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Cabergoline

Generic Name: cabergoline (ca BER goe leen)
Brand Name: Dostinex
Physician reviewed cabergoline patient information - includes cabergoline description, dosage and directions.
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Drug Information:
Cabergoline is used to treat a hormone imbalance in which there is too much prolactin in the blood (also called hyperprolactinemia). Cabergoline may also be used for purposes not listed in this medication guide. You should not use cabergoline if you have uncontrolled high blood pressure, a heart valve disorder, or a condition called fibrosis (growth of excess tissue in or around internal organs). You should not use cabergoline if you are allergic to any type of ergot medicine. You should not use cabergoline if you are allergic to it, or if you have: Learn more

Cabergoline Side Effects

Cabergoline Side Effects

For the Consumer

Applies to cabergoline: oral tablet

Along with its needed effects, cabergoline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cabergoline:

Less common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chills
  • cold sweats
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from lying or sitting position
  • fast, irregular, pounding, or racing heartbeat or pulse
  • general feeling of discomfort or illness
  • rapid weight gain
  • swelling around the eyes
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss

Incidence not known

  • Chest pain or tightness
  • continuing loss of appetite
  • continuing or severe abdominal or stomach pain
  • continuing or severe nausea and vomiting
  • cough
  • decreased ability to exercise
  • fever
  • increased frequency of urination
  • loss of appetite
  • lower abdominal or stomach pain
  • lower back pain
  • nausea
  • shortness of breath
  • trouble with breathing
  • vomiting
  • weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking cabergoline:

Symptoms of overdose

  • Fainting
  • seeing, hearing, or feeling things that are not there
  • stuffy nose

Some side effects of cabergoline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty having a bowel movement (stool)
  • dizziness
  • excess air or gas in the stomach or intestines
  • full feeling
  • headache
  • lack or loss of strength
  • passing gas

Less common

  • Abdominal or stomach pain
  • acid or sour stomach
  • anxiety
  • belching
  • blemishes on the skin
  • breast pain
  • burning, itching, or stinging of the skin
  • changes in vision
  • cramps
  • depression
  • diarrhea
  • difficulty with moving
  • dry mouth or toothache
  • feeling of constant movement of self or surroundings
  • feeling of warmth
  • gas
  • heartburn
  • heavy bleeding
  • indigestion
  • itching skin
  • joint pain
  • muscle aches and pains
  • muscle stiffness
  • pimples
  • redness of the face, neck, arms, and occasionally, upper chest
  • runny nose
  • sensation of spinning
  • shivering
  • sleeplessness
  • sleepiness or unusual drowsiness
  • sneezing
  • sore throat
  • stomach discomfort or upset
  • sudden sweating
  • trouble with sleeping
  • unable to sleep
  • weight loss

Rare

  • Bloody nose
  • difficulty in concentrating
  • increased in sexual ability, desire, drive, or performance
  • increased interest in sexual intercourse

Incidence not known

  • Attack, assault, or force
  • feeling that others are watching you or controlling your behavior
  • feeling that others can hear your thoughts
  • hair loss or thinning of the hair
  • pathological gambling
  • severe mood or mental changes
  • unusual behavior

For Healthcare Professionals

Applies to cabergoline: oral tablet

Gastrointestinal

Very common (10% or more): Nausea (up to 29%)

Common (1% to 10%): Constipation, dyspepsia, gastritis, vomiting, abdominal pain, dyspepsia, dry mouth, diarrhea, flatulence, throat irritation, toothache

Nervous system

Very common (10% or more): Headache (up to 26%), dizziness (up to 17%)

Common (1% to 10%): Dizziness/vertigo, dyskinesia, paresthesia, somnolence

Uncommon (0.1% to 1%): Hyperkinesia

Frequency not reported: Sudden sleep onset, syncope, tremor

Other

Common (1% to 10%): Asthenia

Uncommon (0.1% to 1%): Fatigue, malaise

Psychiatric

Common (1% to 10%): Hallucinations sleep disturbance, increased libido, confusion, depression, anxiety, insomnia, nervousness

Uncommon (0.1% to 1%): Delusions, psychotic disorder

Frequency not reported: Aggression, hypersexuality, pathological gambling

Cardiovascular

Very common (10% or more): Peripheral edema

Common (1% to 10%): Angina (with concomitant levodopa use), postural hypotension, hot flashes, cardiac valvulopathy, hypotension, dependent edema, palpitation

Uncommon (0.1% to 1%): Erythromelalgia

Rare (less than 0.1%): Syncope, heart failure

Frequency not reported: Constrictive pericarditis, digital vasospasm

Postmarketing reports: Cardiac valvulopathy, pericarditis, pericardial effusion

Reports of cardiac valvulopathy have generally been received in patients on higher doses (greater than 2 mg/day); however, there have been cases in patients receiving lower doses for the treatment of hyperprolactinemic disorders. In a multi-country, retrospective cohort study, record review looking for an association between the new use of dopamine agonists (including this drug; n=27,812) and cardiac valvular regurgitation (CVR), other fibrosis, and other cardiopulmonary events found an increased risk of CVR among patients with Parkinson's disease when compared to non-ergot derived dopamine agonists and levodopa. Analysis in patients with hyperprolactinemia treated with this drug (n=8386) found that compared to non-users, exposed persons did not have an elevated risk of CVR. These findings are consistent with other published studies.

Musculoskeletal

Frequency not reported: Leg cramps

Dermatologic

Uncommon (0.1% to 1%): Rash, acne, pruritus

Frequency not reported: Alopecia

Respiratory

Common (1% to 10%): Dyspnea

Uncommon (0.1% to 1%): Pleural effusion, pulmonary fibrosis, rhinitis

Very rare (less than 0.01%): Fibrosis (including pleural fibrosis)

Frequency not reported: Respiratory disorder, respiratory failure, pleuritic, chest pain

Ocular

Uncommon (0.1% to 1%): Periorbital edema, abnormal vision

Endocrine

Common (1% to 10%): Breast pain

Uncommon (0.1% to 1%): Dysmenorrhea

General

Adverse effects are generally dose related. At lower doses, the more commonly reported adverse reactions included nausea, headache, dizziness/vertigo, abdominal pain/dyspepsia/gastritis, asthenia/fatigue; at higher doses, additional events of valvulopathy, dyspnea, dyskinesia, orthostatic hypotension, hallucination, and constipation have been commonly reported.

Hepatic

Uncommon (0.1% to 1%): Hepatic function abnormalities

Postmarketing reports: Liver function test abnormal

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity reaction

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Cabergoline (www.drugs.com/mtm/cabergoline.html).