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Buphenyl

Generic Name: sodium phenylbutyrate (SOE dee um FEN il BUE ti rate)
Brand Name: Buphenyl
Physician reviewed Buphenyl patient information - includes Buphenyl description, dosage and directions.
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Drug Information:
Buphenyl is converted to a substance in the body that helps the kidneys eliminate waste substances from the body. These waste substances can produce ammonia, which is toxic if it builds up in your blood. Buphenyl is used to treat Urea cycle disorders in people who lack certain liver enzymes needed to properly eliminate waste substances from the body. Buphenyl helps prevent a build-up of ammonia in the blood. Buphenyl may also be used for other purposes not listed in this medication guide. Seek emergency medical attention if you notice any signs of ammonia build-up, including mood or behavior changes, memory loss, thinking problems, muscle twitching, back and forth movement of the eyes, vomiting, increasing weakness, slurred speech, seizure (convulsions), and fainting. Learn more

Buphenyl Side Effects

Buphenyl Side Effects

Note: This document contains side effect information about sodium phenylbutyrate. Some of the dosage forms listed on this page may not apply to the brand name Buphenyl.

For the Consumer

Applies to sodium phenylbutyrate: oral powder, oral tablet

Along with its needed effects, sodium phenylbutyrate (the active ingredient contained in Buphenyl) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sodium phenylbutyrate:

More common

  • Change in the frequency of breathing
  • lack of or irregular menstruation
  • lower back, side, or stomach pain
  • mood or mental changes
  • muscle pain or twitching
  • nausea or vomiting
  • nervousness or restlessness
  • swelling of the feet or lower legs
  • unpleasant taste
  • unusual tiredness or weakness

Less common

  • Chills
  • fever
  • joint pain
  • sore throat
  • unusual bleeding or bruising

Rare

  • Convulsions (seizures)
  • dizziness
  • dryness of the mouth
  • fast, slow, or irregular heartbeat
  • increased blood pressure
  • increased thirst
  • irritability
  • muscle cramps
  • rectal bleeding
  • swelling of the face
  • unusual weight gain
  • weak pulse

Some side effects of sodium phenylbutyrate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Changes in taste
  • decreased appetite
  • strong body odor

Rare

  • Abdominal or stomach pain
  • constipation
  • fainting
  • headache
  • mental depression
  • skin rash

For Healthcare Professionals

Applies to sodium phenylbutyrate: oral powder for reconstitution, oral tablet

General

Causality of adverse effects is sometimes difficult to determine because they may result from either the underlying disease, the patient's restricted diet, intercurrent illness, or the drug itself.

Endocrine

Very common (10% or more): Amenorrhea/menstrual dysfunction (23%)

Metabolic

Very common (10% or more): Acidosis (14%), hypoalbuminemia (11%)

Common (1% to 10%): Alkalosis, decreased appetite, hyperchloremia, hypophosphatemia, decreased total protein, hyperuricemia, hyperphosphatemia, hypernatremia, hypokalemia, increased weight

Cardiovascular

Common (1% to 10%): Edema

Uncommon (0.1% to 1%): Arrhythmia

Dermatologic

Common (1% to 10%): Rash, body odor

Gastrointestinal

Common (1% to 10%): Abdominal pain, nausea, vomiting, constipation, dysgeusia

Uncommon (0.1% to 1%): Pancreatitis, rectal bleeding/hemorrhage, peptic ulcer, gastritis

Hematologic

Common (1% to 10%): Anemia, leukopenia, leukocytosis, thrombocytopenia, thrombocytosis

Uncommon (0.1% to 1%): Aplastic anemia, ecchymosis

Hepatic

Common (1% to 10%): Increased alkaline phosphatase, increased liver transaminases, hyperbilirubinemia

Nervous system

Common (1% to 10%): Syncope, headache, bad taste/taste aversion

Frequency not reported: Somnolence, fatigue, lightheadedness, hypoacusis, disorientation, impaired memory, exacerbation of preexisting neuropathy

Psychiatric

Common (1% to 10%): Depression, irritability

Renal

Common (1% to 10%): Renal tubular acidosis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Buphenyl (www.drugs.com/mtm/buphenyl.html).