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Altace (ramipril) is an ACE inhibitor. ACE stands for angiotensin converting enzyme.
Altace is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack.
Altace is also used to treat congestive heart failure.
Do not Altace use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.
You should not use Altace if you have ever had angioedema. Do not take ramipril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use ramipril together with any medication that contains aliskiren (a blood pressure medicine).
You should not use Altace if you are allergic to ramipril, or if:
you recently took a heart medicine called sacubitril; or
you have ever had a severe allergic reaction to any ACE inhibitor (benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, or trandolapril).
Do not take Altace within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use ramipril together with any medication that contains aliskiren (a blood pressure medicine).
You may also need to avoid taking ramipril with aliskiren if you have kidney disease.
To make sure Altace is safe for you, tell your doctor if you have ever had:
kidney disease (or if you are on dialysis);
an electrolyte imbalance (such as high levels of potassium in your blood);
liver disease;
a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis;
if you are on a low-salt diet; or
if you are also taking telmisartan (Micardis).
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Altace can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
You should not breast-feed while you are using ramipril.
Altace is not approved for use by anyone younger than 18 years old.
Take Altace exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Swallow the tablet whole.
Your blood pressure will need to be checked often, and you may need blood tests.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking Altace. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.
If you need surgery, tell the surgeon ahead of time that you are using ramipril.
If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
Usual Adult Dose for Diabetic Nephropathy:
Initial dose: 2.5 mg orally once a day for patients not receiving a diuretic
Maintenance dose: 2.5 to 20 mg/day orally in 1 to 2 divided doses
Usual Adult Dose for Hypertension:
Initial dose: 2.5 mg orally once a day for patients not receiving a diuretic
Maintenance dose: 2.5 to 20 mg/day orally in 1 to 2 divided doses
Usual Adult Dose for Congestive Heart Failure:
Initial dose: 2.5 mg orally twice a day
Maintenance dose: 5 mg orally twice a day
Usual Adult Dose for Left Ventricular Dysfunction:
Initial dose: 2.5 mg orally twice a day
Maintenance dose: 5 mg orally twice a day
Usual Adult Dose for Myocardial Infarction:
Initial dose: 2.5 mg orally twice a day
Maintenance dose: 5 mg orally twice a day
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Do not use potassium supplements or salt substitutes, unless your doctor has told you to.
Get emergency medical help if you have signs of an allergic reaction to Altace: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
jaundice (yellowing of your skin or eyes);
little or no urination;
fever, chills, sore throat; or
high potassium - nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement.
Common Altace side effects may include:
headache;
cough; or
dizziness, weakness, tired feeling.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all your current medicines. Many drugs can interact with Altace, especially:
a diuretic ("water pill"), or any other blood pressure medications;
lithium;
gold injections to treat arthritis;
insulin or oral diabetes medicine; or
NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete and many other drugs may interact with Altace. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Altace only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Altace (www.drugs.com/altace.html).
Note: This document contains side effect information about ramipril. Some of the dosage forms listed on this page may not apply to the brand name Altace.
Common side effects of Altace include: hypotension and increased cough. See below for a comprehensive list of adverse effects.
Applies to ramipril: oral capsule
Oral route (Capsule; Tablet)
When pregnancy is detected, discontinue ramipril as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
Along with its needed effects, ramipril (the active ingredient contained in Altace) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ramipril:
More common
Less common
Rare
Some side effects of ramipril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Rare
Applies to ramipril: oral capsule, oral tablet
The most common adverse reaction is hypotension.
