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Beleodaq

Generic Name: belinostat (be LIN oh stat)
Brand Names: Beleodaq
Beleodaq (belinostat) interferes with the growth and spread of cancer cells in the body and is used to treat peripheral T-cell lymphoma. Includes Beleodaq side effects, interactions and indications.
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Drug Information:
Beleodaq (belinostat) is a cancer medication that interferes with the growth and spread of cancer cells in the body. Beleodaq is used to treat peripheral T-cell lymphoma that has relapsed or has not responded to other treatments. Beleodaq was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, non-small cell lung tumors responded to this medicine. However, it has not been shown that belinostat can improve symptoms or lengthen survival time. You should not use Beleodaq if you have an active infection. Learn more

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Beleodaq Side Effects

Note: This document contains side effect information about belinostat. Some of the dosage forms listed on this page may not apply to the brand name Beleodaq.

In Summary

Common side effects of Beleodaq include: anemia, diarrhea, nausea, thrombocytopenia, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to belinostat: intravenous powder for solution

Along with its needed effects, belinostat (the active ingredient contained in Beleodaq) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking belinostat:

More common

  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • bluish color
  • blurred vision
  • changes in skin color
  • chest pain
  • confusion
  • cough
  • decreased urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • fast heartbeat
  • fever or chills
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • pale skin
  • pinpoint red spots on the skin
  • rapid, shallow breathing
  • sore throat
  • sweating
  • tenderness
  • tightness in the chest
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss

Incidence not known

  • Abdominal or stomach pain or tenderness
  • clay colored stools
  • dark urine
  • decreased appetite
  • headache
  • joint pain, stiffness, or swelling
  • lower back or side pain
  • skin rash or itching
  • yellow eyes or skin

Some side effects of belinostat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Constipation
  • diarrhea
  • dizziness
  • pain at the injection site

For Healthcare Professionals

Applies to belinostat: intravenous powder for injection

General

The most commonly observed adverse reactions included nausea, fatigue, pyrexia, anemia, and vomiting.

The most commonly reported reasons for treatment discontinuation included anemia, febrile neutropenia, fatigue, and multi-organ failure.

Hematologic

Very common (10% or more): Anemia (32%), thrombocytopenia (16%)

Cardiovascular

Very common (10% or more): Peripheral edema (20%), prolonged QT (11%), hypotension (10%), phlebitis (10%)

Dermatologic

Very common (10% or more): Rash (20%), pruritus (16%)

Gastrointestinal

Very common (10% or more): Nausea (43%), vomiting (29%), constipation (23%), diarrhea (23%), decreased appetite (15%), abdominal pain (11%)

Metabolic

Very common (10% or more): Hypokalemia (12%)

Nervous system

Very common (10% or more): Headache (15%), dizziness (10%)

Other

Very common (10% or more): Fatigue (37%), pyrexia (35%), chills (16%)

Respiratory

Very common (10% or more): Dyspnea (22%), cough (19%)

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Beleodaq (www.drugs.com/beleodaq.html).