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Aczone Prescription
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Generic Name: dapsone topical (DAP sone TOP i kal)
Brand Names: Aczone
Aczone (dapsone) is a medicine used to help treat acne. Includes Aczone side effects, interactions and indications. Average Savings for dapsone (generic): 39.95%
Generic Name: dapsone topical (DAP sone TOP i kal)
Brand Names: Aczone
Aczone (dapsone) is a medicine used to help treat acne. Includes Aczone side effects, interactions and indications. Average Savings for dapsone (generic): 39.95%
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30 tablets of Aczone 40 mg
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Aczone Drug Information:

Aczone (Dapsone) is an anti-infective medication. Aczone is a topical gel used to help treat acne. The mechanism of action of in treating acne is not known. It is not for oral use. Use is contraindicated in persons with a hypersensitivity to Dapsone. Aczone gel may also be used for purposes not listed in this medication guide. Contact your doctor immediately if you develop a rash while using Aczone. In rare cases, Dapsone has been associated with serious, and sometimes fatal, skin reactions. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. Learn more

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Aczone Side Effects

Note: This document contains side effect information about dapsone topical. Some of the dosage forms listed on this page may not apply to the brand name Aczone.

For the Consumer

Applies to dapsone topical: topical gel/jelly

Along with its needed effects, dapsone topical (the active ingredient contained in Aczone) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dapsone topical:

Incidence not known

  • Bluish-colored lips, fingernails, or palms
  • dark urine
  • difficult breathing
  • dizziness or lightheadedness
  • fever
  • headache
  • pale skin
  • rapid heart rate
  • sore throat
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects of dapsone topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Dryness, redness, oiliness, or peeling at the application site

For Healthcare Professionals

Applies to dapsone topical: topical gel


Very common (10% or more): Local stinging/burning (up to 23.5%), application site reaction (not otherwise specified [NOS]; 18%), local dryness (up to 17.7%), application site dryness (up to 16%), application site erythema (up to 13%), application site oiliness/peeling (up to 13%), local scaling (up to 12.4%)

Common (1% to 10%): Local erythema, application site burning, application site pruritus

Uncommon (0.1% to 1%): Application site pain


Postmarketing reports: Rash (including erythematous rash, application site rash), facial swelling (including lip swelling, eye swelling)

Oral Dapsone:

-Frequency not reported: Skin reactions (toxic epidermal necrolysis, erythema multiforme, morbilliform and scarlatiniform reactions, bullous and exfoliative dermatitis, erythema nodosum, urticaria)


Postmarketing reports: Methemoglobinemia

Oral Dapsone:

-Frequency not reported: Agranulocytosis, hemolytic anemia

Nervous system

Common (1% to 10%): Headache NOS

Frequency not reported: Tonic clonic movements

Oral Dapsone:

-Frequency not reported: Peripheral neuropathy (motor loss and muscle weakness)


Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection NOS, sinusitis NOS, pharyngitis, cough, influenza

Frequency not reported: Severe pharyngitis


Common (1% to 10%): Pyrexia


Common (1% to 10%): Joint sprain


Uncommon: Depression

Rare (0.01% to 0.1%): Psychosis

Frequency not reported: Suicide attempt


Frequency not reported: Abdominal pain, severe vomiting, pancreatitis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Aczone (www.drugs.com/aczone.html).