injury should be weighed against the benefits to be derived from therapy. Simultaneous administration of other parenteral antituberculosis agents which have similar and sometimes irreversible toxic effects, particularly on auditory and renal function, is not recommended. Use with nonantituberculosis drugs having ototoxic or nephrotoxic potential should be undertaken only with great caution. The safety of capreomycin in pregnancy and in pediatric patients has not been established.

Along with its needed effects, capreomycin (the active ingredient contained in Capastat Sulfate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking capreomycin:

More common

  • Black, tarry stools
  • blood in the urine
  • change in the frequency of urination or amount of urine
  • chest pain
  • chills
  • cough
  • difficult breathing
  • dizziness
  • drowsiness
  • feeling of fullness in the ears
  • fever
  • increased thirst
  • loss of appetite
  • loss of balance
  • loss of hearing
  • nausea or vomiting
  • painful or difficult urination
  • ringing or buzzing in the ears
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the feet or lower legs
  • swollen glands
  • trouble with hearing
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Rare

  • Bleeding gums
  • pinpoint red spots on the skin

Incidence not known

  • Abdominal or stomach cramps
  • confusion
  • continuous ringing or buzzing or other unexplained noise in the ears
  • convulsions
  • decreased urine
  • dizziness or lightheadedness
  • dry mouth
  • feeling of constant movement of self or surroundings
  • irregular heartbeats
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle spasms (tetany) or twitching
  • numbness and tingling around the mouth, fingertips, or feet
  • sensation of spinning
  • tremor

Some side effects of capreomycin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Hives or welts, itching, or skin rash
  • pain, bleeding, or hard lump at the injection site
  • redness of the skin

For Healthcare Professionals

Applies to capreomycin: intramuscular powder for injection

General

The most commonly reported side effects included blood urea nitrogen (BUN) elevations above 20 mg/100 mL, subclinical hearing loss, and eosinophilia.

Renal

A fatal case of renal insufficiency and oliguria occurred in a patient with tuberculosis and portal cirrhosis treated with 1 g of this drug and aminosalicylic acid daily for 1 month. Toxic nephritis was reported, and autopsy showed subsiding acute tubular necrosis.

Very common (10% or more): BUN elevation above 20 mg/100 mL (up to 26%)

Common (1% to 10%): BUN elevation above 30 mg/100 mL

Frequency not reported: Acute tubular necrosis, depression of phenolsulfonphthalein (PSP) excretion, oliguria, renal insufficiency, toxic nephritis

Other

Very common (10% or more): Subclinical auditory loss (up to 11%)

Common (1% to 10%): Clinically apparent hearing loss

Frequency not reported: Death, febrile reaction, ototoxicity, tinnitus

Hematologic

Rare (0.01% to 0.1%): Thrombocytopenia

Frequency not reported: Eosinophilia, leukocytosis, leukopenia

Local

Frequency not reported: Excessive bleeding at injection site, injection site induration, injection site pain, sterile abscesses

Metabolic

Frequency not reported: Electrolyte disturbances, hypocalcemia, hypokalemia, hypomagnesemia

Hepatic

Frequency not reported: Abnormal liver function tests, decrease in bromsulphalein (BSP) excretion

Dermatologic

Frequency not reported: Maculopapular skin rashes, urticaria

Nervous system

Frequency not reported: Vertigo

Genitourinary

Frequency not reported: Abnormal urine sediment

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Capastat Sulfate (www.drugs.com/mtm/capastat-sulfate.html).