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Adempas

Generic Name: riociguat (RYE oh SIG ue at)
Brand Names: Adempas
Adempas (riociguat) is used to treat pulmonary hypertension. Includes Adempas side effects, interactions and indications.
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Drug Information:
Adempas (riociguat) lowers blood pressure in your lungs, helping your heart pump blood more efficiently. Adempas is used to treat chronic thromboembolic pulmonary hypertension (CTEPH) in people who cannot be treated with surgery, or in people who have undergone surgery but still have symptoms. Riociguat can treat certain symptoms of CTEPH and can improve your ability to exercise. Adempas is also used to treat pulmonary arterial hypertension (PAH). Riociguat can improve your ability to exercise and help prevent PAH from getting worse. Learn more

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Adempas Side Effects

Note: This document contains side effect information about riociguat. Some of the dosage forms listed on this page may not apply to the brand name Adempas.

In Summary

Common side effects of Adempas include: dyspepsia, gastritis, and headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to riociguat: oral tablet

Warning

Oral route (Tablet)

Do not administer riociguat to a pregnant female because it may cause fetal harm. Females of reproductive potential: Exclude pregnancy before start of treatment, monthly during treatment, and 1 month after treatment discontinuation. To prevent pregnancy, females of reproductive potential must use effective forms of contraception during treatment and for one month after stopping treatment. For all females, riociguat is available only through a restricted program called the Adempas REMS Program.

Along with its needed effects, riociguat (the active ingredient contained in Adempas) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking riociguat:

More common

  • Confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • nosebleeds
  • unusual tiredness or weakness

Less common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or black, tarry stools
  • bruising or purple areas on the skin
  • coughing or spitting up blood
  • decreased alertness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • heavy non-menstrual vaginal bleeding
  • rapid weight gain
  • stomach pain or swelling
  • troubled breathing with exertion
  • vomiting of blood or material that looks like coffee grounds

Some side effects of riociguat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • headache
  • heartburn
  • indigestion
  • nausea
  • stuffy nose
  • vomiting

Less common

  • Difficulty having a bowel movement

For Healthcare Professionals

Applies to riociguat: oral tablet

General

The most frequently reported side effects were headache, dyspepsia/gastritis, dizziness, nausea, diarrhea, hypotension, vomiting, anemia, gastroesophageal reflux, and constipation.

Cardiovascular

Very common (10% or more): Peripheral edema (up to 17.3%), hypotension (up to 10%)

Common (1% to 10%): Palpitation, chest pain, chest discomfort

Nervous system

Very common (10% or more): Headache (up to 27%), dizziness (up to 20%)

Gastrointestinal

Very common (10% or more): Dyspepsia (up to 21%), gastritis (21%), nausea (up to 14.1%), diarrhea (up to 12%), vomiting (up to 10.2%)

Common (1% to 10%): Gastroesophageal reflux disease, constipation, gastroenteritis, gastrointestinal/abdominal pain, dysphagia, abdominal distention

Hematologic

Very common (10% or more): Hemoglobin decreased (24.1%), hematocrit decreased (13.3%)

Common (1% to 10%): Anemia

Respiratory

Very common (10% or more): Nasopharyngitis (11.8%)

Common (1% to 10%): Dyspnea, cough, nasal congestion, epistaxis, hemoptysis

Frequency not reported: Pulmonary hemorrhage

Musculoskeletal

Common (1% to 10%): Pain in extremity

Other

Common (1% to 10%): Fatigue

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Adempas (www.drugs.com/adempas.html).