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Bystolic Prescription
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Generic Name: nebivolol (ne BIV oh lol)
Brand Names: Bystolic
Bystolic is a beta-blocker and is used to treat hypertension (high blood pressure). Learn about side effects, interactions and indications.
Generic Name: nebivolol (ne BIV oh lol)
Brand Names: Bystolic
Bystolic is a beta-blocker and is used to treat hypertension (high blood pressure). Learn about side effects, interactions and indications.
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30 tablets of Bystolic 40 mg
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Offers Claimed: 192

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Bystolic Drug Information:

Bystolic (nebivolol) belongs to a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Bystolic is used to treat hypertension (high blood pressure). Lowering blood pressure may lower your risk of a stroke or heart attack. Bystolic may also be used for other purposes not listed in this medication guide. Do not skip doses or stop taking Bystolic without first talking to your doctor. Stopping suddenly may make your condition worse or cause other serious heart problems such as severe chest pain or heart attack. You may need to use less and less before you stop the medication completely. If you need surgery, tell the surgeon ahead of time that you are using Bystolic. Learn more

Bystolic Medicare Coverage

Bystolic Medicare Overview

Does Medicare cover Bystolic?


100% of Medicare Part D and Medicare Advantage plans cover this drug.
How much is my Bystolic co-pay with Medicare?

It depends. Which coverage stage are you in? Click on a tab below…


FREE – $30

In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.

Ways to Save on Bystolic

Here are some ways that may lower the cost of your bystolic prescription.

  • Instead of Medicare, Use a USA Rx Coupon

    If your Medicare co-pay is higher, you can save money by using a USARx coupon instead.

Bystolic Side Effects

Note: This document contains side effect information about nebivolol. Some of the dosage forms listed on this page may not apply to the brand name Bystolic.

In Summary

More frequent side effects include: fatigue. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to nebivolol: oral tablet

Along with its needed effects, nebivolol (the active ingredient contained in Bystolic) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking nebivolol:

Less common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • chest pain or discomfort
  • difficult or labored breathing
  • lightheadedness, dizziness, or fainting
  • rapid weight gain
  • shortness of breath
  • slow or irregular heartbeat
  • tightness in the chest
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking nebivolol:

Symptoms of overdose

  • Absence of or decrease in body movement
  • anxiety
  • blue lips, fingernails, or skin
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • cough
  • decreased urine output
  • depression
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • extreme fatigue
  • fast heartbeat
  • headache
  • increased hunger
  • increased sweating
  • increased thirst
  • irregular, fast or slow, or shallow breathing
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • nervousness
  • nightmares
  • noisy breathing
  • numbness in the hands, feet, or lips
  • seizures
  • shakiness
  • slurred speech
  • troubled breathing
  • vomiting
  • weight gain

Some side effects of nebivolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Mild headache

Less common

  • Diarrhea
  • rash
  • sleeplessness
  • trouble sleeping
  • unable to sleep

For Healthcare Professionals

Applies to nebivolol: oral tablet


The more frequently reported side effects in patients treated for hypertension were headache, dizziness, and fatigue; additionally, bradycardia was frequently reported in patients treated for chronic heart failure.


Very common (10% or more): Bradycardia (up to 11%)

Common (1% to 10%): Cardiac failure aggravation, edema, postural hypotension, first degree atrioventricular (AV) block, atrial fibrillation, hypertension, angina pectoris, chest pain

Uncommon (0.1% to 1%): Heart failure, slowed AV conduction, AV block (both second and third degree), hypotension, increased intermittent claudication, edema of the lower limbs,

Postmarketing reports: Raynaud's phenomenon, myocardial infarction, peripheral ischemia

Bradycardia was a dose-related effect in hypertensive patients. Bradycardia occurred more frequently in chronic heart failure patients (11%) than hypertensive patients (1%) at doses of 20 to 40 mg.

Aggravation of cardiac failure occurred in 19% of patients with chronic heart failure compared to 21.3% of placebo-treated patients in the SENIORS (Study on the Effects of Nebivolol Interventions on Outcomes and Rehospitalizations in Seniors with heart failure; n = 2128; median age = 75.2 years). Heart failure occurred in 0.1% to 1% of hypertensive patients.

Nervous system

Very common (10% or more): Dizziness (up to 11%)

Common (1% to 10%): Headache, paresthesia, somnolence, hypoesthesia

Uncommon (0.1% to 1%): Vertigo

Very rare (less than 0.01%): Syncope


Common (1% to 10%): Dyspnea, exacerbated dyspnea, common cold, coughing, bronchitis, pharyngitis

Uncommon (0.1% to 1%): Bronchospasm

Postmarketing reports: Acute pulmonary edema


Common (1% to 10%): Increased sweating

Uncommon (0.1% to 1%): Pruritus, erythematous rash

Very rare (less than 0.01%): Psoriasis aggravated

Frequency not reported: Angioneurotic edema, urticaria

Postmarketing reports: Rash, skin disorders


Common (1% to 10%): Myalgia, arthrosis, back pain


Common (1% to 10%): Constipation, diarrhea, nausea

Uncommon (0.1% to 1%): Dyspepsia, flatulence, vomiting

Frequency not reported: Abdominal pain


Common (1% to 10%): Tiredness, drug intolerance, pain, injury, fatigue

Frequency not reported: Asthenia


Common (1% to 10%): Nervousness

Uncommon (0.1% to 1%): Nightmares, depression, insomnia, anxiety


Uncommon (0.1% to 1%): Impotence


Uncommon (0.1% to 1%): Impaired vision


Frequency not reported: Decreased platelet count

Postmarketing reports: Thrombocytopenia


Frequency not reported: Increased BUN

Postmarketing reports: Acute renal failure


Frequency not reported: Hypercholesterolemia, hyperuricemia, increased uric acid, increased triglycerides, decreased HDL cholesterol


Postmarketing reports: Abnormal hepatic function (e.g., increased AST, ALT, and bilirubin)


Postmarketing reports: Hypersensitivity (e.g., allergic vasculitis, angioedema, urticaria)

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Bystolic (www.drugs.com/bystolic.html).