Very common (10% or more): Hypotension (11%)
Common (1% to 10%): Angina pectoris, postural hypotension, orthostatic blood pressure decreased
Uncommon (0.1% to 1%): Symptomatic hypotension, myocardial ischemia, myocardial infarction, tachycardia, arrhythmia, palpitation, flushing
Rare (less than 0.1%): Vascular stenosis, hypoperfusion, vasculitis
Frequency not reported: Disturbed orthostatic regulation, Raynaud's phenomenon
Common (1% to 10%): Nausea, vomiting, diarrhea, gastrointestinal inflammation, digestive disturbances, abdominal discomfort, dyspepsia
Uncommon (0.1% to 1%): Pancreatitis, pancreatic enzymes increased, abdominal pain, small bowel angioedema, gastritis, constipation, dry mouth
Rare (less than 0.1%): Glossitis
Frequency not reported: Dysphagia, gastroenteritis, increased salivation, gastric pain, aphthous stomatitis
Common (1% to 10%): Fatigue, asthenia, vertigo, bronchitis, sinusitis, chest pain
Uncommon (0.1% to 1%): Peripheral edema, pyrexia, libido decreased
Rare (less than 0.1%): Conjunctivitis, hearing impaired, tinnitus
Frequency not reported: Hearing loss, edema, malaise, gynecomastia
Common (1% to 10%): Cough, nonproductive tickling cough, cough increased, dyspnea
Uncommon (0.1% to 1%): Bronchospasm, asthma aggravated
Frequency not reported: Eosinophilic pneumonitis, epistaxis, nasal congestion
Uncommon (0.1% to 1%): Depressed mood, anxiety, nervousness, restlessness, sleep disorder
Rare (less than 0.1%): Confusional state
Frequency not reported: Depression, insomnia, disturbance in attention
Common (1% to 10%): Headache, dizziness, syncope
Uncommon (0.1% to 1%): Paresthesia, dysgeusia, ageusia, somnolence
Rare (less than 0.1%): Tremor, balance disorder
Frequency not reported: Smell disturbance, amnesia, convulsions, neuralgia, neuropathy, cerebral ischemia, ischemic stroke, transient ischemic attack, psychomotor skills impaired, burning sensation, parosmia
Common (1% to 10%): Muscle spasm, myalgia
Uncommon (0.1% to 1%): Arthralgia
Frequency not reported: Arthritis
Common (1% to 10%): Maculopapular rash
Uncommon (0.1% to 1%): Pruritus, hyperhidrosis
Rare (less than 0.1%): Exfoliative dermatitis, urticaria, onycholysis
Frequency not reported: Purpura, pemphigus, pemphigoid, erythema multiforme, toxic epidermal necrolysis, Stevens Johnson syndrome, sweating increased, alopecia, psoriasis aggravated, dermatitis psoriasiform, lichenoid exanthema, enanthema
Common (1% to 10%): Abnormal kidney function
Uncommon (0.1% to 1%): Renal impairment, acute renal failure
Common (1% to 10%): Creatinine increased, blood potassium increased
Uncommon (0.1% to 1%): Anorexia, decreased appetite, BUN increased
Frequency not reported: Weight gain, hyponatremia, loss of appetite, uric acid elevated, blood glucose elevated, blood sodium decreased
Postmarketing reports: Hypoglycemia
Uncommon (0.1% to 1%): Worsening of preexisting proteinuria, urine output increased, transient erectile impotence
Frequency not reported: Proteinuria, impotence
Uncommon (0.1% to 1%): Visual disturbance, blurred vision
Uncommon (0.1% to 1%): Eosinophilia, hemoglobin or hematocrit decreased
Rare (less than 0.1%): Neutropenia, agranulocytosis, white blood cell count decreased, red blood cell count decreased, platelet count decreased
Frequency not reported: Pancytopenia, hemolytic anemia, thrombocytopenia, leucopenia, bone marrow failure
Uncommon (0.1% to 1%): Hepatic enzymes increased, conjugated bilirubin increased
Rare (less than 0.1%): Cholestatic jaundice, hepatocellular damage
Frequency not reported: Hepatic failure, hepatitis, jaundice, acute liver failure, hepatocellular damage, cholestatic hepatitis, cytolytic hepatitis, serum bilirubin elevated
Uncommon (0.1% to 1%): Angioneurotic edema, angioedema
Very rare (less than 0.01%): Photosensitivity
Frequency not reported: Anaphylactic reaction, anaphylactoid reaction, apparent hypersensitivity reaction, antinuclear antibody increased
Frequency not reported: Syndrome of inappropriate antidiuretic hormone secretion
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Altace (www.drugs.com/altace.html).
March 28, 2020
March 28, 2020
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