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Asclera

Generic Name: laureth-9 (polidocanol) (LAWR eth-9 (pol i DOE ka nol))
Brand Names: Asclera, Varithena
Asclera (laureth-9 - polidocanol) is used to spider veins and varicose veins in the legs. Includes Asclera side effects, interactions and indications.
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Drug Information:
Asclera (laureth-9) is a sclerosing agent. It works by increasing the formation of blood clots and scar tissue inside certain types of veins. This helps decrease dilation of enlarged veins. Asclera is used to treat small uncomplicated spider veins and varicose veins in the legs. Asclera will not treat varicose veins that are larger than 3 millimeters (about one-eighth of an inch) in diameter. Asclera is not a cure for varicose veins and the effects of this medication may not be permanent. Asclera may also be used for purposes not listed in this medication guide. Learn more

Asclera Side Effects

Asclera Side Effects

Note: This document contains side effect information about polidocanol. Some of the dosage forms listed on this page may not apply to the brand name Asclera.

In Summary

Common side effects of Asclera include: hematoma at injection site, hematoma, pain at injection site, and skin discoloration at injection site. Other side effects include: pain. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to polidocanol: intravenous foam, intravenous solution

Along with its needed effects, polidocanol (the active ingredient contained in Asclera) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking polidocanol:

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • collection of blood under the skin of the injection site
  • deep, dark purple bruise at the injection site

Incidence not known

  • Anxiety
  • blue-green to black skin discoloration
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • cough
  • darkening of the skin
  • difficult or labored breathing
  • difficulty with swallowing
  • dizziness or lightheadedness
  • fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • inability to speak
  • increased hair growth in the treatment area
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • loss of consciousness
  • nerve injury
  • no blood pressure or pulse
  • noisy breathing
  • pain, redness, or sloughing of the skin at the injection site
  • pain, redness, or swelling in the arm or leg
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • seizures
  • severe or sudden headache
  • skin rash
  • slurred speech
  • sores, welts, or blisters
  • stopping of the heart
  • temporary blindness
  • tightness in the chest
  • troubled breathing
  • unusual tiredness or weakness
  • weakness in the arm or leg on one side of the body, sudden and severe

Get emergency help immediately if any of the following symptoms of overdose occur while taking polidocanol:

Symptoms of overdose

  • Break in the skin, especially associated with blue-black discoloration, swelling, or drainage of fluid

Some side effects of polidocanol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Confusion
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest
  • sudden sweating

For Healthcare Professionals

Applies to polidocanol: injectable foam, injectable kit, injectable solution

Local

Very common (10% or more): Injection site hematoma (up to 42%), injection site irritation (up to 41%), injection site discoloration (up to 38%), injection site pain (up to 24%), injection site pruritus (up to 19%), injection site warmth (up to 16%)

Common (1% to 10%): Injection site thrombosis (local intravaricose blood clots)

Uncommon (0.1% to 1%): Injection site necrosis, induration, swelling

Hypersensitivity

Very rare (less than 0.01%): Anaphylactic shock

Respiratory

Very rare (less than 0.01%): Asthma attack, dyspnea, chest discomfort, cough

Cardiovascular

Common (1% to 10%): Neovascularization, hematoma

Uncommon (0.1% to 1%): Thrombophlebitis superficial, phlebitis

Rare (0.01% to 0.1%): Deep vein thrombosis

Very rare (less than 0.01%): Cerebrovascular accident, migraine, pulmonary embolism, syncope vasovagal, circulatory collapse, vasculitis, blood pressure abnormal, heart rate abnormal (tachycardia, bradycardia)

Frequency not reported: Cardiac arrest, palpitations, hot flush

Nervous system

Uncommon (0.1% to 1%): Nerve injury

Very rare (less than 0.01%): Headache, paresthesia (local), loss of consciousness, confusional state, dizziness, aphasia, ataxia, hemiparesis, hypoesthesia oral

Frequency not reported: Migraine

Dermatologic

Common (1% to 10%): Rash, ecchymosis, skin hyperpigmentation

Uncommon (0.1% to 1%): Allergic dermatitis, skin reaction, erythema

Very rare (less than 0.01%): Angioedema, generalized urticaria, hypertrichosis (in the area of sclerotherapy)

Gastrointestinal

Very rare (less than 0.01%): dysgeusia, nausea, vomiting

Musculoskeletal

Very common (10% or more): Pain in extremity (up to 65%), limb discomfort (up to 32%)

Other

Very rare (less than 0.01%): Pyrexia, asthenia, malaise

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Asclera (www.drugs.com/asclera.html).