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Aloxi Prescription
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Generic Name: palonosetron (injection) (PAL oh NOE se tron)
Brand Names: Aloxi
Aloxi (palonosetron) is used to prevent nausea and vomiting caused by surgery or chemotherapy treatment. Includes Aloxi side effects, interactions and indications.
Generic Name: palonosetron (injection) (PAL oh NOE se tron)
Brand Names: Aloxi
Aloxi (palonosetron) is used to prevent nausea and vomiting caused by surgery or chemotherapy treatment. Includes Aloxi side effects, interactions and indications.
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1 tablets of Aloxi 40 mg
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Aloxi Drug Information:

Aloxi (palonosetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting. Aloxi is used in adults to prevent nausea and vomiting caused by surgery, or by receiving medicine to treat cancer (chemotherapy). Aloxi is used in children as young as 1 month old only to prevent nausea and vomiting caused by cancer medicine. Before you receive Aloxi, tell your doctor about all your medical conditions or allergies, and all the medicines you are using. Also make sure your doctor knows if you are pregnant or breast-feeding. Learn more

Aloxi Side Effects

Note: This document contains side effect information about palonosetron. Some of the dosage forms listed on this page may not apply to the brand name Aloxi.

For the Consumer

Applies to palonosetron: intravenous solution

Along with its needed effects, palonosetron (the active ingredient contained in Aloxi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking palonosetron:

Less common

  • Blurred vision
  • chest pain or discomfort
  • confusion
  • difficult breathing
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • fainting
  • fever
  • irregular heartbeats that continue
  • sweating
  • unusual tiredness or weakness


  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • extra heartbeats
  • nervousness
  • pain in the shoulders, arms, jaw, or neck
  • pounding in the ears
  • slow or fast heartbeat

Incidence not known

  • Agitation
  • diarrhea
  • overactive reflexes
  • poor coordination
  • restlessness
  • shivering
  • talking or acting with excitement you cannot control
  • trembling or shaking
  • twitching

Get emergency help immediately if any of the following symptoms of overdose occur while taking palonosetron:

Symptoms of overdose

  • Bluish color of the fingernails, lips, skin, palms, or nail beds
  • collapse
  • gasping to breathe
  • paleness of the skin
  • seizures

Some side effects of palonosetron may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty having a bowel movement (stool)
  • headache

Less common

  • Acid or sour stomach
  • belching
  • bloated or full feeling
  • blood in the urine
  • bloody or black, tarry stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in vision
  • chills
  • continuing ringing or buzzing
  • cough
  • decrease in frequency of urination
  • decrease in urine volume
  • deep breathing
  • difficulty in passing urine
  • drowsiness
  • dry mouth
  • excess air or gas in the stomach or intestines
  • excessive sleeping
  • eye irritation
  • fear
  • feeling happy
  • feeling of warmth
  • flushed dry skin
  • fruit-like breath odor
  • general feeling of discomfort or illness
  • hearing loss
  • heartburn
  • hiccups
  • impaired vision
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • joint pain
  • large, flat, blue or purplish patches in the skin
  • loss of appetite
  • muscle aches and pains
  • muscle tremors
  • numbness or tingling in the hands, feet, or lips
  • painful knees and ankles
  • painful urination
  • passing gas
  • raised red swellings on the skin, the buttocks, legs or ankles
  • rash
  • red, sore eyes
  • redness of the face, neck, arms, and occasionally, upper chest
  • runny nose
  • sore throat
  • stomach discomfort, upset, or pain
  • sugar in the urine
  • swelling or protruding veins
  • trouble sleeping
  • unexplained noise in the ears
  • unexplained weight loss
  • unusually deep sleep
  • unusually long duration of sleep
  • vein discoloration
  • weakness or heaviness of the legs

For Healthcare Professionals

Applies to palonosetron: intravenous solution, oral capsule


The most commonly reported side effects included headache, constipation, diarrhea, and dizziness.


Common (1% to 10%): Bradycardia/sinus bradycardia, electrocardiogram QTc prolongation, hypotension, nonsustained tachycardia/tachycardia

Uncommon (0.1% to 1%): Atrioventricular (AV) block first degree, AV block second degree, conduction disorder, extrasystoles, hypertension, myocardial ischemia, sinus arrhythmia, sinus tachycardia, supraventricular extrasystoles, vein discoloration, vein distended

Frequency not reported: Arrhythmia, blood pressure decreased, ECG T wave amplitude decreased, generalized edema, hot flash, ventricular extrasystoles

Postmarketing reports: Shock


Common (1% to 10%): Constipation, diarrhea, flatulence

Uncommon (0.1% to 1%): Abdominal pain, abdominal pain upper, dry mouth, dyspepsia, nausea

Frequency not reported: Intestinal hypomobility, salivary hypersecretion


Common (1% to 10%): Asthenia, weakness

Uncommon (0.1% to 1%): Fatigue, feeling hot, motion sickness, pain, pyrexia, tinnitus

Frequency not reported: Chills, fever

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Dyskinesia, hypersomnia, paresthesia, peripheral sensory neuropathy, somnolence


Common (1% to 10%): Increased ALT, increased AST

Uncommon (0.1% to 1%): Blood bilirubin increased, elevated transaminases, hyperbilirubinemia

Frequency not reported: Hepatic enzymes increased, transient, asymptomatic increases in AST and/or ALT and bilirubin


Common (1% to 10%): Hyperkalemia

Uncommon (0.1% to 1%): Anorexia, appetite decreased, hyperglycemia, hypocalcemia, hypokalemia, metabolic disorders

Frequency not reported: Electrolyte fluctuations, metabolic acidosis


Common (1% to 10%): Pruritus

Uncommon (0.1% to 1%): Allergic dermatitis, pruritic rash, skin disorder, urticaria


Common (1% to 10%): Anxiety

Uncommon (0.1% to 1%): Euphoric mood, insomnia


Common (1% to 10%): Urinary retention

Uncommon (0.1% to 1%): Glycosuria


Uncommon (0.1% to 1%): Cough, dyspnea, epistaxis, hiccups

Frequency not reported: Hypoventilation, laryngospasm


Uncommon (0.1% to 1%): Amblyopia, eye irritation, eye swelling


Uncommon (0.1% to 1%): Infusion site pain, infusion site reaction

Very rare (less than 0.01%): Injection site reaction

Frequency not reported: Injection site burning, injection site discomfort, injection site induration, injection site pain


Uncommon (0.1% to 1%): Arthralgia, myalgia


Very rare (less than 0.01%): Hypersensitivity reactions

Frequency not reported: Anaphylactic shock, anaphylaxis


Frequency not reported: Platelet count decreased


Uncommon (0.1% to 1%): Influenza-like illness

Frequency not reported: Flu-like syndrome

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Aloxi (www.drugs.com/aloxi.html).