Amoxicillin

Applies to amoxicillin: oral capsule, oral powder for suspension, oral tablet, oral tablet chewable, oral tablet extended release

Along with its needed effects, amoxicillin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amoxicillin:

Incidence not known

• Abdominal or stomach cramps or tenderness
• back, leg, or stomach pains
• black, tarry stools
• bleeding gums
• blistering, peeling, or loosening of the skin
• bloating
• blood in the urine
• bloody nose
• chest pain
• chills
• clay-colored stools
• cough
• dark urine
• diarrhea
• diarrhea, watery and severe, which may also be bloody
• difficulty with breathing
• difficulty with swallowing
• dizziness
• fast heartbeat
• feeling of discomfort
• fever
• general body swelling
• headache
• heavier menstrual periods
• hives or welts
• increased thirst
• inflammation of the joints
• itching
• joint or muscle pain
• loss of appetite
• muscle aches
• nausea or vomiting
• nosebleeds
• pain
• pain in the lower back
• pain or burning while urinating
• painful or difficult urination
• pale skin
• pinpoint red spots on the skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rash
• red, irritated eyes
• redness, soreness, or itching skin
• shortness of breath
• sore throat
• sores, ulcers, or white spots in the mouth or on the lips
• sores, welting, or blisters
• sudden decrease in the amount of urine
• swollen, lymph glands
• tenderness
• tightness in the chest
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• unusual weight loss
• vomiting of blood
• watery or bloody diarrhea
• wheezing
• yellow eyes or skin

Some side effects of amoxicillin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Bad, unusual, or unpleasant (after) taste
• change in taste

Incidence not known

• Agitation
• black, hairy tongue
• changes in behavior
• confusion
• convulsions
• discoloration of the tooth (brown, yellow, or gray staining)
• dizziness
• sleeplessness
• trouble with sleeping
• unable to sleep
• white patches in the mouth or throat or on the tongue
• white patches with diaper rash

Applies to amoxicillin: oral capsule, oral powder for reconstitution, oral tablet, oral tablet chewable, oral tablet dispersible, oral tablet extended release

The most frequently reported side effects were diarrhea, nausea, and skin rash.

Common (1% to 10%): Diarrhea, nausea, abdominal pain

Uncommon (0.1% to 1%): Vomiting

Frequency not reported: Hemorrhagic/pseudomembranous colitis, tooth discolored, black hairy tongue, glossitis, stomatitis

Postmarketing reports: Sore mouth/tongue

Common (1% to 10%): Erythema, exanthema, rash

Uncommon (0.1% to 1%): Urticaria, pruritus

Very rare (less than 0.01%): Angioedema, hypersensitivity vasculitis

Frequency not reported: Erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson Syndrome, bullous dermatitis, exfoliative dermatitis, toxic epidermal necrolysis/Lyell's syndrome, acute generalized exanthematous pustulosis, maculopapular rash, erythema nodosum, pemphigoid reactions

Common (1% to 10%): Vulvovaginal mycotic infection

Common (1% to 10%): Headache, taste perversion

Very rare (less than 0.01%): Convulsion, dizziness, hyperkinesia

Frequency not reported: Reversible hyperactivity, central nervous system toxicity, encephalopathy

Very rare (less than 0.01%): Anaphylaxis, serum sickness-like reaction

Frequency not reported: Jarisch-Herxheimer reaction

Very rare (less than 0.01%): Crystalluria, interstitial nephritis

Frequency not reported: Nephropathy

Very rare (less than 0.01%): Leucopenia, severe neutropenia, agranulocytosis, hemolytic anemia, thrombocytopenia, bleeding time prolonged, prothrombin time prolonged

Frequency not reported: Anemia, thrombocytopenic purpura, eosinophilia, platelet function defective, lymphadenopathy

Common (1% to 10%): Candidiasis, fungal/mycotic infection

Very rare (less than 0.01%): Mucocutaneous candidiasis

Frequency not reported: Intestinal candidiasis, oral moniliasis, vaginal moniliasis, fever, chills

Very rare (less than 0.01%): Hepatitis, cholestatic jaundice, AST increased, ALT increased

Frequency not reported: Hepatic dysfunction, hepatic cholestasis, acute cytolytic hepatitis

Frequency not reported: Bronchospasm, acute severe dyspnea, pneumonitis allergic

Frequency not reported: Phlebitis, injection site pain

Frequency not reported: Electrolyte disturbance, hypokalemia

Frequency not reported: Joint pain, arthralgia

Frequency not reported: Agitation, anxiety, insomnia, confusion, behavior changed, hallucination