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Adcirca (tadalafil) relaxes muscles of the blood vessels and increases blood flow to particular areas of the body.
Adcirca is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.
Another brand of tadalafil is Cialis which used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate) in men. Do not take Adcirca while also taking Cialis, unless your doctor tells you to.
Taking Adcirca with certain other medicines can cause a sudden and serious decrease in blood pressure.
Do not take Adcirca if you also use riociguat, or a nitrate drug such as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, or recreational drugs such as "poppers."
Get medical help at once if you have nausea, chest pain, or dizziness during sex.
Stop using Adcirca and get emergency medical help if you have sudden vision loss.
You should not take Adcirca if you are allergic to tadalafil, or:
if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas).
Do not take Adcirca if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate, butyl nitrate or nitrite ("poppers"). Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.
Some tadalafil can remain in your bloodstream for 2 or more days after each dose you take (longer if you have liver or kidney disease). Avoid nitrate use during this time.
To make sure this medicine is safe for you, tell your doctor if you have ever had:
heart problems (chest pain, a heart rhythm disorder, heart failure);
a heart attack or stroke;
high or low blood pressure;
liver disease;
kidney disease (or if you are on dialysis);
retinitis pigmentosa (an inherited condition of the eye);
blindness in one or both eyes;
hearing problems;
blood circulation problems;
a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;
pulmonary veno-occlusive disease (PVOD);
a physical deformity of the penis (such as Peyronie's disease), or an erection lasting longer than 4 hours;
a stomach ulcer; or
health problems that make sexual activity unsafe.
A small number of people taking tadalafil have had sudden vision loss. Most of these people already had eye problems, or had diabetes or other health conditions that can affect blood vessels in the eyes. It is not clear whether tadalafil causes vision loss.
Do not start or stop taking Adcirca during pregnancy without your doctor's advice. Having pulmonary arterial hypertension (PAH) during pregnancy could harm may cause heart failure, stroke, or other medical problems in both mother and baby. Tell your doctor right away if you become pregnant.
You should not breastfeed while using tadalafil.
Cialis is not for use in women.
Adcirca is not approved for use by anyone younger than 18 years old.
Adcirca is usually taken only once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Adcirca can be taken with or without food. You may need to take two 20mg tablets for a full dose. Take both tablets one after the other. Do not split the dose
Do not take Cialis for erectile dysfunction if you are taking Adcirca for pulmonary arterial hypertension.
Do not change your Adcirca dose or stop taking this medicine without your doctor's advice.
Store at room temperature away from moisture and heat.
Usual Adult Dose for Pulmonary Hypertension:
40 mg orally once a day, with or without food.
Comment: Dividing the 40 mg dose over the course of the day is not recommended.
Since Cialis is used as needed, you are not likely to miss a dose.
If you miss a dose of Adcirca, take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid drinking alcohol. It may increase your risk of dizziness or fainting.
Grapefruit may interact with tadalafil and lead to unwanted side effects. Avoid the use of grapefruit products.
Get emergency medical help if you have signs of an allergic reaction to Adcirca: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using this medicine and call your doctor at once if you have:
heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
vision changes or sudden vision loss;
ringing in your ears or sudden hearing loss; or
an erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis).
Stop and get medical help at once if you have nausea, chest pain, or dizziness during sex. You could be having a life-threatening side effect.
Common Adcirca side effects may include:
headache;
flushing (warmth, redness, or tingly feeling);
nausea, upset stomach;
runny or stuffy nose; or
muscle pain, back pain, pain in your arms or legs.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Do not take Cialis with similar medications such as avanafil (Stendra), sildenafil (Viagra) or vardenafil (Levitra). Tell your doctor about all other medications you use for erectile dysfunction.
Tell your doctor about all your other medicines, especially:
medicines to treat erectile dysfunction or pulmonary arterial hypertension;
drugs to treat high blood pressure or a prostate disorder;
an antibiotic such as clarithromycin, erythromycin, rifampin, or telithromycin;
antifungal medicine such as ketoconazole or itraconazole;
medicine to treat HIV/AIDS, such as ritonavir and others; or
seizure medicine such as carbamazepine or phenytoin.
This list is not complete. Other drugs may interact with tadalafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Adcirca only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Adcirca (www.drugs.com/adcirca.html).
Note: This document contains side effect information about tadalafil. Some of the dosage forms listed on this page may not apply to the brand name Adcirca.
Common side effects of Adcirca include: back pain, dyspepsia, headache, limb pain, myalgia, nausea, and flushing. Other side effects include: nasal congestion. See below for a comprehensive list of adverse effects.
