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Blincyto

Generic Name: blinatumomab (BLIN a TOOM oh mab)
Brand Name: Blincyto
Physician reviewed Blincyto patient information - includes Blincyto description, dosage and directions.
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Drug Information:
Blincyto is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Blincyto is used to treat a certain type of acute lymphoblastic leukemia in adults and children. Blincyto is given after other cancer treatments have been tried without success. Blincyto was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to this medicine, but further studies are needed. Blincyto may also be used for purposes not listed in this medication guide. Learn more

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Blincyto Side Effects

Note: This document contains side effect information about blinatumomab. Some of the dosage forms listed on this page may not apply to the brand name Blincyto.

In Summary

Common side effects of Blincyto include: encephalopathy, seizure disorder, febrile neutropenia, opportunistic infection, balance impairment, confusion, cytokine release syndrome, disorientation, headache, impaired consciousness, tremor, fever, hypotension, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, nausea, neutropenia, speech disturbance, and bacteremia. Other side effects include: pneumonia, sepsis, tumor lysis syndrome, and increased serum bilirubin. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to blinatumomab: intravenous powder for solution

Warning

Intravenous route (Powder for Solution)

Cytokine Release Syndrome (CRS), which may be life-threatening or fatal, occurred in patients receiving blinatumomab. Neurological toxicities, which may be severe, life-threatening, or fatal, occurred in patients receiving blinatumomab. Interrupt or discontinue blinatumomab as recommended.

Along with its needed effects, blinatumomab (the active ingredient contained in Blincyto) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking blinatumomab:

More common

  • Agitation
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision
  • chest pain
  • chills
  • confusion
  • cough
  • dizziness
  • fever
  • headache
  • hoarseness
  • irritability
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • rapid, shallow breathing
  • seeing, hearing, or feeling things that are not there
  • seizures
  • sore throat
  • stiff neck
  • tightness in the chest
  • tingling of the hands or feet
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting

Incidence not known

  • Cloudy urine
  • darkened urine
  • discouragement
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extremely high fever or body temperature
  • eye pain
  • feeling sad or empty
  • general feeling of illness
  • irritability
  • lack or loss of strength
  • loss of interest or pleasure
  • mood or mental changes
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • persistent bleeding or oozing from puncture sites, mouth, or nose
  • pounding in the ears
  • problems with speech or speaking
  • rash
  • slow or fast heartbeat
  • stomach pain
  • sweating
  • swelling of the hands, ankles, feet, or lower legs
  • trouble sleeping
  • ulcers, sores, or white spots in the mouth
  • yellow eyes or skin

Some side effects of blinatumomab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bone, joint, or muscle pain
  • change in urination
  • decreased appetite
  • diarrhea
  • difficulty having a bowel movement
  • dry mouth
  • increased hunger or thirst
  • irregular heartbeat
  • muscle pain or cramps
  • pain in the arms or legs
  • shakiness in the legs, arms, hands, or feet

For Healthcare Professionals

Applies to blinatumomab: intravenous powder for injection

Cardiovascular

Very common (10% or more): Hypotension (up to 11%)

Common (1% to 10%): Hypertension, tachycardia

Dermatologic

Very common (10% or more): Rash (e.g., erythema, rash, erythematous rash, generalized rash, macular rash, maculopapular rash, papular rash, vesicular rash)

Gastrointestinal

Very common (10% or more): Nausea (up to 25%), constipation (up to 20%), diarrhea (e.g., colitis, diarrhea, enteritis, and neutropenic colitis) (up to 20%), abdominal pain (up to 15%), vomiting (up to 13%)

Hematologic

Very common (10% or more): Febrile neutropenia (up to 25%), anemia (up to 18%), neutropenia (up to 16%), thrombocytopenia (up to 11%)

Common (1% to 10%): Leukopenia, leukocytosis, lymphopenia

Uncommon (0.1% to 1%): Capillary leak syndrome

Hypersensitivity

Common (1% to 10%): Hypersensitivity

Immunologic

Very common (10% or more): Cytokine release syndrome (up to 11%), various pathogen infections (44%), bacterial infections (19%), fungal infections (15%), viral infections (13%), increased weight (up to 11%)

Common (1% to 10%): Pneumonia, sepsis, decreased immunoglobulins, increased blood bilirubin, increased gammaglutamyl-transferase, increased liver enzymes

Local

Common (1% to 10%): Cytokine storm

Metabolic

Very common (10% or more): Hypokalemia (up to 23%), hypomagnesemia (up to 12%), hyperglycemia (up to 11%), decreased appetite (up to 10%)

Common (1% to 10%): Hypophosphatemia, tumor lysis syndrome, hypoalbuminemia

Musculoskeletal

Very common (10% or more): Back pain (14%), pain in extremity (up to 12%), bone pain (11%), arthralgia (10%)

Nervous system

Very common (10% or more): Headache (up to 36%), tremor (e.g., resting tremor and tremor) (up to 20%), dizziness (up to 14%)

Common (1% to 10%): Encephalopathy, paresthesia, aphasia, convulsion, memory impairment, cognitive disorder

Uncommon (0.1% to 1%): Speech disorder

Other

Very common (10% or more): Pyrexia (up to 62%), peripheral edema (up to 25%), fatigue (up to 17%), chills (up to 15%), chest pain (up to 11%)

INVESTIGATIONS:

Very common (10% or more): Increased alanine aminotransferase (up to 12%), increased aspartate aminotransferase (up to 11%)

Psychiatric

Very common (10% or more): Insomnia (up to 15%),

Common (1% to 10%): Confusion, disorientation

Respiratory

Very common (10% or more): Cough (up to 19%), dyspnea (e.g., acute respiratory failure, bronchial hyperactivity, bronchospasm, dyspnea, dyspnea exertional, respiratory distress, respiratory failure, wheezing) (up to 15%)

Uncommon (0.1% to 1%): Bronchospasm

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Blincyto (www.drugs.com/mtm/blincyto.html).