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Note: This document contains side effect information about riociguat. Some of the dosage forms listed on this page may not apply to the brand name Adempas.
In SummaryCommon side effects of Adempas include: dyspepsia, gastritis, and headache. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to riociguat: oral tablet
Oral route (Tablet)
Do not administer riociguat to a pregnant female because it may cause fetal harm. Females of reproductive potential: Exclude pregnancy before start of treatment, monthly during treatment, and 1 month after treatment discontinuation. To prevent pregnancy, females of reproductive potential must use effective forms of contraception during treatment and for one month after stopping treatment. For all females, riociguat is available only through a restricted program called the Adempas REMS Program.
Along with its needed effects, riociguat (the active ingredient contained in Adempas) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking riociguat:
More common
Less common
Some side effects of riociguat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
For Healthcare Professionals
Applies to riociguat: oral tablet
GeneralThe most frequently reported side effects were headache, dyspepsia/gastritis, dizziness, nausea, diarrhea, hypotension, vomiting, anemia, gastroesophageal reflux, and constipation.
CardiovascularVery common (10% or more): Peripheral edema (up to 17.3%), hypotension (up to 10%)
Common (1% to 10%): Palpitation, chest pain, chest discomfort
Nervous systemVery common (10% or more): Headache (up to 27%), dizziness (up to 20%)
GastrointestinalVery common (10% or more): Dyspepsia (up to 21%), gastritis (21%), nausea (up to 14.1%), diarrhea (up to 12%), vomiting (up to 10.2%)
Common (1% to 10%): Gastroesophageal reflux disease, constipation, gastroenteritis, gastrointestinal/abdominal pain, dysphagia, abdominal distention
HematologicVery common (10% or more): Hemoglobin decreased (24.1%), hematocrit decreased (13.3%)
Common (1% to 10%): Anemia
RespiratoryVery common (10% or more): Nasopharyngitis (11.8%)
Common (1% to 10%): Dyspnea, cough, nasal congestion, epistaxis, hemoptysis
Frequency not reported: Pulmonary hemorrhage
MusculoskeletalCommon (1% to 10%): Pain in extremity
OtherCommon (1% to 10%): Fatigue
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Adempas (www.drugs.com/adempas.html).
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