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How Much Does Accutane Cost?

If you’re one of the 50 million Americans who experiences acne annually, you’re no stranger to the embarrassment and discomfort the condition can cause. Although acne is often thought of as a teenage problem, acne can affect people at any stage of their lives and often continues well into a person’s 30s and 40s. An estimated 85 percent of adolescents and young adults between the ages of 12 and 24 experience some type of acne, and although many people experience only minor breakouts, for others, acne can become severe. Americans spend more than two billion dollars per year trying to treat their acne, but sometimes, only one option remains. When acne becomes moderate to severe and doesn’t respond to other treatments such as tetracycline  or absorica, a powerful dermatology drug called Accutane can be used to clear breakouts. Accutane was first introduced to the market in 1982, and this notoriously expensive drug is known to be extremely effective, but it comes with a long list of serious side effects. As generic forms of the drug entered the market, the cost of the medication has come down, so how much does Accutane cost today?

What Is Accutane?

Accutane was first approved for the treatment of acne by the U.S. Food and Drug Administration (FDA) in 1982. Known today under its generic name, isotretinoin, the brand name drug Accutane was discontinued by the manufacturers in 2009. Today, most people still refer to the drug by its brand name, however. Accutane is a derivative of vitamin A that is delivered at an extremely high dose. The medication belongs to a class of drugs known as retinoids, and is related to drugs like Retin-A. Accutane has been prescribed more than two million times and has been studied extensively due to the high risk of side effects associated with the medication.

What Is Accutane Used to Treat?

Accutane is used to treat moderate to severe forms of acne that have not been resolved by other types of treatment. Accutane use is most commonly tied to cystic or nodular acne, but it can also be used to treat other types that have not responded to treatment. Cystic acne is characterized by large, painful breakouts that form deep under the skin. It is commonly caused by clogged pores that trap bacteria, which is what causes normal pimples. With cystic acne, the infection becomes lodged deeper into the skin and creates a pus-filled cyst. Cystic acne can form on a person’s face, back, chest, upper arms, or shoulders, and it is more common in men. The condition can leave permanent scars that are very difficult to reduce later in life. 

How Does Accutane Work?

If you can believe it, Accutane actually works by altering DNA transcription in the body. When DNA transcription is altered, the size of the sebaceous, or oil-producing, glands in the body are reduced, and they produce less oil. Your skin cells change as well by becoming less “sticky,” which makes them less likely to form blackheads and whiteheads, which are the clogged pores that many of us think of when we think of acne. Additionally, the amount of bacteria in the sebaceous glands and on the skin is reduced. Because Accutane is a naturally occurring derivative of vitamin A, it actually already exists within all of our bodies naturally. By adding a larger dose of this derivative, the body’s DNA begins to change. 

How Much Does Accutane Cost?

Accutane has a reputation for being extremely expensive due to the monopoly it holds on the market for treating severe acne. The reality is that no other medication can treat severe acne as effectively. The brand name form of the drug has been off the market since 2009, and today, there are other manufacturers producing isotretinoin capsules. Isotretinoin is now sold under the brand names sotret, claravis, amnesteem, myorisan, and zenatene. The cost of Accutane can vary widely depending on the type of insurance you have, with co-pays ranging from 0 - 700 dollars or more. People with health insurance, including Medicare and Medicaid, will usually have some type of coverage for Accutane; however, the medication also requires monthly doctor’s visits due to the risks associated with taking the drug. These costs can combine to make Accutane extremely expensive. The cost of the medication also varies based on the dosage taken each day, which varies per person. Although Accutane is expensive, it normally only needs to be taken for four to six months before your skin is cleared. Although some people may need an additional course of treatment, either immediately following the first treatment or several years later, this is fairly uncommon. If the cost of Accutane is preventing you from taking the medication and you do not have health insurance, consider joining a pharmacy discount card program like USA Rx. USA Rx provides discounts on all FDA-approved medications, regardless of whether they are generic or name brand, and there are no registration costs or eligibility requirements. 

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What Side Effects and Risks Are Associated With Accutane Use?

Accutane is an extremely effective acne treatment for severe acne, but it is accompanied by many risks and side effects. The general categories of risks and side effects associated with Accutane are outlined below.

