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Ambisome

Generic Name: amphotericin B liposomal (AM foe TER i sin B LYE poe SOE mal)
Brand Names: AmBisome
Ambisome (amphotericin B) is used to treat serious, life-threatening fungal infections, including a certain form of meningitis. Includes Ambisome side effects, interactions and indications.
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Drug Information:
AmBisome (amphotericin B lipoSomal) is an antifungal medication that fights infections caused by fungus. AmBisome is used to treat serious, life-threatening fungal infections including leishmaniasis, or a certain form of meningitis in people infected with HIV (human immunodeficiency virus). AmBisome is not for treating a minor fungal infection such as a yeast infection of the mouth, esophagus, or vagina. AmBisome may need to be given for up to several weeks or months, depending on the infection being treated. Learn more

Ambisome Side Effects

AmBisome Side Effects

Note: This document contains side effect information about amphotericin b liposomal. Some of the dosage forms listed on this page may not apply to the brand name AmBisome.

For the Consumer

Applies to amphotericin b liposomal: intravenous powder for solution

Along with its needed effects, amphotericin b liposomal (the active ingredient contained in AmBisome) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking amphotericin b liposomal:

More common

  • Chills
  • fever
  • irregular heartbeat
  • muscle cramps or pain
  • unusual tiredness or weakness

Less common

  • Back pain
  • chest pain
  • dark urine
  • difficulty in breathing
  • headache
  • yellowing of eyes or skin

Rare

  • Difficulty in swallowing
  • hives
  • itching, especially of feet or hands
  • reddening of skin, especially around ears
  • swelling of eyes, face, or inside of nose
  • unusual tiredness or weakness (sudden and severe)

Some side effects of amphotericin b liposomal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal pain
  • cough
  • diarrhea
  • dizziness
  • nausea
  • vomiting

Less common

  • Skin rash

For Healthcare Professionals

Applies to amphotericin b liposomal: intravenous powder for injection

Metabolic

Very common (10% or more): Hypokalemia (51.1%), hyperglycemia (23%), hypomagnesemia (25.9%), hypocalcemia (18.4%), anorexia (14%), hypervolemia (12.2%), hyponatremia (11.6%)

Common (1% to 10%): Hypernatremia, fluid overload, acidosis, hyperchloremia, hyperkalemia, hypermagnesemia, hyperphosphatemia, hypoproteinemia, nonprotein nitrogen (NPN) increased, hyperglycemia

Renal

Very common (10% or more): Creatinine increased (22.4%), BUN increased (21%)

Common (1% to 10%): Abnormal renal function, acute kidney failure, acute renal failure, kidney failure, toxic nephropathy, increased blood urea

Frequency not reported: Renal insufficiency

Hematologic

Very common (10% or more): Anemia (47.9%), leukopenia (15.1%), thrombocytopenia (12.8%)

Common (1% to 10%): Coagulation disorder, ecchymosis, prothrombin decreased, prothrombin increased, thrombocytopenia

Postmarketing reports: Agranulocytosis

Cardiovascular

Very common (10% or more): Hypertension (19.8%), hypotension (14.3%), chest pain (11.1%), phlebitis (10.6%)

Common (1% to 10%): Vasodilatation, arrhythmia, atrial fibrillation, bradycardia, cardiac arrest, cardiomegaly, hemorrhage, postural hypotension, valvular heart disease, vascular disorder

Respiratory

Very common (10% or more): Dyspnea (23%), cough increased (17.8%), lung disorder (17.8%), epistaxis (14.9%), pleural effusion (12.5%), rhinitis (11.1%)

Common (1% to 10%): Hypoxia, hyperventilation, respiratory alkalosis, cough, asthma, atelectasis, hemoptysis, hiccup, hyperventilation, lung edema, pharyngitis, pneumonia, respiratory insufficiency, respiratory failure, sinusitis

Uncommon (0.1% to 1%): Hypoxia

Postmarketing reports: Bronchospasm, cyanosis/hypoventilation, pulmonary edema

Gastrointestinal

Very common (10% or more): Nausea (39.7%), vomiting (31.8%), diarrhea (30.3%), abdominal pain (19.8%), constipation (15.1%)

Common (1% to 10%): Gastrointestinal hemorrhage, dry mouth/nose, dyspepsia, eructation, flatulence, fecal incontinence, hemorrhoids, gum/oral hemorrhage, hematemesis, ileus, mucositis, rectal disorder, stomatitis, ulcerative stomatitis, amylase increased

Other

Very common (10% or more): Fever (89.5%), blood product transfusion reaction (18.4%), peripheral edema (14.6%), edema (14.3%), pain (14%), asthenia (13.1%), chest pain (12%), pyrexia

Common (1% to 10%): Procedural complication, abdomen enlarged, malaise, neck pain, lactate dehydrogenase increased, rigors, influenza-like illness, herpes simplex

Nervous system

Very common (10% or more): Headache (19.8%)

Common (1% to 10%): Dizziness, dystonia, coma, convulsion, dysesthesia, dizziness, paresthesia, somnolence, tremor

Hepatic

Very common (10% or more): Alkaline phosphatase increased (22.2%), bilirubinemia (18.1%), ALT (SGPT) increased (14.6%), AST (SGOT) increased (12.8%), liver function tests abnormal (12.8%)

Common (1% to 10%): Hepatocellular damage, hepatomegaly, veno-occlusive liver disease

Dermatologic

Very common (10% or more): Rash (24.8%), pruritus (10.8%)

Common (1% to 10%): Sweating, cellulitis, face edema, petechia, alopecia, dry skin, maculopapular rash, purpura, skin discoloration, skin disorder, skin ulcer, vesiculobullous rash, flushing

Frequency not reported: Angioneurotic edema

Postmarketing reports: Angioedema, erythema, urticaria

Genitourinary

Very common (10% or more): Hematuria (14%)

Common (1% to 10%): Dysuria, urinary incontinence, vaginal hemorrhage

Postmarketing reports: Hemorrhagic cystitis

Psychiatric

Very common (10% or more): Insomnia (22.1%), anxiety (13.7%), confusion (12.9%)

Common (1% to 10%): Agitation, depression, hallucinations, nervousness, thinking abnormality

Immunologic

Very common (10% or more): Sepsis (14%), infection (12.8%)

Common (1% to 10%): Cell mediated immunologic reaction

Musculoskeletal

Very common (10% or more): Chills (48.1%), back pain (12%)

Common (1% to 10%): Arthralgia, bone pain, myalgia

Postmarketing reports: Rhabdomyolysis

Hypersensitivity

Common (1% to 10%): Allergic reaction

Uncommon (0.1% to 1%): Anaphylactoid reaction

Frequency not reported: Anaphylactic reactions, hypersensitivity

Ocular

Common (1% to 10%): Conjunctivitis, dry eyes, eye hemorrhage

Local

Common (1% to 10%): Injection site inflammation

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Ambisome (www.drugs.com/ambisome.html).