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Generic Name: benzoyl peroxide and erythromycin topical (BEN zoe ill per OX ide and er ith roe MYE sin)
Brand Name: Benzamycin
Physician reviewed Benzamycin patient information - includes Benzamycin description, dosage and directions.
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Drug Information:
Benzoyl Peroxide has an antibacterial effect. It also has a mild drying effect that allows excess oils and dirt to be easily washed away. Erythromycin is an antibiotic. Erythromycin topical prevents bacteria from growing on the skin. Benzamycin (for the skin) is a combination medicine used to treat acne. Benzamycin may also be used for purposes not listed in this medication guide. Benzamycin can cause a rare but serious allergic Reaction or severe skin irritation. Stop using this medicine and get emergency medical help if you have: hives, itching; difficult breathing, feeling light-headed; or swelling of your face, lips, tongue, or throat. Learn more

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Benzamycin Side Effects

Note: This document contains side effect information about benzoyl peroxide / erythromycin topical. Some of the dosage forms listed on this page may not apply to the brand name Benzamycin.

For the Consumer

Applies to benzoyl peroxide/erythromycin topical: topical gel/jelly

Along with its needed effects, benzoyl peroxide/erythromycin topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking benzoyl peroxide/erythromycin topical:

Less common or rare

  • Burning, blistering, crusting, itching, severe redness, or swelling of the skin
  • dryness or peeling of the skin
  • eye irritation
  • feeling of warmth, mild stinging, or redness of the skin
  • increased sensitivity of the skin to sunlight
  • oiliness or tenderness of the skin
  • painful irritation of the skin
  • redness or other discoloration of the skin
  • redness, swelling, or itching of the eyelid
  • severe sunburn
  • skin rash
  • swelling of the eyes, face, and nose

For Healthcare Professionals

Applies to benzoyl peroxide / erythromycin topical: topical gel


Common (1% to 10%): Dry skin, pruritus, photosensitivity reaction (sunburn, stinging with sun exposure), dryness, urticarial reaction

Uncommon (0.1% to 1%): Peeling

Frequency not reported: Skin discoloration, skin oiliness, tenderness of the skin, transient drying, erythema, burning, desquamation

Erythromycin topical:

-Frequency not reported: Generalized urticarial reaction


Common (1% to 10%): Application site reaction (stinging, erythema, burning)

Frequency not reported: Irritation of the skin (including peeling, itching, burning sensation, erythema, inflammation of the face/eyes/nose, irritation of the eyes)


Common (1% to 10%): Blepharitis


Benzoyl peroxide topical:

-Frequency not reported: Allergic sensitization

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Benzamycin (www.drugs.com/mtm/benzamycin.html).