Reproductive System

Accutane causes severe birth defects that can cause miscarriage, death of the fetus, or premature birth. The effects of Accutane on unborn children are so severe that the FDA developed a program called iPLEDGE in order to prevent pregnancy in women taking Accutane. Under the iPLEDGE program, women of childbearing age must use at least two forms of birth control pills while taking Accutane, must undergo a monthly pregnancy blood test, and must take a monthly quiz about contraceptive methods in order to receive their prescription each month. The prescription must be filled within a certain number of days after the negative pregnancy test result is received. Birth defects caused by Accutane are known to include:

  • Hearing loss

  • Missing eyes

  • Small or missing thymus gland

  • Congenital heart defects

  • Small or missing ears

  • Small eyes

  • Cleft palate

  • Hydrocephalus, or buildup of fluid on the brain

  • Underdeveloped brain and small head (microcephaly)

Women should not get pregnant for at least four weeks after stopping Accutane.

Mental Health

Accutane is known to adversely affect mental health for some patients, including those who have never experienced mental health issues before. Depression, psychosis, and suicidal ideation and behaviors can increase in patients taking Accutane, so it is important that family and friends pay close attention for warning signs. Warning signs associated with declining mental health include:

  • Emotional outbursts

  • Visual or auditory hallucinations

  • Withdrawal

  • Suicidal thoughts

Skin and Hair

It is common for people taking Accutane to notice that their acne gets worse before it starts to get better. Side effects impacting the skin and hair associated with Accutane include:

  • Dry skin, sometimes severely dry

  • Chapped lips

  • Dry nasal passages, which can result in nose bleeds

  • Increased sun sensitivity

  • Faint yellowing of the skin

  • Skin becomes more fragile and peels

  • Thinning hair

Due to the increased sensitivity of your skin while taking Accutane, hair removal procedures or other harsh skin treatments should not be performed while taking Accutane or for six months after use.

Central Nervous System

Accutane also affects the central nervous system and commonly causes side effects like headaches and tiredness. Other side effects associated with the central nervous system include:

  • Dry eyes

  • Difficulty seeing in the dark

  • Ringing in the ears

  • Hearing loss, which can become permanent

  • Mood changes, including irritability or sadness

In rare cases, Accutane can cause increased pressure in the brain, which can be life-threatening. Symptoms of pressure in the brain include:

  • Blurred vision

  • Severe headache

  • Dizziness

  • Vomiting

  • Nausea

  • Seizures

  • Stroke

Digestive Tract

Accutane can cause uncomfortable side effects that impact digestion and excretion. Common side effects include:

  • Bleeding gums

  • Heartburn

  • Bowel pain

  • Nausea

  • Diarrhea

  • Joint pain 

  • Rectal bleeding

  • Reduced appetite

  • Stomach pain

  • Dark urine

  • Vomiting

  • Inflammatory bowel disease 

Most patients taking Accutane will undergo regular lab testing per their dermatologist to make sure that your organs are still functioning properly and that your cholesterol levels are stable. If you experience any of the side effects listed above, it may be a sign that your esophagus, liver, pancreas, or intestines are being damaged by the medication, so make sure to tell your doctor about any side effects that you are experiencing.

Other Side Effects

Because Accutane levels can build up in your bloodstream just like vitamin A, you may experience changes to your blood sugar and lipid levels. Your doctor will likely order lab work each month to make sure your levels are stable. White and red blood cell counts may also decrease while taking Accutane, resulting in weakness, feeling faint, or difficulty breathing. Some people experience pain in their bones, muscles, ligaments, and joints while taking the medication. Remember to seek medical advice if you aren't feeling well while taking the prescription drug. 

Sources:

https://www.aad.org/media/stats-numbers 

https://www.aocd.org/page/Accutane 

https://www.theatlantic.com/health/archive/2017/02/accutane-acne-drug-side-effects/516345/ 

https://www.webmd.com/skin-problems-and-treatments/cystic-acne#1 

https://www.verywellhealth.com/treatment-of-acne-with-isotretinoin-accutane-1068828 

https://www.ipledgeprogram.com/iPledgeUI/home.u

Published July 31st, 2020 by Bridget Reed
Fact Checked by Chris Riley

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