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Amlodipine is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow.
Amlodipine is used to treat chest pain (angina) and other conditions caused by coronary artery disease.
Amlodipine is also used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.
Amlodipine is for use in adults and children who are at least 6 years old.
Before taking amlodipine, tell your doctor if you have congestive heart failure or liver disease.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of amlodipine.
If you are being treated for high blood pressure, keep using amlodipine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Amlodipine is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.
Tell your doctor about all other heart or blood pressure medications you are taking.
Your chest pain may become worse when you first start taking amlodipine or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.
You should not take amlodipine if you are allergic to it.
To make sure amlodipine is safe for you, tell your doctor if you have ever had:
liver disease; or
a heart valve problem called aortic stenosis.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether amlodipine will harm an unborn baby. However, having high blood pressure during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating hypertension may outweigh any risks to the baby.
Amlodipine can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breast-feeding.
Amlodipine is not approved for use by anyone younger than 6 years old.
Take amlodipine exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
You may take amlodipine with or without food. Take the medicine at the same time each day.
Shake the Katerzia oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
Your blood pressure will need to be checked often.
Your chest pain may become worse when you first start taking amlodipine or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.
If you are being treated for high blood pressure, keep using amlodipine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Your hypertension or heart condition may be treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or stop taking any of your medications without your doctor's advice. This is especially important if you also take nitroglycerin.
Amlodipine is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.
Store at room temperature away from moisture, heat, and light.
Take the missed dose as soon as you remember. If you are more than 12 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include rapid heartbeats, redness or warmth in your arms or legs, or fainting.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Get emergency medical help if you have signs of an allergic reaction to amlodipine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
In rare cases, when you first start taking amlodipine, your angina may get worse or you could have a heart attack. Seek emergency medical attention or call your doctor right away if you have symptoms such as: chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.
Call your doctor at once if you have:
pounding heartbeats or fluttering in your chest;
worsening chest pain;
swelling in your feet or ankles;
severe drowsiness; or
a light-headed feeling, like you might pass out.
Common amlodipine side effects may include:
dizziness, drowsiness;
feeling tired;
stomach pain, nausea; or
flushing (warmth, redness, or tingly feeling).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all your current medicines and any you start or stop using, especially:
nitroglycerin;
simvastatin (Zocor, Simcor, Vytorin); or
any other heart or blood pressure medications.
This list is not complete. Other drugs may interact with amlodipine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use amlodipine only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Amlodipine Besylate (www.drugs.com/amlodipine.html).
Commonly reported side effects of amlodipine include: edema. Other side effects include: fatigue, palpitations, and flushing. See below for a comprehensive list of adverse effects.
Applies to amlodipine: oral tablet
Along with its needed effects, amlodipine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking amlodipine:
More common
Less common
Rare
Incidence not known
Some side effects of amlodipine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Rare
Incidence not known
Applies to amlodipine: oral suspension, oral tablet, oral tablet disintegrating
The most commonly reported side effects include headache, edema, rash, fatigue, and dizziness.
Myocardial infarction, chest pain, and arrhythmia (e.g., bradycardia, ventricular tachycardia, atrial fibrillation) cannot be distinguished from the natural history of the underlying disease.
Edema occurred in 14.6% of female patients given this drug compared to 5.6% of male patients, and was more likely to occur in patients given the 10 mg dose (compared to the 5 and 2.5 mg doses).
Very common (10% or more): Edema (up to 14.6%)
Common (1% to 10%): Palpitations, ankle edema
Uncommon (0.1% to 1%): Hypotension, chest pain
Very rare (less than 0.01%): Myocardial infarction, arrhythmia (including bradycardia, ventricular tachycardia, atrial fibrillation), vasculitis, cardiac failure, pulse irregularity, extrasystoles, hot flush
Frequency not reported: Tachycardia, peripheral ischemia, postural hypotension
Common (1% to 10%): Somnolence, dizziness, headache
Uncommon (0.1% to 1%): Tremor, taste perversion/dysgeusia, syncope, hypoesthesia, paresthesia
Very rare (less than 0.01%): Hypertonia, peripheral neuropathy, ataxia, migraine, amnesia, parosmia
Frequency not reported: Extrapyramidal syndrome, postural dizziness, vertigo
Headache occurred commonly during clinical trials, especially at the beginning of treatment.
Extrapyramidal syndrome may be associated with this drug.
Common (1% to 10%): Abdominal pain, nausea
Uncommon (0.1% to 1%): Vomiting, dyspepsia, altered bowel habits (including diarrhea and constipation), dry mouth
Very rare (less than 0.01%): Pancreatitis, gastritis, gingival hyperplasia, loose stools
Frequency not reported: Dysphagia, flatulence
Common (1% to 10%): Flushing
Uncommon (0.1% to 1%): Alopecia, skin discoloration, increased sweating/hyperhidrosis, pruritus, rash, exanthema
Very rare (less than 0.01%): Erythema multiforme, urticaria, exfoliative dermatitis, Stevens-Johnson syndrome, Quincke edema, photosensitivity, skin dryness, cold and clammy skin, dermatitis
Common (1% to 10%): Fatigue
Uncommon (0.1% to 1%): Tinnitus, asthenia, pain, malaise
Frequency not reported: Rigors, thirst
Uncommon (0.1% to 1%): Micturition disorder, nocturia, increased urinary frequency, impotence
Very rare (less than 0.01%): Dysuria, polyuria
Frequency not reported: Male/female sexual dysfunction
Uncommon (0.1% to 1%): Arthralgia, myalgia, muscle cramps, back pain
Very rare (less than 0.01%): Muscle weakness
Frequency not reported: Arthrosis, twitching
Uncommon (0.1% to 1%): Insomnia, mood changes (including anxiety), depression
Rare (0.01% to 0.1%): Confusion
Frequency not reported: Abnormal dreams, depersonalization, nervousness, apathy, agitation
Uncommon (0.1% to 1%): Dyspnea, rhinitis
Very rare (less than 0.01%): Cough
Frequency not reported: Epistaxis
Uncommon (0.1% to 1%): Visual disturbance (including diplopia)
Very rare (less than 0.01%): Abnormal visual accommodation, xerophthalmia
Frequency not reported: Abnormal vision, conjunctivitis, eye pain
Uncommon (0.1% to 1%): Weight increase/decrease
Very rare (less than 0.01%): Hyperglycemia, increased appetite
Frequency not reported: Anorexia
Uncommon (0.1% to 1%): Purpura
Very rare (less than 0.01%): Leukopenia, thrombocytopenia
Uncommon (0.1% to 1%): Gynecomastia
Very rare (less than 0.01%): Hepatitis, jaundice, hepatic enzymes increased
Increased hepatic enzymes were mostly consistent with cholestasis.
Some cases of hepatitis, jaundice, and/or hepatic enzyme elevations were severe enough to require hospitalization; however, the association with this drug was uncertain in most cases.
Very rare (less than 0.01%): Allergic reactions, angioedema
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Amlodipine Besylate (www.drugs.com/amlodipine.html).
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