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Accupril (quinapril) is an ACE inhibitor. ACE stands for angiotensin converting enzyme.
Accupril is used to treat high blood pressure (hypertension) and heart failure.
Accupril may also be used for purposes not listed in this medication guide.
Do not use Accupril if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.
You should not use quinaprilif you have ever had angioedema. Do not take Accupril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).
If you have diabetes, do not use Accupril together with any medication that contains aliskiren (such as Tekturna or Tekamlo).
You should not use Accupril if you are allergic to quinapril, or if:
you have a history of angioedema;
you recently took a heart medicine called sacubatril; or
if you are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, ramipril, or trandolapril.
Do not take Accupril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).
If you have diabetes, do not use Accupril together with any medication that contains aliskiren (such as Tekturna or Tekamlo).
You may also need to avoid taking quinapril with aliskiren if you have kidney disease.
To make sure Accupril is safe for you, tell your doctor if you have ever had:
kidney disease (or if you are on dialysis);
liver disease;
a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis;
heart disease or congestive heart failure (unless you are taking quinapril for this condition); or
if you are on a low-salt diet.
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Accupril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
Quinapril can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Take Accupril exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Your blood pressure will need to be checked often. Your kidney or liver function may also need to be tested.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking Accupril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.
If you need surgery, tell the surgeon ahead of time that you are using Accupril. You may need to stop using the medicine for a short time.
If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Store at room temperature away from moisture, heat, and light.
Usual Adult Dose for Hypertension:
Initial dose: 10 or 20 mg orally once a day in patients not on diuretics
Maintenance dose: 20 to 80 mg orally per day, administered as a single dose or in two equally divided doses
Use:
-Treatment of hypertension
Usual Adult Dose for Congestive Heart Failure:
Initial dose: 5 mg orally twice a day
Maintenance dose: 20 to 40 mg orally per day administered in two equally divided doses
Comments:
-This dose may improve symptoms of heart failure, but increases in exercise duration have generally required higher doses.
-If the initial dosage is well tolerated, patients should then be titrated at weekly intervals until an effective dose.
Use:
-Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis
Usual Geriatric Dose for Congestive Heart Failure:
10 mg orally once a day
Comments: Dose should be titrated the same way as for other adult patients.
Uses:
-Treatment of hypertension
-Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis
Usual Geriatric Dose for Hypertension:
10 mg orally once a day
Comments: Dose should be titrated the same way as for other adult patients.
Uses:
-Treatment of hypertension
-Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Do not use salt substitutes or potassium supplements while taking Accupril, unless your doctor has told you to.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of quinapril.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Get emergency medical help if you have signs of an allergic reaction to Accupril: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
fast or pounding heartbeats, fluttering in your chest;
little or no urination;
pain or burning when you urinate;
jaundice (yellowing of the skin or eyes);
numbness, tingling, or burning pain in your hands or feet;
fever, chills, cold or flu symptoms;
high potassium - nausea, slow or unusual heart rate, weakness, loss of movement; or
low sodium - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.
Common Accupril side effects may include:
headache;
cough; or
dizziness, tired feeling.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all your current medicines and any you start or stop using, especially:
lithium;
a diuretic or "water pill";
gold injections to treat arthritis; or
NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.
This list is not complete. Other drugs may interact with quinapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Accupril only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Accupril (www.drugs.com/accupril.html).
Note: This document contains side effect information about quinapril. Some of the dosage forms listed on this page may not apply to the brand name Accupril.
More frequent side effects include: cough. See below for a comprehensive list of adverse effects.
Applies to quinapril: oral tablet
Oral route (Tablet)
When pregnancy is detected, discontinue quinapril hydrochloride as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
Along with its needed effects, quinapril (the active ingredient contained in Accupril) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking quinapril:
Less common
Rare
Some side effects of quinapril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Applies to quinapril: oral tablet
The most commonly reported side effects were dizziness, increased serum creatinine, increased blood urea nitrogen, cough, dyspnea, nausea, vomiting, and diarrhea.
Uncommon (0.1% to 1%): Chest pain, hypotension, palpitations, vasodilation, tachycardia, heart failure, myocardial infarction, hypertensive crisis, angina pectoris, orthostatic hypotension, cardiac rhythm disturbances, cardiogenic shock
Common (1% to 10%): Increased serum creatinine, increased blood urea nitrogen
Uncommon (0.1% to 1%): Urinary tract infection, acute renal failure/dysfunction, worsening renal failure, proteinuria
Frequency not reported: Increases in blood urea nitrogen and serum creatinine
Uncommon (0.1% to 1%): Hyperkalemia, hyponatremia
Uncommon (0.1% to 1%): Hemolytic anemia, agranulocytosis, thrombocytopenia
Frequency not reported: Neutropenia, decreased hemoglobin, decreased hematocrit
Uncommon (0.1% to 1%): Angioedema of the head, neck, face, extremities, lips, tongue, glottis and/or larynx, intestines; anaphylactoid reactions
Uncommon (0.1% to 1%): Abnormal liver function tests, hepatitis
Rare (less than 0.1%): Hepatic failure (characterized by cholestatic jaundice with progression to fulminant hepatic necrosis and sometimes death)
Frequency not reported: Cholestatic icterus
Common (1% to 10%): Dizziness
Uncommon (0.1% to 1%): Headache, cerebrovascular accident/cerebral hemorrhage, somnolence, vertigo, syncope, nervousness, paresthesia, transient ischemic attacks, tinnitus
Rare (less than 0.1%): Balance disorder
Common (1% to 10%): Nausea, vomiting, diarrhea, dyspepsia, abdominal pain
Uncommon (0.1% to 1%): Flatulence, dry mouth or throat, constipation, gastrointestinal hemorrhage, pancreatitis
Rare (less than 0.1%): Glossitis
Very rare (less than 0.01%): Ileus
Common (1% to 10%): Cough, pharyngitis, dyspnea, rhinitis
Uncommon (0.1% to 1%): Eosinophilic pneumonitis, sinusitis, upper respiratory tract infection, bronchitis
Frequency not reported: Bronchospasm
Uncommon (0.1% to 1%): Myalgia, back pain, arthralgia
Uncommon (0.1% to 1%): Impotence
Uncommon (0.1% to 1%): Depression, insomnia, confusion
Common (1% to 10%): Fatigue, asthenia
Uncommon (0.1% to 1%): Fever, malaise, generalized/peripheral edema
Uncommon (0.1% to 1%): Viral infection
Uncommon (0.1% to 1%): Rash, alopecia, increased sweating, pemphigus, pruritus, exfoliative dermatitis, photosensitivity reaction, dermatopolymyositis
Rare (less than 0.1%): Urticaria, erythema multiforme, pemphigus
Very rare (less than 0.01%): Psoriasis-like efflorescence
Frequency not reported: Stevens Johnson syndrome, epidermal necrolysis
Uncommon (0.1% to 1): Amblyopia
Very rare (less than 0.01%): Blurred vision
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Accupril (www.drugs.com/accupril.html).
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