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Alendronate sodium

Generic Name: Alendronate Tablets (a LEN droe nate)
Brand Name: Fosamax
Easy-to-read patient leaflet for Alendronate Tablets. Includes indications, proper use, special instructions, precautions, and possible side effects.

Average Savings for alendronate sodium (brand): 62.95%

Average Savings for alendronate sodium (generic): 62.95%
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Drug Information:
This is not a list of all drugs or health problems that interact with this medicine (alendronate tablets). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (alendronate tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use this medicine (alendronate tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

Alendronate sodium Side Effects

Alendronate Side Effects

In Summary

Commonly reported side effects of alendronate include: decreased serum calcium and decreased serum phosphate. Other side effects include: arthralgia, myalgia, and ostealgia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to alendronate: oral solution, oral tablet, oral tablet effervescent

Along with its needed effects, alendronate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking alendronate:

More common

  • Abdominal or stomach pain

Less common

  • Difficulty with swallowing
  • heartburn
  • irritation or pain of the esophagus
  • muscle pain

Rare

  • Skin rash

Incidence not known

  • Abdominal or stomach cramps
  • blistering, peeling, or loosening of the skin
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bone, joint, or muscle pain, severe and occasionally incapacitating
  • chest pain
  • chills
  • confusion
  • convulsions
  • cough
  • diarrhea
  • difficulty with breathing
  • difficulty with moving
  • heartburn
  • heavy jaw feeling
  • hives or welts
  • irregular heartbeats
  • itching
  • joint pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loosening of a tooth
  • muscle aching or cramping
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth, fingertips, or feet
  • pain or burning in the throat
  • pain, swelling, or numbness in the mouth or jaw
  • rapid weight gain
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
  • swollen joints
  • tingling of the hands or feet
  • tremor
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • vomiting

Some side effects of alendronate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Constipation
  • diarrhea
  • full or bloated feeling
  • gas
  • headache
  • nausea

Incidence not known

  • Blurred vision or other change in vision
  • dizziness or lightheadedness
  • eye pain
  • feeling of constant movement of self or surroundings
  • general feeling of discomfort or illness
  • hair loss or thinning of the hair
  • sensation of spinning
  • sensitivity of the eye to light
  • tearing

For Healthcare Professionals

Applies to alendronate: oral solution, oral tablet, oral tablet effervescent

General

Generally, this drug has been well tolerated. Adverse effects usually have been mild when patients adhered to prescribing instructions.

Musculoskeletal

Very common (10% or more): Bone, muscle or joint pain (sometimes severe)

Common (1% to 10%): Muscle cramp, joint swelling

Rare (less than 0.1%): Osteonecrosis of the jaw, atypical subtrochanteric and diaphyseal femoral fractures

Postmarketing reports: Myalgia, low-energy femoral shaft and subtrochanteric fractures

Dermatologic

Common (1% to 10%): Alopecia, pruritus

Uncommon (0.1% to 1%): Rash, erythema

Rare (less than 0.1%): Rash with photosensitivity, severe skin reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis

Gastrointestinal

Common (1% to 10%): Abdominal pain, dyspepsia, acid regurgitation, nausea, abdominal distension, constipation, diarrhea, flatulence, esophageal ulcer, gastritis, gastroesophageal reflux

Uncommon (0.1% to 1%): Gastric ulcer, esophagitis, esophageal erosions, melena, dysphagia, vomiting

Rare (less than 0.1%): Esophageal stricture, oropharyngeal ulceration, upper gastrointestinal PUB (perforation, ulcers, bleeding)

Postmarketing reports: Localized osteonecrosis of the jaw, generally associated with tooth extraction and/or local infection with delayed healing

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Dysgeusia

Other

Common (1% to 10%): Vertigo, asthenia, peripheral edema

Uncommon (0.1% to 1%): Transient symptoms of myalgia, malaise and rarely, typically in association with initiation of treatment

Ocular

Uncommon (0.1% to 1%): Eye inflammation (uveitis, scleritis, episcleritis)

Metabolic

Rare (less than 0.1%): Symptomatic hypocalcemia (often in association with predisposing conditions)

Hypersensitivity

Rare (less than 0.1%): Urticaria, angioedema

Respiratory

Postmarketing reports: Acute asthma exacerbations

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Alendronate Sodium (www.drugs.com/alendronate.html).