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Agrylin

Generic Name: anagrelide (an AH gre lide)
Brand Name: Agrylin
Physician reviewed Agrylin patient information - includes Agrylin description, dosage and directions.
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Drug Information:
Agrylin is used to treat a blood cell disorder called thrombocythemia (also called thrombocytosis), which occurs when your body produces too many platelet cells. Agrylin may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. You should not use Agrylin if you are allergic to it. Tell your doctor if you have ever had: bleeding problems; Learn more

Agrylin Side Effects

Agrylin Side Effects

Note: This document contains side effect information about anagrelide. Some of the dosage forms listed on this page may not apply to the brand name Agrylin.

In Summary

Common side effects of Agrylin include: abdominal pain, dizziness, headache, nausea, and palpitations. Other side effects include: back pain, fever, tachycardia, vomiting, and anorexia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to anagrelide: oral capsule

Along with its needed effects, anagrelide (the active ingredient contained in Agrylin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking anagrelide:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • body aches or pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • congestion
  • cough
  • difficult or labored breathing
  • dryness or soreness of the throat
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • hoarseness
  • rapid weight gain
  • runny nose
  • tender, swollen glands in the neck
  • tightness in the chest
  • trouble with swallowing
  • voice changes

Less common

  • Anxiety
  • blurred vision
  • burning feeling while urinating
  • chills
  • cold sweats
  • confusion
  • decreased urine output
  • dehydration
  • difficult or painful urination
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme tiredness or weakness
  • general feeling of discomfort or illness
  • headache
  • irregular breathing
  • joint pain
  • large, flat, blue, or purplish patches on the skin
  • loss of appetite
  • muscle aches and pains
  • nausea
  • noisy breathing
  • pale skin
  • redness of the face, neck, arms, and occasionally, upper chest
  • severe pain or pressure in the chest or the jaw, neck, back, or arms
  • sudden severe headache or weakness
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • trouble sleeping
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • vomiting of blood or material that looks like coffee grounds
  • weight gain

Incidence not known

  • Clay-colored stools
  • dark urine
  • decreased appetite
  • dry cough
  • general feeling of tiredness or weakness
  • rapid breathing
  • skin rash or itching
  • stomach pain or tenderness
  • yellow eyes or skin

Some side effects of anagrelide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • belching
  • diarrhea
  • excess air or gas in the stomach or bowels
  • full feeling
  • heartburn
  • hives or welts
  • indigestion
  • lack or loss of strength
  • pain
  • passing gas
  • stomach discomfort, upset, or pain

Less common

  • Burning feeling in the chest or stomach
  • change in vision
  • constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • depression
  • difficulty with moving
  • double vision
  • hair loss or thinning of the hair
  • hearing loss
  • impaired vision
  • increased sensitivity of the skin to sunlight
  • leg cramps
  • loss of memory
  • muscle pain or stiffness
  • problems with memory
  • redness or other discoloration of the skin
  • seeing double
  • severe sunburn
  • sleepiness or unusual drowsiness
  • stuffy nose
  • swelling or inflammation of the mouth
  • swollen joints

For Healthcare Professionals

Applies to anagrelide: oral capsule

Nervous system

Very common (10% or more): Headache (43.5%), asthenia (23.1%), dizziness (15.4%), pain (15%)

Common (1% to 10%): Fever

Frequency not reported: Migraine, syncope, somnolence, confusion, insomnia, nervousness, amnesia

Cardiovascular

Very common (10% or more): Palpitations (26.1%)

Common (1% to 10%): Chest pain, tachycardia

Frequency not reported: Arrhythmia, cardiovascular disease, angina pectoris, heart failure, postural hypotension, thrombosis, vasodilation

Postmarketing reports: Torsades de pointes, ventricular tachycardia

Gastrointestinal

Very common (10% or more): Diarrhea (25.7%), nausea (17.1%), abdominal pain (16.4%), flatulence (10.2%)

Common (1% to 10%): Vomiting, anorexia, dyspepsia, constipation, gastritis, aphthous stomatitis, pharyngitis, hemorrhage, eructation, dehydration

General

Very common (10% or more): Edema (20.6%)

Common (1% to 10%): Peripheral edema

Frequency not reported: Tinnitus, flu symptoms, chills

Hematologic

Frequency not reported: Anemia, thrombocytopenia, ecchymosis, lymphadenopathy

Hepatic

Very rare (less than 0.01%): Cholestatic liver failure

Frequency not reported: Elevated liver enzymes

Musculoskeletal

Common (1% to 10%): Back pain

Frequency not reported: Arthralgia, myalgia, leg cramps

Respiratory

Very common (10% or more): Dyspnea (11.9%)

Frequency not reported: Pharyngitis, cough, rhinitis, epistaxis, respiratory disease, sinusitis, pneumonia, bronchitis, pleural effusion, pulmonary hypertension, pulmonary infiltrates, asthma, allergic alveolitis

Dermatologic

Common (1% to 10%): Rash (including urticaria)

Frequency not reported: Skin disease, alopecia, pruritus

Ocular

Frequency not reported: Photosensitivity, amblyopia, abnormal vision, visual field abnormality, diplopia

Genitourinary

A 30-year-old man developed erectile dysfunction after 2 months of treatment with anagrelide (the active ingredient contained in Agrylin) which disappeared 2 weeks after stopping the drug. A definitive cause could not be determined.

Frequency not reported: Dysuria, hematuria

Hypersensitivity

Very rare (less than 0.01%): A 60-year-old woman developed shortness of breath, palpitations, and chest pain after 1 week of treatment leading to respiratory failure and intubation by week 5. Patient recovered after treatment with methylprednisolone.

Frequency not reported: Severe hypersensitivity pneumonitis

The authors of the case report of severe hypersensitivity pneumonitis suggest that patients receiving anagrelide therapy, alone or in combination with hydroxyurea, may benefit from monitoring with serial chest X-rays, pulmonary function testing, and echocardiography to detect the development of cardiomyopathy or hypersensitivity pneumonitis.

Renal

Postmarketing reports: Tubulointerstitial nephritis.

Psychiatric

Frequency not reported: Depression

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Agrylin (www.drugs.com/mtm/agrylin.html).