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Aranesp Albumin Free

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Aranesp albumin free Prescription
Generic Name: darbepoetin alfa (DAR be POE e tin AL fa)
Brand Names: Aranesp
Aranesp (darbepoetin alfa) is used to treat anemia - a lack of red blood cells in the body. Includes Aranesp side effects, interactions and indications.
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Aranesp Albumin Free Drug Information:

Aranesp (darbepoetin alfa) is a man-made form of a protein that helps your body produce red blood cells. This protein may be reduced when you have kidney failure or use certain medications. When fewer red blood cells are produced, you can develop a condition called anemia. Aranesp is used to treat anemia caused by chemotherapy or chronic kidney disease. Aranesp can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Seek emergency medical help if you have: chest pain, shortness of breath, sudden numbness or weakness, confusion, problems with vision or balance, trouble speaking or understanding, or pain or coldness in an arm or leg. Learn more

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Aranesp Albumin Free Side Effects

Note: This document contains side effect information about darbepoetin alfa. Some of the dosage forms listed on this page may not apply to the brand name Aranesp.

In Summary

Common side effects of Aranesp include: hypertension and peripheral edema. Other side effects include: congestive heart failure and hypervolemia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to darbepoetin alfa: injection solution


Injection route (Solution)

Erythropoiesis-stimulating agents (ESAs) increase the risk for death, myocardial infarction, stroke, and other serious cardiovascular events. Patients with chronic kidney disease (CKD) were at a greater risk for death, serious adverse cardiovascular reactions, and stroke when administered ESAs to target Hb levels of greater than 11 g/dL in clinical studies. No trial has identified a Hb target level, ESA dose, or dosing strategy that does not increase these risks. In CKD patients, use the lowest sufficient dose to reduce the need for RBC transfusions. In cancer patients with certain tumor types (ie, breast, non-small cell lung, head and neck, lymphoid, cervical), ESAs shortened overall survival and increased the risk of tumor progression or recurrence in clinical studies. In cancer patients, use the lowest dose needed to avoid RBC transfusions to reduce these risks and the risk of serious cardiovascular and thromboembolic reactions. Use ESAs only for treatment of anemia due to concomitant myelosuppressive chemotherapy, and discontinue following the completion of a chemotherapy course. Patients receiving myelosuppressive therapy when the anticipated outcome is cure should not be treated with ESAs.

Along with its needed effects, darbepoetin alfa (the active ingredient contained in Aranesp) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking darbepoetin alfa:

More common

  • Accumulation of pus
  • arm, back, or jaw pain
  • blurred vision
  • breathing problems (irregular, noisy, or trouble when resting)
  • chest pain, discomfort, tightness, or heaviness
  • chills
  • confusion
  • cough producing mucus
  • decrease in the amount of urine
  • diarrhea
  • dilated neck veins
  • dizziness, fainting, or lightheadedness
  • dry mouth
  • fast, slow, or irregular heartbeat
  • fatigue or tiredness (extreme or unusual)
  • fever
  • headache
  • nausea
  • pain, tenderness, swelling, or warmth over the injection site
  • pounding in the ears
  • rapid breathing
  • rapid or pounding pulse
  • skin discoloration at the injection site
  • stomach pain
  • sunken eyes
  • sweating
  • swelling of the ankles, face, fingers, feet, hands, or lower legs
  • thirst
  • trouble with breathing
  • unconsciousness
  • vomiting
  • weight gain
  • wrinkled skin

Less common

  • Anxiety
  • difficulty with speaking (slow speech or unable to speak)
  • double vision
  • seizures
  • trouble with thinking
  • trouble with walking
  • unable to move the arms, legs, or face muscles (including numbness and tingling)


  • Fever
  • hives, itching, skin rash
  • pale skin
  • sore throat

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • cough
  • joint or muscle pain
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • sores, ulcers, or white spots in mouth or on the lips

Some side effects of darbepoetin alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Constipation
  • general feeling of discomfort or illness
  • lack or loss of strength
  • loss of appetite
  • muscle aches, pains, or stiffness
  • runny nose
  • shivering
  • sneezing
  • trouble with sleeping

For Healthcare Professionals

Applies to darbepoetin alfa: injectable solution


The most common adverse reactions in patients with chronic kidney disease (CKD) were hypertension, dyspnea, peripheral edema, cough, and procedural hypotension. The most common adverse reactions in cancer patients receiving chemotherapy were abdominal pain, edema, and thrombovascular events.


Very common (10% or more): Nausea (up to 38%), vomiting (up to 27%), diarrhea (up to 20%), constipation (up to 19%), abdominal pain (up to 16%)

Common (1% to 10%): Dyspepsia


Very common (10% or more): Fatigue (up to 32%), fever (up to 19%), peripheral edema (up to 17%), asthenia (up to 16%), edema (up to 12.8%), procedural hypotension (10%), chest pain (up to 10%)

Common (1% to 10%): Death, influenza-like symptoms, fluid overload, fall, contusion, pain, arteriovenous graft thrombosis


Very common (10% or more): Hypertension (up to 31%), hypotension (up to 22%)

Common (1% to 10%): Myocardial infarction, thrombotic events, angina pectoris

Frequency not reported: Arrhythmia, thromboembolism, thrombosis, thrombophlebitis


Very common (10% or more): Myalgia (up to 20%), back pain (14%), arthralgia (up to 13%), limb pain (up to 11%)

Common (1% to 10%): Skeletal pain


Very common (10% or more): Dyspnea (up to 20%), upper respiratory infection (up to 14%), cough (up to 12%), nasopharyngitis (11%)

Common (1% to 10%): Bronchitis, sinusitis, sore throat, pulmonary embolism

Frequency not reported: Epistaxis, allergic bronchospasm

Nervous system

Very common (10% or more): Headache (up to 16%), dizziness (up to 14%)

Common (1% to 10%): Cerebrovascular accident/transient ischemic attack, convulsions, paresthesia, hypoesthesia, cerebrovascular disorders, stroke

Frequency not reported: Somnolence


Very common (10% or more): Urinary tract infection (15%)


Very common (10% or more): Chronic renal failure (15%)


Very common (10% or more): Hypoglycemia (14%)


Very common (10% or more): Insomnia (11%)

Common (1% to 10%): Depression, anxiety


Common (1% to 10%): Pruritus, cellulitis, rash, skin ulcer, alopecia

Frequency not reported: Angioedema, urticaria

Postmarketing reports: Severe cutaneous reaction


Common (1% to 10%): Injection site pain, access hemorrhage, access infection, vascular access thrombosis, vascular access complications


Common (1% to 10%): Granulocytopenia

Frequency not reported: Anemia, pure red cell aplasia associated with neutralizing antibodies to erythropoietin


Common (1% to 10%): Metastatic neoplasm


Frequency not reported: Serious allergic reaction, hypersensitivity reaction, anaphylactic reaction

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Aranesp Albumin Free (www.drugs.com/aranesp.html).