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Commonly reported side effects of amlodipine include: edema. Other side effects include: fatigue, palpitations, and flushing. See below for a comprehensive list of adverse effects.For the Consumer
Applies to amlodipine: oral tablet
Along with its needed effects, amlodipine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking amlodipine:
Incidence not known
Some side effects of amlodipine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
For Healthcare Professionals
Applies to amlodipine: oral suspension, oral tablet, oral tablet disintegratingGeneral
The most commonly reported side effects include headache, edema, rash, fatigue, and dizziness.Cardiovascular
Myocardial infarction, chest pain, and arrhythmia (e.g., bradycardia, ventricular tachycardia, atrial fibrillation) cannot be distinguished from the natural history of the underlying disease.
Edema occurred in 14.6% of female patients given this drug compared to 5.6% of male patients, and was more likely to occur in patients given the 10 mg dose (compared to the 5 and 2.5 mg doses).
Very common (10% or more): Edema (up to 14.6%)
Common (1% to 10%): Palpitations, ankle edema
Uncommon (0.1% to 1%): Hypotension, chest pain
Very rare (less than 0.01%): Myocardial infarction, arrhythmia (including bradycardia, ventricular tachycardia, atrial fibrillation), vasculitis, cardiac failure, pulse irregularity, extrasystoles, hot flush
Frequency not reported: Tachycardia, peripheral ischemia, postural hypotensionNervous system
Common (1% to 10%): Somnolence, dizziness, headache
Uncommon (0.1% to 1%): Tremor, taste perversion/dysgeusia, syncope, hypoesthesia, paresthesia
Very rare (less than 0.01%): Hypertonia, peripheral neuropathy, ataxia, migraine, amnesia, parosmia
Frequency not reported: Extrapyramidal syndrome, postural dizziness, vertigo
Headache occurred commonly during clinical trials, especially at the beginning of treatment.
Extrapyramidal syndrome may be associated with this drug.Gastrointestinal
Common (1% to 10%): Abdominal pain, nausea
Uncommon (0.1% to 1%): Vomiting, dyspepsia, altered bowel habits (including diarrhea and constipation), dry mouth
Very rare (less than 0.01%): Pancreatitis, gastritis, gingival hyperplasia, loose stools
Frequency not reported: Dysphagia, flatulenceDermatologic
Common (1% to 10%): Flushing
Uncommon (0.1% to 1%): Alopecia, skin discoloration, increased sweating/hyperhidrosis, pruritus, rash, exanthema
Very rare (less than 0.01%): Erythema multiforme, urticaria, exfoliative dermatitis, Stevens-Johnson syndrome, Quincke edema, photosensitivity, skin dryness, cold and clammy skin, dermatitisOther
Common (1% to 10%): Fatigue
Uncommon (0.1% to 1%): Tinnitus, asthenia, pain, malaise
Frequency not reported: Rigors, thirstGenitourinary
Uncommon (0.1% to 1%): Micturition disorder, nocturia, increased urinary frequency, impotence
Very rare (less than 0.01%): Dysuria, polyuria
Frequency not reported: Male/female sexual dysfunctionMusculoskeletal
Uncommon (0.1% to 1%): Arthralgia, myalgia, muscle cramps, back pain
Very rare (less than 0.01%): Muscle weakness
Frequency not reported: Arthrosis, twitchingPsychiatric
Uncommon (0.1% to 1%): Insomnia, mood changes (including anxiety), depression
Rare (0.01% to 0.1%): Confusion
Frequency not reported: Abnormal dreams, depersonalization, nervousness, apathy, agitationRespiratory
Uncommon (0.1% to 1%): Dyspnea, rhinitis
Very rare (less than 0.01%): Cough
Frequency not reported: EpistaxisOcular
Uncommon (0.1% to 1%): Visual disturbance (including diplopia)
Very rare (less than 0.01%): Abnormal visual accommodation, xerophthalmia
Frequency not reported: Abnormal vision, conjunctivitis, eye painMetabolic
Uncommon (0.1% to 1%): Weight increase/decrease
Very rare (less than 0.01%): Hyperglycemia, increased appetite
Frequency not reported: AnorexiaHematologic
Uncommon (0.1% to 1%): Purpura
Very rare (less than 0.01%): Leukopenia, thrombocytopeniaEndocrine
Uncommon (0.1% to 1%): GynecomastiaHepatic
Very rare (less than 0.01%): Hepatitis, jaundice, hepatic enzymes increased
Increased hepatic enzymes were mostly consistent with cholestasis.
Some cases of hepatitis, jaundice, and/or hepatic enzyme elevations were severe enough to require hospitalization; however, the association with this drug was uncertain in most cases.Hypersensitivity
Very rare (less than 0.01%): Allergic reactions, angioedema