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Bisoprolol is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins).
Bisoprolol is used to treat hypertension (high blood pressure).
Bisoprolol may also be used for purposes not listed in this medication guide.
Do not skip doses or stop taking bisoprolol without first talking to your doctor. Stopping suddenly may make your condition worse or cause other serious heart problems.
If you need to have any type of surgery, tell the surgeon ahead of time that you are using this medicine.
You should not use bisoprolol if you have a serious heart condition such as "AV block," severe heart failure, or slow heartbeats that have caused you to faint.
Keep using bisoprolol as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
You should not use bisoprolol if you you are allergic to it, or if you have a serious heart condition such as:
"AV block";
severe heart failure; or
slow heartbeats that have caused you to faint.
To make sure bisoprolol is safe for you, tell your doctor if you have:
congestive heart failure or other heart problems;
coronary artery disease;
circulation problems (such as Peripheral Vascular Disease or Raynaud's syndrome);
asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;
diabetes (taking bisoprolol can make it harder for you to tell when you have low blood sugar);
liver or kidney disease;
a thyroid disorder; or
a history of allergies.
It is not known whether bisoprolol is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether bisoprolol passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Bisoprolol is not approved for use by anyone younger than 18 years old.
Take bisoprolol exactly as it was prescribed for you. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Do not skip doses or stop taking bisoprolol without first talking to your doctor. Stopping suddenly may make your condition worse or cause other serious heart problems.
If you need surgery, tell the surgeon ahead of time that you are using bisoprolol.
Your blood pressure will need to be checked often.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Store bisoprolol at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Minimize drinking alcohol. It can increase some of the side effects of bisoprolol.
Get emergency medical help if you have signs of an allergic reaction to bisoprolol: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
shortness of breath (even with mild exertion), swelling, rapid weight gain;
slow heart rate;
pounding heartbeats or fluttering in your chest;
numbness, tingling, or cold feeling in your hands or feet;
a light-headed feeling, like you might pass out;
eye pain, vision problems; or
bronchospasm (wheezing, chest tightness, trouble breathing).
Common bisoprolol side effects may include:
headache;
feeling tired;
sleep problems (insomnia);
joint pain;
swelling; or
cold symptoms such as stuffy nose, runny nose, cough, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all your current medicines and any you start or stop using, especially:
insulin or oral diabetes medicine;
rifampin; or
heart or blood pressure medicine--clonidine, digitalis, digoxin, diltiazem, reserpine, or verapamil.
This list is not complete. Other drugs may interact with bisoprolol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use bisoprolol only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Bisoprolol Fumarate/hydro (www.drugs.com/bisoprolol.html).
More frequently reported side effects include: fatigue. See below for a comprehensive list of adverse effects.
Applies to bisoprolol: oral tablet
Along with its needed effects, bisoprolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking bisoprolol:
Less common
Rare
Get emergency help immediately if any of the following symptoms of overdose occur while taking bisoprolol:
Symptoms of overdose
Some side effects of bisoprolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Applies to bisoprolol: oral tablet
The more commonly reported side effects observed with this drug are bradycardia, dizziness, and hypotension.
Bradycardia occurred as a dose-related event.
Cardiac failure occurred in 18.4% of patients (n=1328) compared with 22.8% of placebo-treated patients (n=1321).
Very common (10% or more): Bradycardia (up to 15.2%)
Common (1% to 10%): Chest pain, heart failure aggravation, hypotension, cold extremities, peripheral edema, ischemia, conduction disorder, left cardiac failure, palpitation, vein disorder
Uncommon (0.1% to 1%): Atrioventricular (AV) disturbances, orthostatic hypotension
Frequency not reported: Other rhythm disturbances, claudication
Very common (10% or more): Dizziness (up to 13.3%)
Common (1% to 10%): Headache, extremity numbness, cerebrovascular disorder, syncope, hypoesthesia
Frequency not reported: Vertigo, paresthesia, hypoesthesia, hyperesthesia, somnolence, decreased concentration/memory, tremor, taste abnormalities
Postmarketing reports: Unsteadiness
Very common (10% or more): Dyspnea (up to 13.8%)
Common (1% to 10%): Pneumonia, bronchitis, coughing, exertional dyspnea, upper respiratory tract infection, respiratory distress, stridor, respiratory tract edema, respiratory tract hemorrhage, sinusitis
Uncommon (0.1% to 1%): Bronchospasm
Rare (0.01% to 0.1%): Allergic rhinitis
Sinusitis occurred as a dose-related event.
