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Caffeine Anhydrous

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Caffeine anhydrous Prescription
Caffeine citrate is a central nervous system stimulant used to treat breathing problems in premature infants. Includes caffeine citrate side effects, interactions and indications.
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Caffeine Anhydrous Drug Information:

Caffeine is a central nervous system stimulant. It works by stimulating the brain. Caffeine is found naturally in foods and beverages such as coffee, tea, colas, energy and chocolate. Botanical sources of caffeine include kola nuts, guarana, and yerba mate. Caffeine is also available in prescription and non-prescription medications. Caffeine is used to restore mental alertness or wakefulness during fatigue or drowsiness. Caffeine is also found in some headache and migraine medications, in certain dietary supplements used for weight loss, and in many popular energy drinks. Learn more

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Caffeine Anhydrous Side Effects

In Summary

More frequently reported side effects include: necrotizing enterocolitis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to caffeine: oral solution, oral tablet

Other dosage forms:

  • intravenous solution

Along with its needed effects, caffeine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking caffeine:

More common

  • Feeding intolerance

Less common

  • Agitation
  • black, tarry stools
  • blood in the stools or urine
  • bruising
  • burning feeling or tenderness in the stomach
  • chills
  • coma
  • confusion
  • coughing or vomiting blood
  • decreased urine output
  • depression
  • dizziness
  • fainting
  • fast heartbeat
  • fever
  • headache
  • hostility
  • indigestion
  • irritability
  • lethargy
  • lightheadedness
  • muscle twitching
  • nausea
  • persistent bleeding
  • rapid, shallow breathing
  • rapid weight gain
  • rash
  • seizures
  • severe stomach pain
  • stomach upset
  • stupor
  • swelling of the face, ankles, or hands
  • trouble breathing
  • unusual tiredness or weakness
  • vomiting
  • vomiting of blood or material that looks like coffee grounds

Get emergency help immediately if any of the following symptoms of overdose occur while taking caffeine:

Symptoms of overdose

  • Irritability
  • nervousness
  • rapid heartbeat
  • trouble sleeping

Some side effects of caffeine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Rash

Less common

  • Dry skin

For Healthcare Professionals

Applies to caffeine: compounding powder, intravenous solution, oral gum, oral liquid, oral tablet, oral tablet dispersible, oral tablet extended release


Very common (10% or more): Constipation (up to 17.4%)

Common (1% to 10%): Necrotizing enterocolitis, gastritis, GI hemorrhage, gastroesophageal reflux, dilated bowel loops

Frequency not reported: Increased gastric aspirate, GI intolerance, vomiting, regurgitation


Long-term follow-up studies have not shown caffeine to adversely affect neurological development or growth parameters.


Common (1% to 10%): Hemorrhage, tachycardia

Uncommon (0.1% to 1%): Arrhythmia

Frequency not reported: Increased left ventricular output, increased stroke volume, hypertension


Common (1% to 10%): Rash, dry skin, skin breakdown


Common (1% to 10%): Disseminated intravascular coagulation, anemia

Frequency not reported: Decreased hemoglobin


Common (1% to 10%): Kidney failure


Common (1% to 10%): Acidosis, hyperglycemia

Frequency not reported: Hypoglycemia, temporary reduced weight gain, decreased thyroxine

Nervous system

Common (1% to 10%): Cerebral hemorrhage

Uncommon (0.1% to 1%): Convulsions/seizures

Frequency not reported: Irritability, restlessness, jitteriness, tremors, brain injury


Common (1% to 10%): Retinopathy of prematurity


Common (1% to 10%): Perinatal disorder (trace aspirates, feeding intolerances), injection site reaction, sepsis, accidental injury, abnormal healing, infusion site phlebitis and inflammation

Frequency not reported: Failure to thrive, deafness


Common (1% to 10%): Dyspnea, lung edema

Frequency not reported: Tachypnea


Rare (less than 0.1%): Hypersensitivity reaction


Frequency not reported: Increased urine flow rate, increased creatinine clearance, increased sodium and calcium excretion

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Caffeine Anhydrous (www.drugs.com/caffeine.html).