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Baxdela

Generic Name: delafloxacin (oral/injection) (DEL a FLOX a sin)
Brand Names: Baxdela
Baxdela (delafloxacin) is used to treat acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). Includes Baxdela indications, interactions, and side effects.
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Drug Information:
Baxdela (delafloxacin) is a fluoroquinolone (flor-o-KWIN-o-lone) antibiotic that fights bacteria in the body. Baxdela is used to treat different types of bacterial infections of the skin. Baxdela is also used to treat community-acquired bacterial pneumonia. Fluoroquinolone antibiotics can cause serious or disabling side effects. Baxdela should be used only for infections that cannot be treated with a safer antibiotic. Baxdela can cause serious side effects, including tendon problems, nerve damage, serious mood or behavior changes, or low blood sugar. Learn more

Baxdela Side Effects

Baxdela Side Effects

Note: This document contains side effect information about delafloxacin. Some of the dosage forms listed on this page may not apply to the brand name Baxdela.

For the Consumer

Applies to delafloxacin: oral tablet

Other dosage forms:

  • intravenous powder for solution

Warning

Oral route (Tablet)

Fluoroquinolones have been associated with disabling and potentially irreversible serious adverse reactions that have occurred together, including tendinitis and tendon rupture, peripheral neuropathy, and central nervous system effects. Discontinue delafloxacin immediately and avoid the use of fluoroquinolones, including delafloxacin, in patients who experience any of these serious adverse reactions. Fluoroquinolones may exacerbate muscle weakness in patients with myasthenia gravis. Avoid delafloxacin in patients with known history of myasthenia gravis.

Along with its needed effects, delafloxacin (the active ingredient contained in Baxdela) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking delafloxacin:

More common

  • Diarrhea

Less common

  • Anxiety
  • bloody urine
  • bluish color of the skin
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in taste
  • changes in skin color
  • chest pain or discomfort
  • chills
  • cold sweats
  • confusion
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cool, pale skin
  • cough
  • decreased frequency or amount of urine
  • depression
  • difficulty in moving
  • dizziness or lightheadedness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fast, slow, irregular, pounding, or racing heartbeat or pulse
  • feeling of constant movement of self or surroundings
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • hearing loss
  • hives, itching, skin rash
  • hoarseness
  • increased blood pressure
  • increased hunger
  • increased thirst
  • increased urination
  • irritation
  • joint pain, stiffness, or swelling
  • loss of appetite
  • loss of consciousness
  • loss of taste
  • lower back or side pain
  • muscle cramps, pains, or stiffness
  • nausea
  • nervousness
  • painful or difficult urination
  • pounding in the ears
  • redness of the skin
  • seizures
  • sensation of spinning
  • shakiness
  • slurred speech
  • stomach pain
  • swelling of the eyelids, face, lips, hands, fingers, lower legs, or feet
  • swollen joints
  • tenderness, pain, swelling, warmth, skin discoloration, or prominent superficial veins over the affected area
  • tightness in the chest
  • troubled breathing or swallowing
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting
  • weight gain

Some side effects of delafloxacin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Abnormal dreams
  • belching
  • feeling of warmth
  • heartburn
  • indigestion
  • pain or redness at the injection site
  • redness of the face, neck, arms, and occasionally, the upper chest
  • stomach discomfort, upset, or pain
  • trouble sleeping

Some side effects of delafloxacin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For Healthcare Professionals

Applies to delafloxacin: intravenous powder for injection, oral tablet

General

The most common side effects were nausea, diarrhea, headache, transaminase elevations, and vomiting. This drug was discontinued due to a side effect in 0.9% of patients; therapy was discontinued most commonly due to urticaria and hypersensitivity.

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, vomiting

Frequency not reported: Abdominal pain, dyspepsia, oral candidiasis, Clostridium difficile-associated diarrhea

Nervous system

Cases of sensory or sensorimotor axonal polyneuropathy (affecting small and/or large axons) resulting in paresthesias, hypoesthesias, dysesthesias, and weakness have been reported.

Common (1% to 10%): Headache

Frequency not reported: Dizziness, hypoesthesia, paresthesia, dysgeusia, presyncope, syncope, tinnitus, vertigo, sensory axonal polyneuropathy, sensorimotor axonal polyneuropathy, dysesthesia

Fluoroquinolones:

-Frequency not reported: Peripheral neuropathy, central nervous system (CNS) effects (convulsions, increased intracranial pressure [including pseudotumor cerebri], toxic psychosis, severe headaches)

-Postmarketing reports: Exacerbation of myasthenia gravis

Hepatic

Common (1% to 10%): Transaminase elevations (includes hypertransaminasemia, increased transaminases, increased ALT and AST)

Musculoskeletal

Frequency not reported: Increased blood creatine phosphokinase, myalgia

Fluoroquinolones:

-Frequency not reported: Tendinitis, tendon rupture, arthralgia

Hypersensitivity

Frequency not reported: Hypersensitivity

Fluoroquinolones:

-Frequency not reported: Serious and sometimes fatal hypersensitivity (anaphylactic) reactions

Psychiatric

Frequency not reported: Anxiety, insomnia, abnormal dreams

Fluoroquinolones:

-Frequency not reported: CNS effects (hallucinations, anxiety, depression, insomnia, confusion)

Cardiovascular

Frequency not reported: Sinus tachycardia, palpitations, bradycardia, hypotension, hypertension, phlebitis

Dermatologic

Frequency not reported: Pruritus, urticaria, dermatitis, rash

Renal

Frequency not reported: Increased blood creatinine, renal impairment, renal failure

Other

Frequency not reported: Increased blood alkaline phosphatase, flushing, weakness, C difficile infection, fungal infection

Metabolic

Frequency not reported: Hyperglycemia, hypoglycemia

Other fluoroquinolones:

-Frequency not reported: Blood glucose disturbances

Local

Frequency not reported: Infusion site extravasation, infusion site bruise, infusion site discomfort, infusion site edema, infusion site erythema, infusion site irritation, infusion site pain, infusion site phlebitis, infusion site swelling, infusion site thrombosis

Genitourinary

Frequency not reported: Vulvovaginal candidiasis

Ocular

Frequency not reported: Blurred vision

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Baxdela (www.drugs.com/baxdela.html).