Very common: Antinuclear antibody (ANA) conversions (up to 15%)
Common (1% to 10%): Viral infection
Common (1% to 10%): Pruritus
Uncommon (0.1% to 1%): Sweating
Rare (0.01% to 0.1%): Itching, flushing, rash
Very rare (less than 0.01%): Alopecia, psoriasis-like rash, psoriasis exacerbation
Frequency not reported: Acne, eczema, skin irritation, cutaneous vasculitis
Postmarketing reports: Dermatitis, exfoliative dermatitis
Diarrhea occurred as a dose-related event.
Common (1% to 10%): Nausea, vomiting, diarrhea, constipation, dyspepsia, epigastric pain (not food related), abdominal pain, gastritis, dry mouth
Frequency not reported: Gastric pain, peptic ulcer
Common (1% to 10%): Purine metabolism disorder, carbohydrate metabolism disturbed, weight changes, cholesterol changes, potassium levels altered, blood lipid changes
Rare (0.01% to 0.1%): Increased triglycerides
Frequency not reported: Gout
Postmarketing reports: Increased uric acid and glucose
Uric acid, serum potassium, glucose, and phosphorus increases associated with use of this drug were not of clinical importance and rarely resulted in discontinuation.
Common (1% to 10%): Limb pain, myalgia, arthropathy, arthralgia
Uncommon (0.1% to 1%): Muscular weakness, cramps
Frequency not reported: Back pain, neck pain, twitching
Common (1% to 10%): Asthenia, fatigue, body pain, fever, malaise
Rare (0.01% to 0.1%): Hearing disorders
Frequency not reported: Earache, tinnitus
Fatigue and asthenia occurred as dose-related events.
Common (1% to 10%): Insomnia, anxiety
Uncommon (0.1% to 1%): Sleep disorders, depression
Rare (0.01% to 0.1%): Nightmares, hallucinations
Frequency not reported: Restlessness
Common (1% to 10%): Urinary tract infection
Rare (0.01% to 0.1%): Potency disorders
Frequency not reported: Decreased libido, Peyronie's disease, polyuria
Common (1% to 10%): Hepatomegaly
Rare (0.01% to 0.1%): Increased liver enzymes (ALT, AST), hepatitis
Transaminase elevations of 1 to 2 times the upper limit of normal were reported in 6.2% of patients, with a multiple occurrence rate of 1.9%. Generally, this increase was the result of underlying disorders or resolved with continued use of this drug.
Rare (0.01% to 0.1%): Hypersensitivity
Postmarketing reports: Angioedema
Of the 15% of patients who developed positive ANA status, one-third of patients converted back to a negative titer with continued use.
Rare (0.01% to 0.1%): Reduced tear flow
Very rare (less than 0.01%): Conjunctivitis
Frequency not reported: Visual disturbances, ocular pain, ocular pressure
Creatinine and BUN were associated with slightly increased levels, but these effects were generally not of clinical importance and rarely resulted in discontinuation.
Frequency not reported: Cystitis, renal colic
Postmarketing reports: Increased creatinine and BUN
During treatment with this drug, decreased levels of WBCs and platelets were not of clinical importance and rarely resulted in discontinuation.
Postmarketing reports: Purpura, decreases in WBC and platelets
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Bisoprolol Fumarate/hydro (www.drugs.com/bisoprolol.html).
June 26, 2020
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