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Aspirin Prescription
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Generic Name: aspirin (oral) (AS pir in)
Brand Names: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin
Aspirin is used to treat mild to moderate pain and to reduce fever or inflammation. Learn about side effects, interactions, indications and more...
Generic Name: aspirin (oral) (AS pir in)
Brand Names: Arthritis Pain, Aspir 81, Aspir-Low, Bayer Childrens Aspirin, Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin
Aspirin is used to treat mild to moderate pain and to reduce fever or inflammation. Learn about side effects, interactions, indications and more...
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1 tablets of Aspirin 40 mg
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Aspirin Drug Information:

Aspirin is a salicylate (sa-LIS-il-ate). It works by reducing substances in the body that cause pain, fever, and inflammation. Aspirin is used to treat pain, and reduce fever or inflammation. It is sometimes used to treat or prevent heart attacks, strokes, and chest pain (angina). Aspirin should be used for cardiovascular conditions only under the supervision of a doctor. You should not use aspirin if you have a bleeding disorder such as hemophilia, a recent history of stomach or intestinal bleeding, or if you are allergic to an NSAID (non-steroidal anti-inflammatory drug) such as Advil, Motrin, Aleve, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others. Learn more

Aspirin Side Effects

In Summary

More frequently reported side effects include: dyspepsia, epigastric discomfort, heartburn, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to aspirin: oral capsule extended release 24 hr, oral gum, oral tablet, oral tablet chewable, oral tablet enteric coated

Along with its needed effects, aspirin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking aspirin:

Incidence not known

  • Abdominal or stomach pain, cramping, or burning
  • black, tarry stools
  • bloody or cloudy urine
  • change in consciousness
  • chest pain or discomfort
  • confusion
  • constipation
  • convulsions, severe or continuing
  • dark urine
  • decreased frequency or amount of urine
  • diarrhea
  • difficult breathing
  • drowsiness
  • fainting
  • fast breathing
  • feeling that something terrible will happen
  • fever
  • general tiredness and weakness
  • greatly decreased frequency of urination or amount of urine
  • headache
  • heartburn
  • increased thirst
  • indigestion
  • irregular heartbeat
  • light-colored stools
  • loss of appetite
  • loss of consciousness
  • lower back or side pain
  • muscle cramping and weakness
  • muscle tremors
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • panic
  • rapid, deep breathing
  • restlessness
  • seizures
  • skin rash
  • stomach cramps
  • swelling of the face, fingers, or lower legs
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • weakness or heaviness of the legs
  • weight gain
  • yellow eyes and skin

Some side effects of aspirin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Acid or sour stomach
  • anxiety
  • belching
  • dizziness
  • dry mouth
  • hyperventilation
  • irritability
  • shaking
  • stomach discomfort, upset, or pain
  • trouble sleeping
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

For Healthcare Professionals

Applies to aspirin: compounding powder, oral capsule extended release, oral delayed release capsule, oral delayed release tablet, oral gum, oral powder for reconstitution, oral tablet, oral tablet chewable, oral tablet disintegrating, oral tablet dispersible, oral tablet extended release, rectal suppository


Common (1% to 10%): Dyspepsia,

Frequency not reported: GI bleeding, ulceration, perforation, nausea, vomiting, pancreatitis, gastric irritation, GI erosions, gastritis, melena, hematemesis, gingival bleeding


Frequency not reported: Interstitial nephritis, papillary necrosis, renal insufficiency and failure


Common (1% to 10%): Increased bleeding tendencies

Rare (0.01% to 0.1%): Aplastic anemia agranulocytosis, thrombocytopenia

Frequency not reported: Prolongation of prothrombin time, disseminated intravascular coagulation, coagulopathy, antepartum and postpartum bleeding, anemia


Rare (0.01% to 0.1%): Anaphylactic reactions including shock

Frequency not reported: Urticaria, angioedema, skin rashes


Uncommon (0.1% to 1%): Urticaria

Rare (0.01% to 0.1%): Steven-Johnson syndrome, Lyell's syndrome, erythema nodosum, erythema multiforme

Frequency not reported: Purpura, hives


Frequency not reported: Transient elevations of hepatic enzymes, hepatitis, Reye's syndrome, hepatic insufficiency


Frequency not reported: Thirst, dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis, hypoglycemia, hyperglycemia, hyperuricemia, salt and water retention


Rare (0.01% to 0.1%): Hemorrhagic vasculitis

Frequency not reported: Dysrhythmias, hypotension, tachycardia

Nervous system

Frequency not reported: Cerebral edema, coma headache, subdural or intracranial hemorrhage, seizures, lethargy, dizziness


Frequency not reported: Fever, hypothermia, hearing loss, tinnitus (at high doses), hearing disturbances


Frequency not reported: Rhabdomyolysis


Frequency not reported: Hyperpnea, pulmonary edema, tachypnea, epistaxis, dyspnea, bronchospasm, asthma


The more commonly experienced adverse effects include indigestion, dyspepsia, bleeding, and bruising.


Rare (0.01% to 0.1%): Menorrhagia

Frequency not reported: Proteinuria


Frequency not reported: Agitation, confusion

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Aspirin (www.drugs.com/aspirin.html).