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Note: This document contains side effect information about amphetamine / dextroamphetamine. Some of the dosage forms listed on this page may not apply to the brand name Adderall.
For the ConsumerApplies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet
Oral route (Tablet; Capsule, Extended Release)
Amphetamines have a high potential for abuse and administration for prolonged periods of time may lead to drug dependence. Misuse of amphetamines may cause sudden death and serious cardiovascular adverse reactions.
Oral route (Capsule, Extended Release)
CNS stimulants, including dextroamphetamine/amphetamine extended-release capsules, other amphetamine-containing products, and methylphenidate, have a high potential for abuse and dependence. Assess the risk of abuse prior to prescribing and monitor for signs of abuse and dependence while on therapy.
Along with its needed effects, amphetamine / dextroamphetamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking amphetamine / dextroamphetamine:
More common
Less common
Incidence not known
Some side effects of amphetamine / dextroamphetamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Incidence not known
For Healthcare Professionals
Applies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet
MetabolicVery common (10% or more): Appetite loss (up to 36%), weight loss (up to 10%)
Frequency not reported: Anorexia
GastrointestinalVery common (10% or more): Dry mouth (up to 35%), abdominal pain (up to 14%)
Common (1% to 10%): Nausea, vomiting, diarrhea, dyspepsia
Frequency not reported: Unpleasant taste, constipation, other GI disturbances
CardiovascularVery common (10% or more): Transient blood pressure elevations (up to 35%)
Common (1% to 10%): Tachycardia, palpitation
Frequency not reported: Cardiomyopathy, myocardial infarction, Raynaud's phenomenon
PsychiatricVery common (10% or more): Insomnia (up to 27%), nervousness (up to 13%)
Common (1% to 10%): Emotional lability, agitation, anxiety
Frequency not reported: Psychotic episodes, irritability, euphoria, dysphoria, restlessness, depression, aggression, anger, logorrhea, dermatillomania
Nervous systemVery common (10% or more): Headache (up to 26%)
Common (1% to 10%): Somnolence, dizziness, twitching, speech disorder (e.g., stuttering, excessive speech)
Frequency not reported: Overstimulation, paresthesia/formication, dyskinesia, tremor, exacerbation of motor/phonic tics and Tourette's syndrome
DermatologicCommon (1% to 10%): Photosensitivity reaction, sweating
Frequency not reported: Urticaria, rash, alopecia, serious skin rashes (e.g., Stevens-Johnson Syndrome, toxic epidermal necrolysis)
EndocrineCommon (1% to 10%): Decreased libido, dysmenorrhea, impotence
Frequency not reported: Frequent or prolonged erections
GenitourinaryCommon (1% to 10%): Urinary tract infection
OtherCommon (1% to 10%): Fever, infection, accidental injury, asthenia/fatigue, tooth disorder (e.g., teeth clenching, tooth infection)
Frequency not reported: Sudden death, bruxism
RespiratoryCommon (1% to 10%): Dyspnea
HypersensitivityFrequency not reported: Hypersensitivity reactions (e.g., angioedema, anaphylaxis)
OcularFrequency not reported: Blurred vision, mydriasis
MusculoskeletalPostmarketing reports: Rhabdomyolysis
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Adderall (www.drugs.com/adderall.html).
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