Atorvastatin Calcium

Commonly reported side effects of atorvastatin include: hemorrhagic stroke, arthralgia, diarrhea, and nasopharyngitis. Other side effects include: urinary tract infection, insomnia, limb pain, muscle spasm, musculoskeletal pain, myalgia, and nausea. See below for a comprehensive list of adverse effects.

Applies to atorvastatin: oral tablet

Along with its needed effects, atorvastatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking atorvastatin:

Less common or rare

• Cough
• difficulty with swallowing
• dizziness
• fast heartbeat
• fever
• hives
• itching
• muscle cramps, pain, stiffness, swelling, or weakness
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• skin rash
• tightness in the chest
• unusual tiredness or weakness
• wheezing

Incidence not known

• Blistering, peeling, or loosening of the skin
• chills
• dark-colored urine
• diarrhea
• joint pain
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• red skin lesions, often with a purple center sore
• red, irritated eyes
• sore throat
• sores, ulcers, or white spots in the mouth or on the lips

Some side effects of atorvastatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Headache
• hoarseness
• lower back or side pain
• pain or tenderness around the eyes and cheekbones
• painful or difficult urination
• stuffy or runny nose

Less common

• Abdominal or stomach pain
• back pain
• belching or excessive gas
• constipation
• general feeling of discomfort or illness
• heartburn, indigestion, or stomach discomfort
• lack or loss of strength
• loss of appetite
• nausea
• shivering
• sweating
• trouble sleeping
• vomiting

Incidence not known

• Appetite increased
• black, tarry stools
• bloody nose
• bloody or cloudy urine
• blurred vision
• continuing ringing or buzzing or other unexplained noise in the ears
• difficult, burning, or painful urination
• difficulty seeing at night
• excessive muscle tone or tension
• fruit-like breath odor
• groin or scrotum pain
• inability to have or keep an erection
• increased body movements
• increased sensitivity of the eyes to light
• increased sensitivity to touch or pain
• increased thirst
• increased urination
• loss of bladder control
• loss of sexual ability, drive, or desire
• menstrual bleeding occurring earlier or lasting longer than usual
• mental depression
• nervousness
• nightmares
• pale skin
• paranoia
• pinpoint red spots on the skin
• slurred speech
• swollen or tender lymph glands in the neck, armpit, or groin
• unable to move or feel face
• unusual bleeding or bruising
• weight loss

Applies to atorvastatin: oral tablet

The most frequently reported side effects were nasopharyngitis, arthralgia, diarrhea, pain in extremity, and urinary tract infection.

Very common (10% or more): Diarrhea (up to 14.1%)

Common (1% to 10%): Dyspepsia, nausea, flatulence, constipation

Uncommon (0.1% to 1%): Abdominal discomfort, eructation, abdominal pain, vomiting, pancreatitis

Common (1% to 10%): Blood bilirubin increased, ALT increased, transaminases/hepatic enzymes increased, AST increased, liver function test abnormal, blood alkaline phosphatase increased

Uncommon (0.1% to 1%): Hepatitis

Rare (0.01% to 0.1%): Cholestasis

Very rare (less than 0.1%): Fatal hepatic failure, nonfatal hepatic failure

Very common (10% or more): Arthralgia (up to 11.7%)

Common (1% to 10%): Pain in extremity, musculoskeletal pain, muscle spasms, myalgia, joint swelling, back pain, creatine phosphokinase increased

Uncommon (0.1% to 1%): Neck pain, muscle fatigue

Rare (less than 0.1%): Myositis, myopathy, rhabdomyolysis, tendinopathy

Frequency not reported: Immune-mediated necrotizing myopathy

Postmarketing reports: Tendon rupture

Rare (less than 0.1%): Thrombocytopenia

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Paresthesia, dizziness, hypoesthesia, dysgeusia, amnesia

Rare (less than 0.1%): Peripheral neuropathy

Frequency not reported: Nonfatal hemorrhagic stroke

Postmarketing reports: Cognitive impairment, memory loss, forgetfulness, memory impairment

Very rare (less than 0.01%): Gynecomastia

Common (1% to 10%): Allergic reactions

Rare (less than 0.1%): Anaphylaxis, hypersensitivity reaction

Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Nightmare

Postmarketing reports: Confusion, depression

Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): White blood cells urine positive, erectile dysfunction

Uncommon (0.1% to 1%): Rash, pruritus, urticaria, alopecia

Rare (less than 0.1%): Angioneurotic edema/angioedema, bullous rashes, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis

Frequency not reported: Urticaria

Common (1% to 10%): Cardiovascular death

Very common (10% or more): Nasopharyngitis (up to 12.9%)

Common (1% to 10%): Pharyngolaryngeal pain, epistaxis

Uncommon (0.1% to 1%): Asthma

Rare (less than 0.1%): Sinusitis, pharyngitis

Frequency not reported: Interstitial lung disease

Uncommon (0.1% to 1%): Vision blurred

Rare (less than 0.1%): Visual disturbance

Common (1% to 10%): Non-cardiovascular death

Uncommon (0.1% to 1%): Deafness, tinnitus, malaise, asthenia, influenza, infection, chest pain, peripheral edema, fatigue, pyrexia

Rare (0.01% to 0.1%): Injury

Very rare (less than 0.01%): Hearing loss

Common (1% to 10%): Hyperglycemia

Uncommon (0.1% to 1%): Anorexia, hypoglycemia, weight increased

Frequency not reported: Diabetes mellitus