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Bumetanide Prescription
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Generic Name: bumetanide (oral/injection) (byoo MET a nide)
Brand Name: Bumex
Physician reviewed bumetanide (oral/injection) (oral/injection) patient information - includes bumetanide (oral/injection) description, dosage and directions. Average Savings for bumetanide (generic): 47.73%
Generic Name: bumetanide (oral/injection) (byoo MET a nide)
Brand Name: Bumex
Physician reviewed bumetanide (oral/injection) (oral/injection) patient information - includes bumetanide (oral/injection) description, dosage and directions. Average Savings for bumetanide (generic): 47.73%
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30 tablets of Bumetanide 40 mg
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Offers Claimed: 110

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Bumetanide Drug Information:

Bumetanide is diuretic that is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome. Bumetanide may also be used for purposes not listed in this medication guide. You should not use bumetanide if you are unable to urinate, if you have severe kidney or liver disease, if you are severely dehydrated, or if you have an electrolyte imbalance (low potassium or magnesium). You should not use bumetanide if you are allergic to it, or if you have: Learn more

Bumetanide Medicare Coverage

Bumetanide Medicare Overview

Does Medicare cover Bumetanide?


100% of Medicare Part D and Medicare Advantage plans cover this drug.
How much is my Bumetanide co-pay with Medicare?

It depends. Which coverage stage are you in? Click on a tab below…


$1 – $26

In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.

Ways to Save on Bumetanide

Here are some ways that may lower the cost of your bumetanide prescription.

  • Instead of Medicare, Use a USA Rx Coupon

    If your Medicare co-pay is higher, you can save money by using a USARx coupon instead.

Bumetanide Side Effects

In Summary

Commonly reported side effects of bumetanide include: hypokalemia and hyperuricemia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to bumetanide: oral tablet

Other dosage forms:

  • injection solution

Oral route (Tablet)

Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be adjusted to the individual patient's needs.

Along with its needed effects, bumetanide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking bumetanide:

More common

  • Abdominal pain
  • blurred vision
  • confusion
  • decreased urine output
  • dizziness
  • drowsiness
  • dry mouth
  • fast or irregular heartbeat
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • irritability
  • joint pain, stiffness, or swelling
  • loss of appetite
  • loss of mental alertness
  • lower back, side, or stomach pain
  • mood or mental changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • sweating
  • swelling of face, hands, feet, ankles, or lower legs
  • troubled breathing
  • unexplained weight loss
  • unusual tiredness or weakness
  • weak pulse


  • Agitation
  • back pain
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • chest pain
  • convulsions (seizures)
  • deep or fast breathing with dizziness
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • fever
  • hallucinations
  • hives
  • increase in heart rate
  • increased blood pressure
  • numbness of feet, hands, and around the mouth
  • pinpoint red spots on the skin
  • rapid breathing
  • stiff neck
  • sunken eyes
  • trembling, jerking of hands
  • unusual bleeding or bruising
  • weight gain
  • wrinkled skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking bumetanide:

Symptoms of overdose

  • Difficulty breathing
  • pain in chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • unusual drowsiness, dullness, or feeling of sluggishness
  • vision changes

Some side effects of bumetanide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


  • Decreased interest in sexual intercourse
  • diarrhea
  • difficulty with moving
  • ear discomfort
  • feeling of constant movement of self or surroundings
  • inability to have or keep an erection
  • itching skin
  • loss in sexual ability, desire, drive, or performance
  • muscle or bone pain
  • muscle stiffness
  • nipple tenderness
  • pain, swelling, or redness in joints
  • rash
  • sensation of spinning
  • shorter than usual time to ejaculation of semen
  • trouble with hearing
  • upset stomach

For Healthcare Professionals

Applies to bumetanide: compounding powder, injectable solution, oral tablet


Metabolic side effects associated with bumetanide, as with other loop diuretics, occur in 7% to 20% of patients, and include hyponatremia, hypokalemia, hypochloremia, and hyperuricemia. These side effects may be more likely in patients with renal insufficiency. Glucose intolerance is reported in up to 14% of elderly patients. Hypokalemia may lead to increased renal tubular bicarbonate reabsorption, resulting in metabolic alkalosis.

Besides acting on the loop of Henle, bumetanide also inhibits phosphate reabsorption in the proximal tubule, resulting in phosphaturia. Since phosphorous is abundant in most diets, bumetanide-induced phosphaturia may not be significant except in malnourished patients, patients on life support, and patients with significant muscle weakness.

Calcium balance appears to remain neutral during treatment with a loop diuretic (i.e., furosemide, bumetanide). Although loop diuretics cause an increase in renal calcium excretion, this appears to be compensated for by a parathyroid-dependent increase in 1,25-dihydroxyvitamin D levels, which increases intestinal calcium absorption. Bone metabolism does not appear to be significantly affected by loop diuretics.


Musculoskeletal side effects have included muscle cramps in 1.1% and weakness in 0.2% of patients.


Renal insufficiency, manifested as a rise in serum creatinine and BUN, may occur in up to 7% of patients. It is usually due to extracellular fluid volume depletion and is readily reversible.


Cardiovascular side effects include hypotension in less than 2% of patients. Patients with a history of cardiac arrhythmias should be monitored closely because of the risk of hypokalemia.


Gastrointestinal side effects were reported in less than 2% of patients and included nausea, vomiting, loose stools, and constipation. There have been rare reports of hyperamylasemia and pancreatitis associated with bumetanide use.

Nervous system

Nervous system side effects, such as headache, dizziness, deafness, tinnitus, vertigo, and decreased hearing, are reported in less than 2% of patients. Encephalopathy after bumetanide administration is reported in patients with severe liver disease.


Severe hypersensitivity reactions such as Stevens-Johnson syndrome and recurrent urticaria have been reported in rare cases.

Hypersensitivity reactions are rare. Rash is reported in less than 1% of treated patients. Because cross-reactivity with furosemide is rare, bumetanide can be substituted at about a 1:40 dose ratio of bumetanide to furosemide in patients allergic to furosemide.


Dermatologic side effects have included pseudoporphyria, Stevens-Johnson syndrome, and toxic epidermal necrolysis.


Hematologic side effects are extremely rare. Cases of thrombocytopenia, mild anemia, and leukopenia have been reported.

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Bumetanide (www.drugs.com/mtm/bumetanide-oral-injection.html).