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Brovana

Generic Name: arformoterol inhalation (ar for MOE ter ole)
Brand Names: Brovana
Brovana (arformoterol) prevents bronchoconstriction in people with chronic obstructive pulmonary disease (COPD). Includes Brovana side effects, interactions and indications.
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Drug Information:
Brovana (arformoterol) is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Brovana inhalation solution is used to prevent bronchoconstriction in people with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Brovana will not treat a bronchospasm attack that has already begun. Brovana is for use only in people with chronic obstructive pulmonary disease (COPD) and should not be used to treat asthma. Brovana is not a rescue medicine. It will not work fast enough to treat a bronchospasm attack. Learn more

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Brovana Side Effects

Note: This document contains side effect information about arformoterol. Some of the dosage forms listed on this page may not apply to the brand name Brovana.

For the Consumer

Applies to arformoterol: inhalation solution

Warning

Inhalation route (Solution)

Long-acting beta(2)-adrenergic agonists increase the risk of asthma-related deaths. This finding was obtained from data from a large placebo-controlled United States study that showed an increase in asthma-related deaths in patients receiving salmeterol (another long-acting beta(2)-adrenergic agonist). Safety and efficacy of arformoterol in patients with asthma have not been established. All LABA, including arformoterol, are contraindicated in patients with asthma without use of a long-term asthma control medication.

Along with its needed effects, arformoterol (the active ingredient contained in Brovana) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking arformoterol:

More common

  • Back pain
  • chest pain
  • diarrhea
  • pain

Less common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • chills
  • cough
  • difficult or labored breathing
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • leg cramps
  • loss of appetite
  • muscle aches and pains
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • rapid weight gain
  • rash
  • shivering
  • shortness of breath
  • sore throat
  • stuffy or runny nose
  • sweating
  • tightness of the chest
  • tingling of the hands or feet
  • trouble with sleeping
  • troubled breathing
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting
  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking arformoterol:

Symptoms of overdose

  • Arm, back, or jaw pain
  • blurred vision
  • chest discomfort
  • chest tightness or heaviness
  • confusion
  • convulsions
  • decreased urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fast, pounding, or irregular heartbeat or pulse
  • increased thirst
  • mood changes
  • muscle pain or cramps
  • muscle tremors
  • nervousness
  • no blood pressure or pulse
  • numbness or tingling in the hands, feet, or lips
  • pounding in the ears
  • rapid, deep breathing
  • restlessness
  • slow heartbeat
  • stomach cramps
  • stopping of the heart
  • tremor
  • unconsciousness

For Healthcare Professionals

Applies to arformoterol: inhalation solution

Respiratory

Two double-blind, placebo-controlled clinical trials showed a decreased or comparable incidence of COPD exacerbations when compared to placebo. COPD exacerbations occurred at a rate of 12.1% for those patients receiving the drug and 15.1% for those patients receiving placebo.

Common (1% to 10%): Dyspnea, sinusitis, flu syndrome, pulmonary and chest congestion

Frequency not reported (Less than 2%): Respiratory disorder, voice alteration

Cardiovascular

Common (1% to 10%): Chest pain, peripheral edema

Frequency not reported (Less than 2%): Arteriosclerosis, atrial flutter, AV block, congestive heart failure, heart block, myocardial infarct, QT interval prolongation, supraventricular tachycardia, inverted T-wave

Two double-blind, placebo-controlled clinical trials showed a decreased or comparable incidence of cardiovascular events. Frequency of all cardiovascular events was 6.9% in those using the drug and 13.3% in the placebo group. No frequently occurring, defined as 1% or greater than placebo, cardiovascular events were associated.

Dermatologic

Common (1% to 10%): Rash

Frequency not reported (Less than 2%): Dry skin, herpes simplex, herpes zoster, skin discoloration, skin hypertrophy

Gastrointestinal

Common (1% to 10%): Diarrhea

Frequency not reported (Less than 2%): Constipation, gastritis, melena, oral moniliasis, periodontal abscess, rectal hemorrhage

Musculoskeletal

Common (1% to 10%): Back pain, leg cramps

Frequency not reported (Less than 2%): Neck rigidity, pelvic pain, arthralgia, arthritis, rheumatoid arthritis, bone disorder, tendinous contracture

Hematologic

Frequency not reported (Less than 2%): Retroperitoneal hemorrhage

Hypersensitivity

Frequency not reported (Less than 2%): Allergic reaction

Local

Frequency not reported (Less than 2%): Injection site pain

Metabolic

Frequency not reported (Less than 2%): Dehydration, edema, glucose tolerance decreased, gout, hyperglycemia, hyperlipidemia, hypoglycemia, hypokalemia

Nervous system

Frequency not reported (Less than 2%): Agitation, cerebral infarct, circumoral paresthesia, hypokinesia, somnolence, tremor, paralysis

Ocular

Frequency not reported (Less than 2%): Abnormal vision, glaucoma

Oncologic

Frequency not reported (Less than 2%): Neoplasm, carcinoma of the lung, breast neoplasm

Other

Common (1% to 10%): Pain

Frequency not reported (Less than 2%): Digitalis intoxication, abscess, fever, hernia

Genitourinary

Frequency not reported (Less than 2%): Calcium crystalluria, cystitis, glycosuria, hematuria, kidney calculus, nocturia, PSA increase, pyuria, urinary tract disorder, urine abnormality

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Brovana (www.drugs.com/brovana.html).