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Antabuse

Generic Name: disulfiram (dye SUL fi ram)
Brand Names: Antabuse
Antabuse interferes with the metabolism of alcohol and is used to treat chronic alcoholism. Learn about side effects, interactions and indications.

Average Savings for disulfiram (generic): 64.03%
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Drug Information:
Antabuse (Disulfiram) blocks an enzyme that is involved in processing Alcohol. Disulfiram produces very unpleasant side effects (such as fast heartbeat, chest pain, nausea, dizziness, flushing, and thirst) when combined with Alcohol in the body. Antabuse is used in certain people with chronic Alcoholism. This medicine can help keep you from drinking because of the unpleasant side effects that will occur if you consume Alcohol while taking Antabuse. Antabuse is used together with Therapy and counseling support to help you stop drinking. This medicine is not a cure for Alcoholism. Learn more

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Antabuse Side Effects

Note: This document contains side effect information about disulfiram. Some of the dosage forms listed on this page may not apply to the brand name Antabuse.

For the Consumer

Applies to disulfiram: oral tablet

Warning

Oral route (Tablet)

Disulfiram should never be administered to a patient when he is in a state of alcohol intoxication, or without his full knowledge. The physician should instruct relatives accordingly.

Along with its needed effects, disulfiram (the active ingredient contained in Antabuse) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking disulfiram:

Less common

  • Eye pain or tenderness or any change in vision
  • mood or mental changes
  • numbness, tingling, pain, or weakness in hands or feet

Rare

  • Darkening of urine
  • light gray-colored stools
  • severe stomach pain
  • yellow eyes or skin

Some side effects of disulfiram may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Drowsiness

Less common or rare

  • Decreased sexual ability in males
  • headache
  • metallic or garlic-like taste in mouth
  • skin rash
  • unusual tiredness

For Healthcare Professionals

Applies to disulfiram: oral tablet

Other

Frequency not reported: Fatigue

Hepatic

Rare (less than 0.1%): Altered liver function tests

Frequency not reported: Hepatic cell damage, hepatitis (cholestatic and fulminant), hepatic failure resulting in transplant or death, jaundice, cirrhosis

Nervous system

Frequency not reported: Drowsiness, peripheral neuritis, encephalopathy, polyneuritis, peripheral neuropathy, headache, seizures, lethargy

Dermatologic

Frequency not reported: Skin eruptions, acneiform eruptions, allergic dermatitis, maculopapular rash

Gastrointestinal

Frequency not reported: Nausea, vomiting, halitosis, metallic or garlic-like aftertaste, stomach upset

Ocular

Frequency not reported: Optic neuritis, eye pain or tenderness, changes in vision

Genitourinary

Frequency not reported: Decreased libido

Psychiatric

Frequency not reported: Psychotic reactions, depression, paranoia, schizophrenia, mania, confusion, personality changes, disorientation, memory impairment

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Antabuse (www.drugs.com/antabuse.html).