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Amikacin Sulfate

Amikacin sulfate Prescription
Generic Name: amikacin liposome (AM i KAY sin)
Brand Name: Arikayce
Physician reviewed amikacin liposome patient information - includes amikacin liposome description, dosage and directions.
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Amikacin Sulfate Drug Information:

Amikacin liposome is an antibiotic that is used to treat Mycobacterium avium complex (MAC) lung disease in adults who have few or no other treatment options. Amikacin liposome is given in combination with other antibiotics. Amikacin liposome is given only to certain adults, when other antibiotics have failed to clear their MAC infections after 6 months of treatment. Amikacin liposome was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to amikacin liposome, but further studies are needed. Learn more

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Amikacin Sulfate Side Effects

For the Consumer

Applies to amikacin liposome: inhalation suspension


Inhalation route (Suspension)

Amikacin liposome has been associated with an increased risk of respiratory adverse reactions, including, hypersensitivity pneumonitis, hemoptysis, bronchospasm, and exacerbation of underlying pulmonary disease that have led to hospitalizations in some cases.

Side effects requiring immediate medical attention

Along with its needed effects, amikacin liposome may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amikacin liposome:

More common

  • Cough
  • coughing or spitting up blood
  • difficulty breathing
  • dizziness
  • feeling of fullness in the ears
  • fever
  • loss of balance
  • loss of hearing
  • noisy breathing
  • ringing or buzzing in the ears
  • sore throat
  • tightness in the chest
  • trouble hearing
  • upper airway irritation
  • voice changes

Less common

  • Balance disorder
  • blue lips, fingernails, or skin
  • change in sputum
  • chest discomfort or pain
  • chills
  • cough producing mucus
  • general feeling of discomfort or illness
  • irregular, fast or slow, or shallow breathing
  • nosebleed
  • severe pain in the chest
  • sudden onset of severe breathing difficulty
  • thickening of bronchial secretions
Side effects not requiring immediate medical attention

Some side effects of amikacin liposome may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bone or muscle pain
  • decreased weight
  • diarrhea
  • headache
  • lack or loss of strength
  • nausea
  • rash
  • unusual tiredness or weakness
  • vomiting

Less common

  • Anxiety
  • change in taste
  • dry mouth
  • loss of taste

For Healthcare Professionals

Applies to amikacin liposome: inhalation suspension


The most commonly reported side effects included dysphonia, cough, bronchospasm, and hemoptysis.


Very common (10% or more): Dysphonia (up to 47%), cough (up to 39%), bronchospasm (up to 29%), hemoptysis (up to 18%), upper airway irritation (up to 17%), exacerbation of underlying pulmonary disease (up to 15%)

Common (1% to 10%): Bronchitis, change in sputum, epistaxis, hypersensitivity pneumonitis, pneumonia, pneumothorax, respiratory failure

Frequency not reported: Acute respiratory failure, allergic alveolitis, aspiration pneumonia, asthma, atypical pneumonia, bronchial hyperreactivity, chronic obstructive pulmonary disease (COPD) exacerbation, dyspnea, dyspnea exertional, increased sputum, infective exacerbation of bronchiectasis, infective exacerbation of COPD, interstitial lung disease, laryngeal erythema, laryngeal pain, laryngitis, lower respiratory tract infection, lung infection, lung infection pseudomonas, oropharyngeal discomfort, oropharyngeal pain, pharyngeal edema, pharyngeal erythema, pleural effusion infection, productive cough, pneumomediastinum, pneumonia pseudomonas, pneumonitis, prolonged expiration, respiratory tract infection, spontaneous pneumothorax, sputum discolored, throat irritation, throat tightness, upper airway cough syndrome, upper airway inflammation, vocal cord inflammation, wheezing


Very common (10% or more): Ototoxicity (up to 17%), asthenia (up to 16%), fatigue (up to 16%)

Common (1% to 10%): Chest discomfort, exercise tolerance decreased, pyrexia

Frequency not reported: Body ache, deafness, exacerbation of underlying disease, hypoacusis, neurosensory deafness, pain, tinnitus, unilateral deafness


Very common (10% or more): Diarrhea (up to 13%), nausea (up to 12%)

Common (1% to 10%): Dry mouth, oral fungal infection, vomiting

Frequency not reported: Oral candidiasis, post-tussive vomiting


Very common (10% or more): Musculoskeletal pain (up to 17%)

Frequency not reported: Arthralgia, back pain, muscle spasm, muscle weakness, myalgia

Nervous system

Common (1% to 10%): Balance disorder, dysgeusia, headache, neuromuscular disorder

Frequency not reported: Aphonia, dizziness, neuromuscular blockade, peripheral neuropathy, presyncope, vertigo


Common (1% to 10%): Rash

Frequency not reported: Drug eruption, maculopapular rash, urticaria


Common (1% to 10%): Anxiety


Common (1% to 10%): Decreased weight


Frequency not reported: Empyema, pseudomonas infection, sputum purulent


Frequency not reported: Nephrotoxicity

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Amikacin Sulfate (www.drugs.com/mtm/amikacin-liposome.html).