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In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.
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Bumetanide is diuretic that is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome.
Bumetanide may also be used for purposes not listed in this medication guide.
You should not use bumetanide if you are unable to urinate, if you have severe kidney or liver disease, if you are severely dehydrated, or if you have an electrolyte imbalance (low potassium or magnesium).
You should not use bumetanide if you are allergic to it, or if you have:
severe kidney disease or are unable to urinate;
severe liver disease or cirrhosis;
severe dehydration; or
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
Tell your doctor if you have ever had:
a heart rhythm disorder;
liver disease;
kidney disease (or if you are on dialysis);
gout;
an allergy to sulfa drugs; or
if you are on a low-salt diet.
Tell your doctor if you are pregnant or breast-feeding.
Bumetanide is not approved for use by anyone younger than 18 years old.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Bumetanide injection is injected into a muscle, or given as an infusion into a vein. A healthcare provider will give you this injection if you are unable to take the medicine by mouth.
Bumetanide will make you urinate more often and you may get dehydrated easily. Follow your doctor's instructions about taking potassium supplements or getting enough salt and potassium in your diet.
Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking bumetanide. This can lead to very low blood pressure, a serious electrolyte imbalance, or kidney failure.
You will need frequent medical tests.
Store at room temperature away from heat, moisture, and light.
Bumetanide is sometimes used only once, so you may not be on a dosing schedule. If you are on a dosing schedule, take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include extreme dizziness or weakness, confusion, loss of appetite, stomach cramps, and vomiting.
Avoid becoming dehydrated. Follow your doctor's instructions about the type and amount of liquids you should drink while you are taking bumetanide.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
hearing problems;
confusion, hallucinations, problems with thought or memory;
trouble speaking or understanding what is said to you;
unusual weakness;
twitching, or a seizure;
weak or shallow breathing;
easy bruising, unusual bleeding, purple or red spots under your skin;
low magnesium--dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling;
low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or
dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.
Common side effects may include:
muscle cramps;
dizziness;
low blood presure;
nausea; or
headache.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Bumetanide can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, or pain or arthritis (including aspirin, Tylenol, Advil, and Aleve).
Tell your doctor about all your other medicines, especially:
lithium;
digoxin;
probenecid;
indomethacin;
blood pressure medication; or
any other diuretic.
This list is not complete. Other drugs may affect bumetanide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Bumetanide (www.drugs.com/mtm/bumetanide-oral-injection.html).
Commonly reported side effects of bumetanide include: hypokalemia and hyperuricemia. See below for a comprehensive list of adverse effects.
Applies to bumetanide: oral tablet
Other dosage forms:
Oral route (Tablet)
Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required, and dose and dosage schedule have to be adjusted to the individual patient's needs.
Along with its needed effects, bumetanide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking bumetanide:
More common
Rare
Get emergency help immediately if any of the following symptoms of overdose occur while taking bumetanide:
Symptoms of overdose
Some side effects of bumetanide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Rare
Applies to bumetanide: compounding powder, injectable solution, oral tablet
Metabolic side effects associated with bumetanide, as with other loop diuretics, occur in 7% to 20% of patients, and include hyponatremia, hypokalemia, hypochloremia, and hyperuricemia. These side effects may be more likely in patients with renal insufficiency. Glucose intolerance is reported in up to 14% of elderly patients. Hypokalemia may lead to increased renal tubular bicarbonate reabsorption, resulting in metabolic alkalosis.
Besides acting on the loop of Henle, bumetanide also inhibits phosphate reabsorption in the proximal tubule, resulting in phosphaturia. Since phosphorous is abundant in most diets, bumetanide-induced phosphaturia may not be significant except in malnourished patients, patients on life support, and patients with significant muscle weakness.
Calcium balance appears to remain neutral during treatment with a loop diuretic (i.e., furosemide, bumetanide). Although loop diuretics cause an increase in renal calcium excretion, this appears to be compensated for by a parathyroid-dependent increase in 1,25-dihydroxyvitamin D levels, which increases intestinal calcium absorption. Bone metabolism does not appear to be significantly affected by loop diuretics.
Musculoskeletal side effects have included muscle cramps in 1.1% and weakness in 0.2% of patients.
Renal insufficiency, manifested as a rise in serum creatinine and BUN, may occur in up to 7% of patients. It is usually due to extracellular fluid volume depletion and is readily reversible.
Cardiovascular side effects include hypotension in less than 2% of patients. Patients with a history of cardiac arrhythmias should be monitored closely because of the risk of hypokalemia.
Gastrointestinal side effects were reported in less than 2% of patients and included nausea, vomiting, loose stools, and constipation. There have been rare reports of hyperamylasemia and pancreatitis associated with bumetanide use.
Nervous system side effects, such as headache, dizziness, deafness, tinnitus, vertigo, and decreased hearing, are reported in less than 2% of patients. Encephalopathy after bumetanide administration is reported in patients with severe liver disease.
Severe hypersensitivity reactions such as Stevens-Johnson syndrome and recurrent urticaria have been reported in rare cases.
Hypersensitivity reactions are rare. Rash is reported in less than 1% of treated patients. Because cross-reactivity with furosemide is rare, bumetanide can be substituted at about a 1:40 dose ratio of bumetanide to furosemide in patients allergic to furosemide.
Dermatologic side effects have included pseudoporphyria, Stevens-Johnson syndrome, and toxic epidermal necrolysis.
Hematologic side effects are extremely rare. Cases of thrombocytopenia, mild anemia, and leukopenia have been reported.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Bumetanide (www.drugs.com/mtm/bumetanide-oral-injection.html).
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