Applies to tadalafil: oral tablet
Along with its needed effects, tadalafil (the active ingredient contained in Adcirca) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking tadalafil:
Less common
Rare
Incidence not known
Some side effects of tadalafil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Rare
Applies to tadalafil: oral tablet
The most commonly reported adverse reactions were headache, nausea, dyspepsia, back pain, myalgia, flushing, nasopharyngitis, and pain in the extremity. These adverse reactions were dose dependent, transient, and generally mild or moderate.
Most patients that experienced side effects such as myocardial infarction, sudden cardiac death, stroke, palpitations, and tachycardia had preexisting cardiovascular risk factors. Many of these events were reported to occur during or shortly after sexual activity.
Very common (10% or more): Flushing (up to 14%)
Common (1% to 10%): Hypertension, hot flush
Uncommon (0.1% to 1%): Hypotension
Frequency not reported: Unstable angina pectoris, postural hypotension, ventricular arrhythmia
Postmarketing reports: Myocardial infarction, sudden cardiac death, stroke, chest pain, palpitations, and tachycardia, have been reported in temporal association with the use of this drug.
Very common (10% or more): Dyspepsia (up to 13%), nausea (up to 11%)
Common (1% to 10%): Diarrhea, gastroesophageal reflux disease, abdominal pain, gastroenteritis, constipation
Uncommon (0.1% to 1%): Vomiting
Frequency not reported: Dry mouth, dysphagia, esophagitis, gastritis, loose stools, nausea, upper abdominal pain, hemorrhoidal hemorrhage, rectal hemorrhage
Very common (10% or more): Myalgia (up to 14%), back pain (up to 12%), pain in extremity (up to 11%)
Common (1% to 10%): Pain in limb, musculoskeletal stiffness
Uncommon (0.1% to 1%): Arthralgia, muscle spasm
Frequency not reported: Neck pain
Very common (10% or more): Headache (up to 42%)
Common (1% to 10%): Dizziness (1%)
Rare (less than 0.1%): Transient global amnesia, transient ischemic attacks
Frequency not reported: Hypesthesia, somnolence, syncope, paraesthesia
Postmarketing reports: Migraine, seizure and seizure recurrence
Very common (10% or more): Nasopharyngitis (up to 13%), upper and lower respiratory tract infection (up to 13%)
Common (1% to 10%): Nasal congestion (including sinus congestion), cough, influenza, pulmonary hypertension, rhinitis
Uncommon (0.1% to 1%): Dyspnea, epistaxis
Frequency not reported: Pharyngitis
Common (1% to 10%): Urinary tract infection, menorrhagia (including uterine bleeding)
Uncommon (0.1% to 1%): Penile hemorrhage, hematospermia
Rare (less than 0.1%): Prolonged erections
Frequency not reported: Erection increased, spontaneous penile erection
Postmarketing reports: Priapism
In some of the cases, medical conditions and other factors were reported that may have also played a role in the otologic adverse events. In many cases, medical follow-up information was limited.
Common (1% to 10%): Peripheral edema, fatigue, edema
Uncommon (0.1% to 1%): Tinnitus
Rare (less than 0.1%): Facial edema
Frequency not reported: Vertigo, asthenia, pain
Postmarketing reports: Cases of sudden decrease or loss of hearing have been reported in temporal association with the use of this drug.
Uncommon (0.1% to 1%): Rash, urticaria, hyperhidrosis (sweating)
Rare (less than 0.1%): Angioedema
Frequency not reported: Pruritus
Postmarketing reports: Stevens-Johnson syndrome, exfoliative dermatitis
Most of the patients with NAION, but not all, had underlying anatomic or vascular risk factors, including but not necessarily limited to: Low cup to disc ratio ("crowded disc"), age over 50, diabetes, hypertension, coronary artery disease, hyperlipidemia, and smoking.
Uncommon (0.1% to 1%): Ocular hyperemia, eye pain, eyelid edema
Rare (less than 0.1%): Changes in color vision
Frequency not reported: Blurred vision, conjunctivitis (including conjunctival hyperemia), eye pain, lacrimation increased
Postmarketing reports: Visual field defect, retinal vein occlusion, and retinal artery occlusion. Non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including permanent loss of vision, has been reported in temporal association with the use of this drug.
Uncommon (0.1% to 1%): Hematuria
Frequency not reported: Renal impairment
Frequency not reported: Abnormal liver function tests, GGTP increased
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Adcirca (www.drugs.com/adcirca.html).
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